Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Kiran Kumar Naidu"'
Autor:
Kiran Kumar Naidu Guturi, Miyuki Bohgaki, Toshiyuki Bohgaki, Tharan Srikumar, Deborah Ng, Ramya Kumareswaran, Samah El Ghamrasni, Justin Jeon, Parasvi Patel, Mohamed Saad Eldin, Rob Bristow, Peter Cheung, Grant S. Stewart, Brian Raught, Anne Hakem, Razqallah Hakem
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
The E3 ligase RNF168 is essential for the signalling of DNA double strand break and its mutations are associated with the RIDDLE syndrome. Here the authors identify TOP2a as substrate for RNF168 and USP10; providing a link between the RNF168/USP10 ax
Externí odkaz:
https://doaj.org/article/d5a212c08e97474892af87b85618826a
Akademický článek
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Autor:
Anne Hakem, Parasvi S. Patel, Jonathan St-Germain, Marie-jo Halaby, Razqallah Hakem, Francesca Mateo, Daniel R. Barnes, Jonathan Beesley, Haithem Barbour, Karim Mekhail, Miquel Angel Pujana, El Bachir Affar, Cheryl H. Arrowsmith, Brian Raught, Samah El Ghamrasni, Arash Algouneh, Kiran Kumar Naidu Guturi, Otto Sanchez, Brandon Ho, Georgia Chenevix-Trench, Shili Duan, Antonis C. Antoniou, Zahra Khan, Karan J. Abraham, Hal K. Berman, Grant W. Brown, Luis Palomero
Publikováno v:
J Clin Invest
Germline mutations in BRCA1 and BRCA2 (BRCA1/2) genes considerably increase breast and ovarian cancer risk. Given that tumors with these mutations have elevated genomic instability, they exhibit relative vulnerability to certain chemotherapies and ta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8fe09874518ecab3f221c045d16ccb1
https://www.repository.cam.ac.uk/handle/1810/317678
https://www.repository.cam.ac.uk/handle/1810/317678
Akademický článek
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Autor:
Ian D. Hickson, R Cardoso, Ying Liu, Otto Sanchez, Razqallah Hakem, Manoor Prakash Hande, Victoria A. Bjerregaard, Kiran Kumar Naidu Guturi, Shriram Venkatesan, Jeffrey T. Henderson, Li Li, Anne Hakem, S El Ghamrasni
Publikováno v:
Oncogene. 35:4836-4845
Rad54 and Mus81 mammalian proteins physically interact and are important for the homologous recombination DNA repair pathway; however, their functional interactions in vivo are poorly defined. Here, we show that combinatorial loss of Rad54 and Mus81
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d286648b3399497fe3499b216414a525
https://doi.org/10.1038/onc.2016.16
https://doi.org/10.1038/onc.2016.16
Autor:
Otto Sanchez, Luis Palomero, El Bachir Affar, Brian Raught, Brandon Gautreau, Parasvi S. Patel, Chiara Pastrello, Miguel Angel Pujana, Razq Hakem, Hartland W. Jackson, Kiran Kumar Naidu Guturi, Max Kotlyar, Igor Jurisica, Li Li, Amine Saad, Haithem Barbour, Rama Khokha, Deborah Ng, Mayako Morii, Anne Hakem, Antonio Gomez, Francesca Mateo, Moulay A. Alaoui-Jamali
Publikováno v:
Dipòsit Digital de la UB
Universidad de Barcelona
J Clin Invest
Universidad de Barcelona
J Clin Invest
The E3 ubiquitin ligase RNF8 plays critical roles in maintaining genomic stability by promoting the repair of DNA double-strand breaks (DSBs) through ubiquitin signaling. Abnormal activation of Notch signaling and defective repair of DSBs promote bre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6984590b6f755f2a902aff712d5699ad
https://europepmc.org/articles/PMC6160000/
https://europepmc.org/articles/PMC6160000/
Akademický článek
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Autor:
Samah El Ghamrasni, Peter Cheung, Mohamed Saad Eldin, Toshiyuki Bohgaki, Robert G. Bristow, Tharan Srikumar, Anne Hakem, Deborah Ng, Parasvi S. Patel, Kiran Kumar Naidu Guturi, Razqallah Hakem, Miyuki Bohgaki, Brian Raught, Grant S. Stewart, Ramya Kumareswaran, Justin Jeon
Publikováno v:
Nature Communications
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Guturi, K K N, Bohgaki, M, Bohgaki, T, Srikumar, T, Ng, D, Kumareswaran, R, El Ghamrasni, S, Jeon, J, Patel, P, Eldin, M S, Bristow, R, Cheung, P, Stewart, G S, Raught, B, Hakem, A & Hakem, R 2016, ' RNF168 and USP10 regulate topoisomerase IIα function via opposing effects on its ubiquitylation ', Nature Communications, vol. 7, 12638 . https://doi.org/10.1038/ncomms12638
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Guturi, K K N, Bohgaki, M, Bohgaki, T, Srikumar, T, Ng, D, Kumareswaran, R, El Ghamrasni, S, Jeon, J, Patel, P, Eldin, M S, Bristow, R, Cheung, P, Stewart, G S, Raught, B, Hakem, A & Hakem, R 2016, ' RNF168 and USP10 regulate topoisomerase IIα function via opposing effects on its ubiquitylation ', Nature Communications, vol. 7, 12638 . https://doi.org/10.1038/ncomms12638
Topoisomerase IIα (TOP2α) is essential for chromosomal condensation and segregation, as well as genomic integrity. Here we report that RNF168, an E3 ligase mutated in the human RIDDLE syndrome, interacts with TOP2α and mediates its ubiquitylation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9aa3e9608b32d1a645f1518ef4075af4
https://pubmed.ncbi.nlm.nih.gov/27558965
https://pubmed.ncbi.nlm.nih.gov/27558965
Autor:
Christopher Heywood, Kiran Kumar Naidu
Publikováno v:
International Real Estate Review. 9:153-166
Business process outsourcing (BPO) is transforming Western companies’ corporate real estate (CRE) requirements. When business processes move to a developing country there are consequences for that country’s CRE practice. This paper considers the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2cbbac3cd3b15db64f02ccd9b2f464d9
https://doi.org/10.53383/100073
https://doi.org/10.53383/100073
Publikováno v:
International Real Estate Review. 9(1):153-166
Business process outsourcing (BPO) is transforming Western companies’ corporate real estate (CRE) requirements. When business processes move to a developing country there are consequences for that country’s CRE practice. This paper considers the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______645::853a13d6b9f98fcb2c3a4421c9ca0b1c