Výsledky vyhledávání - "Kiran Bharat, Lokhande"

Akademický článek

Elucidating B4GALNT1 as potential biomarker in hepatocellular carcinoma using machine learning models and mutational dynamics explored through MD simulation

Autor: Rohit Kumar Verma, Kiran Bharat Lokhande, Prashant Kumar Srivastava, Ashutosh Singh

Publikováno v: Informatics in Medicine Unlocked, Vol 48, Iss , Pp 101514- (2024)

Liver hepatocellular carcinoma (LIHC) is considered one of the primary contributors to cancer-related mortality on a global scale. The identification of new biomarkers is of utmost importance due to the fact that patients with LIHC are frequently det

Externí odkaz: https://doaj.org/article/b43d0aaac75148f4ba1a8a60d31c950b

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Akademický článek

Evaluation of immune evasion in SARS-CoV-2 Delta and Omicron variants

Autor: Armi M. Chaudhari, Madhvi Joshi, Dinesh Kumar, Amrutlal Patel, Kiran Bharat Lokhande, Anandi Krishnan, Katja Hanack, Slawomir Filipek, Dorian Liepmann, Venkatesan Renugopalakrishnan, Ramasamy Paulmurugan, Chaitanya Joshi

Publikováno v: Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 4501-4516 (2022)

Emerging SARS-CoV-2 variants with higher transmissibility and immune escape remain a persistent threat across the globe. This is evident from the recent outbreaks of the Delta (B.1.617.2) and Omicron variants. These variants have originated from diff

Externí odkaz: https://doaj.org/article/a34c1a6cb2df4f79933af63379748cee

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Akademický článek

4-Methylesculetin ameliorates LPS-induced depression-like behavior through the inhibition of NLRP3 inflammasome

Autor: Khushboo Choudhary, Surendra Rajit Prasad, Kiran Bharat Lokhande, Krishna Murti, Sanjiv Singh, Velayutham Ravichandiran, Nitesh Kumar

Publikováno v: Frontiers in Pharmacology, Vol 14 (2023)

The pathophysiology of depression is heavily dependent on inflammation. Evidence suggests that the etiology of depression is linked with NLRP3 inflammasome-induced inflammation. Therefore, blocking the activated NLRP3 inflammasome may be beneficial f

Externí odkaz: https://doaj.org/article/0ce32e2f49744ba5bf11aa0832b995de

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Akademický článek

Free Fatty Acids from Cow Urine DMSO Fraction Induce Cell Death in Breast Cancer Cells without Affecting Normal GMSCs

Autor: Ajay Kumar Raj, Vidhi Upadhyay, Kiran Bharat Lokhande, K. Venkateswara Swamy, Ramesh Ramchandra Bhonde, Sachin C. Sarode, Nilesh Kumar Sharma

Publikováno v: Biomedicines, Vol 11, Iss 3, p 889 (2023)

Objective: The objective of this study was to explore the biological relevance of free fatty acids derived from cow urine DMSO fraction (CUDF) by employing in vitro and in silico approaches. Background: Metabolic heterogeneity at the intra- and inter

Externí odkaz: https://doaj.org/article/a3be7ad8db3c4392a995da333283ea7d

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Exploring Potential Non-steroidal Aromatase Inhibitors for Therapeutic Application against Estrogen-dependent Breast Cancer

Autor: Shuchi Nagar, Khushboo Pandey, Kiran Bharat Lokhande, Achintya Saha, Arvind Goja, Kakumani Venkateswara Swamy

Publikováno v: Current Computer-Aided Drug Design. 19:243-257

Background: Breast cancer is one of the most commonly diagnosed cancer types among women worldwide. Cytochrome P450 aromatase (CYP19A1) is an enzyme in vertebrates that selectively catalyzes the biosynthesis of estrogens from androgenic precursors. R

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::530bc0ff2d529425c39b13256f26c782
https://doi.org/10.2174/1573409919666230112170025

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Akademický článek

Exploration of Phytoconstituents From and as Potential Therapeutics Against SARS-CoV-2 RdRp

Autor: Khushboo Pandey, Kiran Bharat Lokhande, K Venkateswara Swamy, Shuchi Nagar, Manjusha Dake

Publikováno v: Bioinformatics and Biology Insights, Vol 15 (2021)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) worldwide has increased the importance of computational tools to design a drug or vaccine in reduced time with minimum risk. Earlier studies have emphasized the important role of RNA-depend

Externí odkaz: https://doaj.org/article/f929c830511f4536b8d41428b4f49982

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Design, docking, synthesis, and in vitro evaluation of potent anti-tubercular agents targeting DNA Gyrase

Autor: Asha B. Thomas, Manjiri D. Bhosale, Kiran Bharat Lokhande, Kakumani VenkateswaraSwamy, Soumya Basu, Sohan S. Chitlange

Publikováno v: Letters in Drug Design & Discovery. 20

Background: Tuberculosis caused by Mycobacterium tuberculosis has been reported to infect about two-third of the global population and to continuously develop multidrug resistance. DNA gyrase, a type II topoisomerase, is a promising target of the qui

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e48aa8d4e831d0dc02c8785ca30090c5
https://doi.org/10.2174/1570180820666230523155640

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Predicted role of Acetyl-CoA synthetase and HAT p300 in extracellular lactate mediated lactylation in the tumor: In vitro and in silico models

Autor: Rushikesh Patel, Ajay Kumar, Kiran Bharat Lokhande, Mrudula Joshi, Kratika Khunteta, Jayanta K. pal, Prof. Nilesh Kumar Sharma

Background As per the Warburg effect, cancer cells are known to convert pyruvate into lactate. The accumulation of lactate is associated with metabolic and epigenetic reprogramming, which has newly been suggested to involve lactylation. However, the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b90b95df0165a6d97bcf3ff1469e0de8
https://doi.org/10.26434/chemrxiv-2023-dp5kt-v2

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