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Autor:
Paul N. Reynolds, Thomas Schöndorf, Isabell Herrmann, Daniel T. Rein, M. Breidenbach, T. Schmidt, David T. Curiel, Israel Vlodavsky, Yosef S. Haviv, Kiran N. Khan
Publikováno v:
Cancer Letters. 240:114-122
Gene therapy with adenoviral (Ad) vectors is a promising new approach in the treatment of cancer. Strategies to restrict adenoviral-mediated transgene expression are important to avoid gene transfer into normal cells. Heparanase (HPR) is overexpresse