Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Kiran L Sharma"'
Autor:
Ravikumar Jimmidi, Srinivas Chamakuri, Shuo Lu, Melek Nihan Ucisik, Peng-Jen Chen, Kurt M. Bohren, Seyed Arad Moghadasi, Leroy Versteeg, Christina Nnabuife, Jian-Yuan Li, Xuan Qin, Ying-Chu Chen, John C. Faver, Pranavanand Nyshadham, Kiran L. Sharma, Banumathi Sankaran, Allison Judge, Zhifeng Yu, Feng Li, Jeroen Pollet, Reuben S. Harris, Martin M. Matzuk, Timothy Palzkill, Damian W. Young
Publikováno v:
Communications Chemistry, Vol 6, Iss 1, Pp 1-10 (2023)
Abstract The development of SARS-CoV-2 main protease (Mpro) inhibitors for the treatment of COVID-19 has mostly benefitted from X-ray structures and preexisting knowledge of inhibitors; however, an efficient method to generate Mpro inhibitors, which
Externí odkaz:
https://doaj.org/article/aab44f4c21884a5ab19d7b954a87359d
Publikováno v:
Canadian Journal of Gastroenterology and Hepatology, Vol 2018 (2018)
Externí odkaz:
https://doaj.org/article/31c2c7180cab40448104e11baf8aa097
Autor:
Ram K. Modukuri, Zhifeng Yu, Zhi Tan, Hai Minh Ta, Melek Nihan Ucisik, Zhuang Jin, Justin L. Anglin, Kiran L. Sharma, Pranavanand Nyshadham, Feng Li, Kevin Riehle, John C. Faver, Kevin Duong, Sureshbabu Nagarajan, Nicholas Simmons, Stephen S. Palmer, Mingxing Teng, Damian W. Young, Joanna S. Yi, Choel Kim, Martin M. Matzuk
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(22)
BRDT, BRD2, BRD3, and BRD4 comprise the bromodomain and extraterminal (BET) subfamily which contain two similar tandem bromodomains (BD1 and BD2). Selective BD1 inhibition phenocopies effects of tandem BET BD inhibition both in cancer models and, as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79a851d4e692ff7c8340bbbd30abba30
https://pubmed.ncbi.nlm.nih.gov/35622893
https://pubmed.ncbi.nlm.nih.gov/35622893
Publikováno v:
World Journal of Clinical Oncology
The field of "Cancer Genomics and Epigenomes" has been widely investigated for their involvement in cancer to understand the basic processes of different malignancies. The aggregation of genetic and epigenetic alterations also displays a wide range o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf4c9620590d539a66c59b03a0b3151e
https://doi.org/10.5306/wjco.v11.i11.890
https://doi.org/10.5306/wjco.v11.i11.890
Publikováno v:
The Saudi Journal of Gastroenterology, Vol 17, Iss 5, Pp 301-306 (2011)
Background/Aim: Degradation of the basement membrane and extracellular matrix by matrix metalloproteinases (MMPs) is believed to be an essential step in the complicated process of hematogenous metastasis. Matrix metalloproteinase-7 (MMP-7) is a small
Externí odkaz:
https://doaj.org/article/eb63d91555844d6eb7f52566d494f5b9
Autor:
Srinivas, Chamakuri, Shuo, Lu, Melek Nihan, Ucisik, Kurt M, Bohren, Ying-Chu, Chen, Huang-Chi, Du, John C, Faver, Ravikumar, Jimmidi, Feng, Li, Jian-Yuan, Li, Pranavanand, Nyshadham, Stephen S, Palmer, Jeroen, Pollet, Xuan, Qin, Shannon E, Ronca, Banumathi, Sankaran, Kiran L, Sharma, Zhi, Tan, Leroy, Versteeg, Zhifeng, Yu, Martin M, Matzuk, Timothy, Palzkill, Damian W, Young
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance SARS-CoV-2 has had a crippling impact on human life globally. Vaccine development has been used as a first-line strategy for COVID-19 prevention and mitigation; however, small-molecule drugs are still vitally needed to extend treatment o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::15cb54546b7f4431aeba52ef806a07ae
https://pubmed.ncbi.nlm.nih.gov/34426525
https://pubmed.ncbi.nlm.nih.gov/34426525
Autor:
Ravikumar Jimmidi, Kurt M. Bohren, Jeroen Pollet, Xuan Qin, Shannon E. Ronca, Timothy Palzkill, Shuo Lu, Zhifeng Yu, Damian W. Young, Srinivas Chamakuri, Zhi Tan, Ying-Chu Chen, Melek N. Ucisik, Feng Li, John C. Faver, J. Li, Stephen Palmer, Kiran L. Sharma, Martin M. Matzuk, Banumathi Sankaran, Huang-Chi Du, Leroy Versteeg, Pranavanand Nyshadham
Publikováno v:
Proceedings of the National Academy of Sciences. 118
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has killed more than 4 million humans globally, but there is no bona fide Food and Drug Administration-approved drug-like molecule to impede the COVID-19 pandemic. The sluggish pace of trad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a995856c9d6262ef493039a76779d55a
https://doi.org/10.1073/pnas.2111172118
https://doi.org/10.1073/pnas.2111172118
Publikováno v:
Current Sexual Health Reports. 11:201-211
To summarize data on lengthening treatments from PubMed-indexed scientific publications. Several surgical techniques achieve penile lengthening when combined with penile prosthesis (PP) implantation, including the sliding, incision/excision and graft
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dbd7354c37420df51930e7ec6bd47a3a
https://doi.org/10.1007/s11930-019-00211-0
https://doi.org/10.1007/s11930-019-00211-0
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e90264 (2014)
BACKGROUND AND AIM: Defective apoptosis is a hallmark of cancer development and progression. Death receptors (DR4, FAS) and their ligands (TRAIL, FASL) are thought to mediate the major extrinsic apoptotic pathway in the cell. SNPs in these genes may
Externí odkaz:
https://doaj.org/article/aedcbf97060f4f058546edb65060935e
Autor:
Kiran L. Sharma, Pingzhao Hu, James R. Davie, Wayne Xu, Tasnim H. Beacon, Shuo Jia, Camila López, Ifeoluwa Adewumi
Publikováno v:
Gene. 800
Treatment of serum-starved quiescent human cells with fetal bovine serum (FBS), epidermal growth factor (EGF), or the phorbol ester (12-O-tetradecanoylphorbol-13-acetate, TPA) activates the RAS-MAPK pathway which initiates a transcriptional program w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4267d8cdd96d53af274d98a62eaf0c92
https://pubmed.ncbi.nlm.nih.gov/34274479
https://pubmed.ncbi.nlm.nih.gov/34274479