Zobrazeno 1 - 10
of 99
pro vyhledávání: '"Kiran Kumar Solingapuram Sai"'
Autor:
Simon Deycmar, Brendan J. Johnson, Karina Ray, George W. Schaaf, Declan Patrick Ryan, Cassandra Cullin, Brandy L. Dozier, Betsy Ferguson, Benjamin N. Bimber, John D. Olson, David L. Caudell, Christopher T. Whitlow, Kiran Kumar Solingapuram Sai, Emily C. Romero, Francois J. Villinger, Armando G. Burgos, Hannah C. Ainsworth, Lance D. Miller, Gregory A. Hawkins, Jeff W. Chou, Bruno Gomes, Michael Hettich, Maurizio Ceppi, Jehad Charo, J. Mark Cline
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-21 (2024)
Abstract Background Naturally occurring colorectal cancers (CRC) in rhesus macaques share many features with their human counterparts and are useful models for cancer immunotherapy; but mechanistic data are lacking regarding the comparative molecular
Externí odkaz:
https://doaj.org/article/30efa148afbb4e31af85e684a6b0f213
Autor:
Naresh Damuka, Miranda E. Orr, Avinash H. Bansode, Ivan Krizan, Mack Miller, Jillian Lee, Shannon L. Macauley, Christopher T. Whitlow, Akiva Mintz, Suzanne Craft, Kiran Kumar Solingapuram Sai
Publikováno v:
EJNMMI Research, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Background Microtubules (MTs) are critical for cell structure, function, and survival. MT instability may contribute to Alzheimer’s disease (AD) pathogenesis as evidenced by persistent negative regulation (phosphorylation) of the neuronal
Externí odkaz:
https://doaj.org/article/55965fc1ff5845699b0af3989855e83d
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
Externí odkaz:
https://doaj.org/article/18ed96838adb4719ad7bb947c20368b8
[18F]KS1, a novel ascorbate-based ligand images ROS in tumor models of rodents and nonhuman primates
Autor:
Naresh Damuka, Nagaraju Bashetti, Akiva Mintz, Avinash H. Bansode, Mack Miller, Ivan Krizan, Cristina Furdui, Bhuvanachandra Bhoopal, Krishna Kumar Gollapelli, JV Shanmukha Kumar, Gagan Deep, Greg Dugan, Mark Cline, Kiran Kumar Solingapuram Sai
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 156, Iss , Pp 113937- (2022)
Over production of reactive oxygen species (ROS) caused by altered redox regulation of signaling pathways is common in many types of cancers. While PET imaging is recognized as the standard tool for cancer imaging, there are no clinically-approved PE
Externí odkaz:
https://doaj.org/article/9037725abf044ab3a4b3c63fe778673b
Autor:
Avinash H. Bansode, Bhuvanachandra Bhoopal, Krishna Kumar Gollapelli, Naresh Damuka, Ivan Krizan, Mack Miller, Suzanne Craft, Akiva Mintz, Kiran Kumar Solingapuram Sai
Publikováno v:
Pharmaceuticals, Vol 16, Iss 4, p 495 (2023)
Impairment and/or destabilization of neuronal microtubules (MTs) resulting from hyper-phosphorylation of the tau proteins is implicated in many pathologies, including Alzheimer’s disease (AD), Parkinson’s disease and other neurological disorders.
Externí odkaz:
https://doaj.org/article/8dad077cc62f4e1189a1a046efddcb2a
Autor:
Kiran Kumar Solingapuram Sai, Xiaofei Chen, Zhe Li, Caigang Zhu, Kirtikar Shukla, Tom E. Forshaw, Hanzhi Wu, Stephen A. Vance, Buddhika Liyana Pathirannahel, Megan Madonna, Mark W. Dewhirst, Allen W. Tsang, Leslie B. Poole, Nimmi Ramanujam, S. Bruce King, Cristina M. Furdui
Publikováno v:
Redox Biology, Vol 49, Iss , Pp 102218- (2022)
Redox metabolism plays essential functions in the pathology of cancer and many other diseases. While several radiotracers for imaging redox metabolism have been developed, there are no reports of radiotracers for in vivo imaging of protein oxidation.
Externí odkaz:
https://doaj.org/article/ecc67a86ed1c4c4e904350c15f9f92cd
Autor:
Naresh Damuka, Thomas J. Martin, Avinash H. Bansode, Ivan Krizan, Conner W. Martin, Mack Miller, Christopher T. Whitlow, Michael A. Nader, Kiran Kumar Solingapuram Sai
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
PurposeMicrotubules (MTs) are structural units made of α and β tubulin subunits in the cytoskeleton responsible for axonal transport, information processing, and signaling mechanisms—critical for healthy brain function. Chronic cocaine exposure a
Externí odkaz:
https://doaj.org/article/1953667dc0d34be8bd896d8904c0d0b6
Autor:
Brett M. Frye, Suzanne Craft, Thomas C. Register, Jeongchul Kim, Christopher T. Whitlow, Richard A. Barcus, Samuel N. Lockhart, Kiran Kumar Solingapuram Sai, Carol A. Shively
Publikováno v:
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 8, Iss 1, Pp n/a-n/a (2022)
Abstract Introduction Age‐related neuropathology associated with sporadic Alzheimer's disease (AD) often develops well before the onset of symptoms. Given AD's long preclinical period, translational models are needed to identify early signatures of
Externí odkaz:
https://doaj.org/article/b8b41adfa83d43e6a9a00983c099af51
Autor:
Kiran Kumar Solingapuram Sai, Nagaraju Bashetti, Xiaofei Chen, Skylar Norman, Justin W. Hines, Omsai Meka, J. V. Shanmukha Kumar, Sriram Devanathan, Gagan Deep, Cristina M. Furdui, Akiva Mintz
Publikováno v:
EJNMMI Research, Vol 9, Iss 1, Pp 1-10 (2019)
Abstract Background Reactive oxygen species (ROS)-induced oxidative stress damages many cellular components such as fatty acids, DNA, and proteins. This damage is implicated in many disease pathologies including cancer and neurodegenerative and cardi
Externí odkaz:
https://doaj.org/article/84e81fc151a54ca3bb8ab2e9bcd1e891
Autor:
Naresh Damuka, Paul W. Czoty, Ashley T. Davis, Michael A. Nader, Susan H. Nader, Suzanne Craft, Shannon L. Macauley, Lindsey K. Galbo, Phillip M. Epperly, Christopher T. Whitlow, April T. Davenport, Thomas J. Martin, James B. Daunais, Akiva Mintz, Kiran Kumar Solingapuram Sai
Publikováno v:
Molecules, Vol 25, Iss 10, p 2289 (2020)
Dysregulation of microtubules is commonly associated with several psychiatric and neurological disorders, including addiction and Alzheimer’s disease. Imaging of microtubules in vivo using positron emission tomography (PET) could provide valuable i
Externí odkaz:
https://doaj.org/article/9b5a4dabfabe4874b638821023220f1c