Zobrazeno 1 - 10 of 15 pro vyhledávání: '"Kiran S. Nadella"'
1
Data from Targeted Deletion of Prkar1a Reveals a Role for Protein Kinase A in Mesenchymal-to-Epithelial Transition
Autor: Lawrence S. Kirschner, Gustavo Leone, Constantine A. Stratakis, Anthony Trimboli, Georgette N. Jones, Kiran S. Nadella
Dysregulation of protein kinase A (PKA) activity, caused by loss of function mutations in PRKAR1A, is known to induce tumor formation in the inherited tumor syndrome Carney complex (CNC) and is also associated with sporadic tumors of the thyroid and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ed2f6dac8da8c49580284e585f24842
https://doi.org/10.1158/0008-5472.c.6498420
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3
Insulin-like growth factor 2 (IGF2) expression in adrenocortical disease due to PRKAR1A mutations compared to other benign adrenal tumors
Autor: Kiran S. Nadella, Constantine A. Stratakis, Fabio R. Faucz, Madson Q. Almeida, Isaac Levy, Annabel Berthon
Publikováno v: Endocrine. 72:823-834
Insulin-like growth factor-II (IGF2), a key regulator of cell growth and development, is tightly regulated in its expression by epigenetic control that maintains its monoallelic expression in most tissues. Biallelic expression of IGF2 resulting from
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dd64ed5a29082b692f8556e8371dcd1c
https://doi.org/10.1007/s12020-020-02583-z
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4
c-KIT oncogene expression in PRKAR1A-mutant adrenal cortex
Autor: Fabio R. Faucz, Constantine A. Stratakis, Kiran S. Nadella
Publikováno v: Endocr Relat Cancer
Protein kinase A (PKA) regulatory subunit type 1A (PRKAR1A) defects lead to primary pigmented nodular adrenocortical disease (PPNAD). The KIT protooncogene (c-KIT) is not known to be expressed in the normal adrenal cortex (AC). In this study, we inve
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0efe3fa923fb96bf44cb3f1f4042473
https://europepmc.org/articles/PMC7484269/
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5
Insulin-like growth factor 2 (IGF2) expression in adrenocortical disease due to PRKAR1A mutations compared to other benign adrenal tumors
Autor: Kiran S, Nadella, Annabel, Berthon, Madson Q, Almeida, Isaac, Levy, Fabio R, Faucz, Constantine A, Stratakis
Publikováno v: Endocrine. 72(3)
Insulin-like growth factor-II (IGF2), a key regulator of cell growth and development, is tightly regulated in its expression by epigenetic control that maintains its monoallelic expression in most tissues. Biallelic expression of IGF2 resulting from
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b488628bd2d3963172185b068c63d1c0
https://pubmed.ncbi.nlm.nih.gov/33420948
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6
Targeted Deletion of Prkar1a Reveals a Role for Protein Kinase A in Mesenchymal-to-Epithelial Transition
Autor: Georgette N. Jones, Gustavo Leone, Lawrence S. Kirschner, Anthony J. Trimboli, Kiran S. Nadella, Constantine A. Stratakis
Publikováno v: Cancer Research. 68:2671-2677
Dysregulation of protein kinase A (PKA) activity, caused by loss of function mutations in PRKAR1A, is known to induce tumor formation in the inherited tumor syndrome Carney complex (CNC) and is also associated with sporadic tumors of the thyroid and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d758f0de1d3866b038de5d0a33fb95cb
https://doi.org/10.1158/0008-5472.can-07-6002
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7
NOD/SCID mouse model of canine T-cell lymphoma with humoral hypercalcaemia of malignancy: cytokine gene expression profiling and in vivo bioluminescent imaging
Autor: Kiran S. Nadella, Douglas H. Thamm, Alper Yilmaz, Kathleen Boris-Lawrie, Thomas J. Rosol, Nandu K. Thudi, Murali V.P. Nadella, Elizabeth A. McNiel, William C. Kisseberth
Publikováno v: Veterinary and Comparative Oncology. 6:39-54
Lymphoma is a malignant neoplasm arising from B or T lymphocytes. In dogs, one-third of lymphomas are highly aggressive multicentric T-cell lymphomas that are often associated with humoral hypercalcaemia of malignancy (HHM). There are no cell lines o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3fa32b38e3eb732a730ca38ca0a88a1
https://doi.org/10.1111/j.1476-5829.2007.00139.x
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8
Inhibition of epidermal growth factor receptor signalling reduces hypercalcaemia induced by human lung squamous-cell carcinoma in athymic mice
Autor: John Foley, Ryan M. Gonterman, Davina A. Lewis, R. Laughner, P. F. Koltz, Ramiro E. Toribio, Raymond L. Konger, Thomas J. Rosol, Kiran S. Nadella, Gwendolen Lorch, Jennifer L. Gilmore
Publikováno v: British Journal of Cancer
The purpose of this study was to evaluate the role of the epidermal growth factor receptor (EGFR) in parathyroid hormone-related protein (PTHrP) expression and humoral hypercalcaemia of malignancy (HHM), using two different human squamous-cell carcin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::814805cdb4f337bdd12b0dab854a2652
http://europepmc.org/articles/PMC2360295
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9
Cyclic AMP and c-KIT signaling in familial testicular germ cell tumor predisposition
Autor: Maria Nesterova, Ethan Bornstein, Paraskevi Xekouki, Madson Q. Almeida, Martha Quezado, Evgenia Gourgari, Kiran S. Nadella, Mark H. Greene, Christian P. Kratz, Rodrigo Bertollo de Alexandre, Monalisa F. Azevedo, Constantine A. Stratakis, Elaine F. Remmers, Fabio R. Faucz, Anelia Horvath
Publikováno v: The Journal of clinical endocrinology and metabolism. 98(8)
Background: Familial testicular germ cell tumors (FTGCTs) are hypothesized to result from the combined interaction of multiple low-penetrance genes. We reported inactivating germline mutations of the cAMP-binding phosphodiesterase 11A (PDE11A) as mod
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d1f4443a8a613f4fe4287ac598a7443
https://pubmed.ncbi.nlm.nih.gov/23771924
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10
Expression of parathyroid hormone-related protein during immortalization of human peripheral blood mononuclear cells by HTLV-1: Implications for transformation
Autor: Sherry T. Shu, Soledad Fernandez, Thomas J. Rosol, Murali V.P. Nadella, Michael Dale Lairmore, Wessel P. Dirksen, Nanda K. Thudi, Kiran S. Nadella, Patrick L. Green
Publikováno v: Retrovirology
Retrovirology, Vol 5, Iss 1, p 46 (2008)
Background Adult T-cell leukemia/lymphoma (ATLL) is initiated by infection with human T-lymphotropic virus type-1 (HTLV-1); however, additional host factors are also required for T-cell transformation and development of ATLL. The HTLV-1 Tax protein p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d99525252fb43399bc6b6cf67b943723
https://doi.org/10.1186/1742-4690-5-46
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