Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Kiran Sonaje"'
Publikováno v:
Pharmaceutics, Vol 13, Iss 1, p 88 (2021)
The targeted local delivery of anticancer therapeutics offers an alternative to systemic chemotherapy for oral cancers not amenable to surgical excision. However, epithelial barrier function can pose a challenge to their passive topical delivery. The
Externí odkaz:
https://doaj.org/article/1a110ffa01b64f2ca6abce42c897958e
Autor:
Fwu-Long Mi, Yong-Yi Wu, Yu-Hsin Lin, Kiran Sonaje, Yi-Cheng Ho, Chiung-Tong Chen, Jyuhn-Huarng Juang, Hsing-Wen Sung
Publikováno v:
Bioconjugate Chemistry. 33:747-747
Publikováno v:
Expert Opinion on Drug Delivery, Vol. 16, No 6 (2019) pp. 667-674
Background: The aim was to investigate cutaneous delivery and biodistribution of the hedgehog pathway inhibitor, vismodegib (VSD), indicated for basal cell carcinoma (BCC), from polymeric micelle formulations under infinite/finite dose conditions. Me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5db3465c9878795c129bc9617e45919e
Publikováno v:
Molecular Pharmaceutics. 13:500-511
The efficacy of some dermatological therapies might be improved by the use of "high dose" intraepidermal drug reservoir systems that enable sustained and targeted local drug delivery, e.g., in the treatment of keloids and hypertrophic scars. Here, a
Autor:
Barnali Maiti, Fang-Yi Su, Kiran Sonaje, Hsing-Wen Sung, Tzu Chen Yen, Nilendu Panda, Yi Cheng Ho, Shiaw-Pyng Wey, Er-Tuan Chuang, Kun-Ju Lin
Publikováno v:
Biomaterials. 33:2801-2811
Complexing agents such as diethylene triamine pentaacetic acid (DTPA) are known to disrupt intestinal tight junctions and inhibit intestinal proteases by chelating divalent metal ions. This study attempts to incorporate these benefits of DTPA in func
Publikováno v:
Accounts of Chemical Research. 45:619-629
Despite advances in drug-delivery technologies, successful oral administration of protein drugs remains an elusive challenge. When protein drugs are administered orally, they can rapidly denature or degrade before they reach their targets. Such drugs
Publikováno v:
Nanomedicine. 6:1297-1300
1297 ISSN 1743-5889 10.2217/NNM.11.124 © 2011 Future Medicine Ltd Nanomedicine (2011) 6(8), 1297–1300 “Oral insulin has been an interesting and promising area of research for the treatment of diabetes; it has tremendous ability to revolutionize
Autor:
Jyuhn Huarng Juang, Chia Wei Hsu, Ho Ngoc Nguyen, Hsing-Wen Sung, Er-Tuan Chuang, Shiaw-Pyng Wey, Kiran Sonaje, Tzu Chen Yen, Yi Cheng Ho, Kun-Ju Lin
Publikováno v:
Biomaterials. 32:2673-2682
Exendin-4 is a potent insulinotropic agent in diabetes patients; however, its therapeutic utility is limited due to the frequent injections required. In this study, an orally available exendin-4 formulation, using an enteric-coated capsule containing
Autor:
Kiran Sonaje, Jiun-Jie Wang, Kun-Ju Lin, Fwu Long Mi, Chiung-Tong Chen, Hsing-Wen Sung, Jyuhn Huarng Juang
Publikováno v:
Advanced Functional Materials. 20:3695-3700
The oral route is considered to be the most convenient and comfortable means of drug administration for patients. Nevertheless, oral administration of hydrophilic macromolecules such as peptide/protein drugs is encountered with many diffi culties. To