Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Kiran K. Nagothu"'
Autor:
Prasad Devarajan, Takeshi Sugaya, Eisei Noiri, I. Kundi, Catherine L. Dent, Page C. Moore, Didier Portilla, Kiran K. Nagothu
Publikováno v:
Kidney International. 73:465-472
Acute kidney injury (AKI) is a major complication of cardiac bypass surgery. We examined whether levels of liver fatty acid-binding protein (L-FABP) can be an early biomarker for ischemic injury by measuring this protein in the urine of 40 pediatric
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa532117b9aa99de66a9f6040e5c504c
https://doi.org/10.1038/sj.ki.5002721
https://doi.org/10.1038/sj.ki.5002721
Autor:
Eisei Noiri, Kiran K. Nagothu, Judit Megyesi, Kousuke Negishi, Didier Portilla, Shenyang Li, Takeshi Sugaya
Publikováno v:
Kidney International. 72(3):348-358
Previous studies from our laboratory showed that increased fatty acid oxidation by the kidney is cytoprotective during cisplatin (CP)-mediated nephrotoxicity. In this study, we determined the effects of CP and fibrates on peroxisome proliferation and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14550ade70e168d64d06687fc677756e
Autor:
Kiran K. Nagothu, Didier Portilla, Richard Steward, John R. J. Sorenson, William M. Willingham, Peter Abeta Iyere, Renu Bhatt, Sudhir V. Shah, Grant W. Wangila
Publikováno v:
Toxicology in Vitro. 20:1300-1312
Copper 2 II ( 3 , 5 -ditertiarybutylsalicylate ) 4 ( ethanol ) 4 , Cu 2 II ( 3 , 5 -DTBS ) 4 ( Eth ) 4 , was synthesized and characterized for evaluation as an anti-apoptotic superoxide dismutase (SOD)-mimetic in an in vitro 50 μM cis-diamminedichlo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9cb9c2e4ea6b646a065ecbfd392394ed
https://doi.org/10.1016/j.tiv.2006.04.002
https://doi.org/10.1016/j.tiv.2006.04.002
Autor:
Robert L. Safirstein, Brigitte Kaissling, Richard D. Beger, Kiran K. Nagothu, Judit Megyesi, Shenyang Li, Didier Portilla, Laura K. Schnackenberg
Publikováno v:
Kidney International. 69:2194-2204
We have shown that cisplatin inhibits fatty acid oxidation, and that fibrate treatment ameliorates renal function by preventing the inhibition of fatty acid oxidation and proximal tubule cell death. Urine samples of mice treated with single injection
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f65689407414932ef3eb20faf56eccb9
https://doi.org/10.1038/sj.ki.5000433
https://doi.org/10.1038/sj.ki.5000433
Publikováno v:
Kidney International. 68:2680-2693
Fibrate prevents cisplatin-induced proximal tubule cell death. Background In previous studies we have shown that cisplatin inhibits peroxisome proliferator-activated receptor-α (PPAR-α) activity and consequently fatty acid oxidation, and these even
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c53531b9500753f71b05dca16ea24141
https://doi.org/10.1111/j.1523-1755.2005.00739.x
https://doi.org/10.1111/j.1523-1755.2005.00739.x
Autor:
Eva M. Schmelz, Adhip P.N. Majumdar, Richard Jaszewski, Kiran K. Nagothu, Fazlul H. Sarkar, Omer Kucuk, James S. Hatfield, Jianhua Du, Edi Levi, Volkan Adsay
Publikováno v:
Digestive Diseases and Sciences. 48:856-864
Aging and gastrointestinal malignancies, including that of the stomach are associated with increased activation of EGF-receptor (EGFR). Although the intracellular events that regulate this process are poorly understood, we hypothesize that loss of ER
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f7409324210d080d9ff036c81ff0987b
https://doi.org/10.1023/a:1023078924686
https://doi.org/10.1023/a:1023078924686
Autor:
Lathika Moragoda, Raphaela Finkenauer, Richard Jaszewski, Jo Ann Naumoff, Ravi Dhar, Kiran K. Nagothu, Arun K. Rishi, Omer Kucuk, Murray N. Ehrinpreis, Martin Tobi, Adhip P.N. Majumdar
Publikováno v:
Cancer Detection and Prevention. 27:297-304
Loss of heterozygosity (LOH) and/or inactivation of tumor suppressor genes are implicated in the initiation and progression of many malignancies, including colorectal cancer. Although accumulating evidence suggests a chemopreventive role for folate i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebd634948ee9e03f1abd74809656c72b
https://doi.org/10.1016/s0361-090x(03)00100-4
https://doi.org/10.1016/s0361-090x(03)00100-4
Autor:
M Kruger, Kerrie Lynn Ellis, Adhip P.N. Majumdar, Fazlul H. Sarkar, N.V. Adsay, J Feng, Kiran K. Nagothu
Publikováno v:
Pancreas. 25:342-349
Introduction and Aims: Epidermal growth factor (EGF) and its receptor (EGFR) play crucial roles in cellular signaling in many malignancies, including pancreatic neoplasia. Attenuation of EGFR signaling has been considered novel strategy for the manag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::911ef5058fde4148b4a9188e38fee338
https://doi.org/10.1097/00006676-200211000-00004
https://doi.org/10.1097/00006676-200211000-00004
Autor:
Kiran K. Nagothu, Gunilla Olivecrona, Judit Megyesi, Didier Portilla, Srinivas Ayyadevara, Sumant S. Chugh, Brian Shank, Sander Kersten, Gouri Ranganathan, Neriman Gokden, Shenyang Li, Syed M. Ali
Publikováno v:
American Journal of Physiology : Renal Physiology 303 (2012) 3
American Journal of Physiology : Renal Physiology, 303(3), F437-F448
American Journal of Physiology : Renal Physiology, 303(3), F437-F448
Peroxisome proliferator-activated receptor-α (PPARα) activation attenuates cisplatin (CP)-mediated acute kidney injury by increasing fatty acid oxidation, but mechanisms leading to reduced renal triglyceride (TG) accumulation could also contribute.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f77037e17c4f6ec877ae4df90feff4e
https://research.wur.nl/en/publications/reduced-kidney-lipoprotein-lipase-and-renal-tubule-triglyceride-a
https://research.wur.nl/en/publications/reduced-kidney-lipoprotein-lipase-and-renal-tubule-triglyceride-a
Autor:
William S. Branham, Varsha G. Desai, Didier Portilla, Mark D. Crew, Shenyang Li, Judit Megyesi, Kiran K. Nagothu, Taewon Lee, Carrie L. Moland
Publikováno v:
Kidney international. 76(10)
Our previous studies suggest that peroxisome proliferator-activated receptor-alpha (PPARalpha) plays a critical role in regulating fatty acid beta-oxidation in kidney tissue and this directly correlated with preservation of kidney morphology and func
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6752e9f66d8f754513498e8b5ee4555
https://pubmed.ncbi.nlm.nih.gov/19876055
https://pubmed.ncbi.nlm.nih.gov/19876055