Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Kiran Kumar Kandukuri"'
Autor:
Kiran Kumar Kandukuri, Anil Shinde, Santoshkumar Pandey, Thrinath Reddy Bandyala, Abdul Rasheed Mohammed, Raghava Choudary Palacharla, Ramkumar Subramanian, Kumar Bojja, Sravanthi Manchineella, Pramod Kumar Achanta, Sangram Keshari Saraf, Venkat Jasti, Ramakrishna Nirogi, Rajesh Kumar Badange, Pradeep Jayarajan, Vijay Benade, Veena Reballi
Publikováno v:
Journal of Medicinal Chemistry. 62:1203-1217
A series of chemical optimizations guided by in vitro affinity at a histamine H3 receptor (H3R), physicochemical properties, and pharmacokinetics in rats resulted in identification of N-[4-(1-cyclobutyl-piperidin-4-yloxy)phenyl]-2-(morpholin-4-yl)ace
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a6a6e9590419cd78629224ee0312c10
https://doi.org/10.1021/acs.jmedchem.8b01280
https://doi.org/10.1021/acs.jmedchem.8b01280
Autor:
Ramakrishna, Nirogi, Anil, Shinde, Abdul Rasheed, Mohammed, Rajesh Kumar, Badange, Veena, Reballi, Thrinath Reddy, Bandyala, Sangram Keshari, Saraf, Kumar, Bojja, Sravanthi, Manchineella, Pramod Kumar, Achanta, Kiran Kumar, Kandukuri, Ramkumar, Subramanian, Vijay, Benade, Raghava Choudary, Palacharla, Pradeep, Jayarajan, Santoshkumar, Pandey, Venkat, Jasti
Publikováno v:
Journal of medicinal chemistry. 62(3)
A series of chemical optimizations guided by in vitro affinity at a histamine H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d3bc504790aa828f322e741792955470
https://pubmed.ncbi.nlm.nih.gov/30629436
https://pubmed.ncbi.nlm.nih.gov/30629436
Publikováno v:
Journal of Chemical Sciences. 127:439-445
In continuation to our efforts to develop better treatment options for cognitive decline, we have been focussing on 5-HT6 receptor (5-HT6R) antagonists, which are known to be involved in improving cognitive function in numerous animal models. In this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4835744ffbb3ae34f5c5ea0affa26b3a
https://doi.org/10.1007/s12039-015-0800-7
https://doi.org/10.1007/s12039-015-0800-7
Autor:
Jagadishu Babu Konda, Ramakrishna Nirogi, Vishwottam Kandikere, Pradeep Jayarajan, P. K. Dubey, Ramasastry Kambhampati, Kiran Kumar Kandukuri, Shinde Anil Karbhari, Parandhama Gudla, Thrinath Reddy Bandyala
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:6980-6985
The design, synthesis and SAR of novel tetrahydrocarbazole derivatives having 5-HT6 receptor antagonist activity is presented. The racemic compound 15e was found to possess desirable pharmacokinetic properties, adequate brain penetration and activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::010dc6e53434dce59a7c43514c8355e0
https://doi.org/10.1016/j.bmcl.2012.06.002
https://doi.org/10.1016/j.bmcl.2012.06.002
Autor:
Ramakrishna V S, Nirogi, Jagadishu Babu, Konda, Ramasastry, Kambhampati, Anil, Shinde, Thrinath Reddy, Bandyala, Parandhama, Gudla, Kiran Kumar, Kandukuri, Pradeep, Jayarajan, Vishwottam, Kandikere, P K, Dubey
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(22)
The design, synthesis and SAR of novel tetrahydrocarbazole derivatives having 5-HT(6) receptor antagonist activity is presented. The racemic compound 15e was found to possess desirable pharmacokinetic properties, adequate brain penetration and activi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::66df685d26b5c17106e53c52be3bf83b
https://pubmed.ncbi.nlm.nih.gov/23036955
https://pubmed.ncbi.nlm.nih.gov/23036955