Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Kira V Gromova"'
Autor:
André T Lopes, Torben J Hausrat, Frank F Heisler, Kira V Gromova, Franco L Lombino, Timo Fischer, Laura Ruschkies, Petra Breiden, Edda Thies, Irm Hermans-Borgmeyer, Michaela Schweizer, Jürgen R Schwarz, Christian Lohr, Matthias Kneussel
Publikováno v:
PLoS Biology, Vol 18, Iss 8, p e3000820 (2020)
Mutations in the gene encoding the microtubule-severing protein spastin (spastic paraplegia 4 [SPG4]) cause hereditary spastic paraplegia (HSP), associated with neurodegeneration, spasticity, and motor impairment. Complicated forms (complicated HSP [
Externí odkaz:
https://doaj.org/article/fd94a10cc9314b0d9d95e7c1e309a73e
Autor:
Daniele Stajano, Franco L. Lombino, Michaela Schweizer, Markus Glatzel, Paul Saftig, Kira V. Gromova, Matthias Kneussel
Publikováno v:
Journal of Extracellular Biology, Vol 2, Iss 9, Pp n/a-n/a (2023)
Abstract Neurons in the central nervous system release extracellular vesicles (EVs) and exosomes in response to synaptic activity to regulate physiological processes at target neurons. The intercellular transfer of proteins, mRNAs, lipids or metaboli
Externí odkaz:
https://doaj.org/article/5b642984c66640b5b1251b30ddfd3d80
Autor:
Kira V. Gromova, Edda Thies, Philipp C. Janiesch, Felix P. Lützenkirchen, Yipeng Zhu, Daniele Stajano, Céline D. Dürst, Michaela Schweizer, Anja Konietzny, Marina Mikhaylova, Christine E. Gee, Matthias Kneussel
Publikováno v:
Cell Reports, Vol 42, Iss 7, Pp 112743- (2023)
Summary: Homeostatic synaptic plasticity adjusts the strength of synapses to restrain neuronal activity within a physiological range. Postsynaptic guanylate kinase-associated protein (GKAP) controls the bidirectional synaptic scaling of AMPA receptor
Externí odkaz:
https://doaj.org/article/b4ea89a9a8004deeb934439ce397a69b
Autor:
Mary Muhia, PingAn YuanXiang, Jan Sedlacik, Jürgen R. Schwarz, Frank F. Heisler, Kira V. Gromova, Edda Thies, Petra Breiden, Yvonne Pechmann, Michael R. Kreutz, Matthias Kneussel
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-18 (2022)
A murine muskelin knockout induces increased exploratory drive and alters cognition and functional connectivity. These effects correlate with actin-dependent changes in dendritic branching, spine structure, and AMPAR-mediated synaptic transmission.
Externí odkaz:
https://doaj.org/article/2a57e15d62354e63a3239b6cceda15bf
Autor:
Kira V. Gromova, Mary Muhia, Nicola Rothammer, Christine E. Gee, Edda Thies, Irina Schaefer, Sabrina Kress, Manfred W. Kilimann, Olga Shevchuk, Thomas G. Oertner, Matthias Kneussel
Publikováno v:
Cell Reports, Vol 23, Iss 9, Pp 2705-2717 (2018)
Autism spectrum disorders (ASDs) are associated with mutations affecting synaptic components, including GluN2B-NMDA receptors (NMDARs) and neurobeachin (NBEA). NBEA participates in biosynthetic pathways to regulate synapse receptor targeting, synapti
Externí odkaz:
https://doaj.org/article/ca348ec380c54b27b6fa8ba02855ace0
Autor:
Wolfgang Wagner, Kristina Lippmann, Frank F. Heisler, Kira V. Gromova, Franco L. Lombino, Mona K. Roesler, Yvonne Pechmann, Sönke Hornig, Michaela Schweizer, Simona Polo, Jürgen R. Schwarz, Jens Eilers, Matthias Kneussel
Publikováno v:
Cell Reports, Vol 28, Iss 1, Pp 11-20.e9 (2019)
Summary: Myosin VI is an actin-based cytoskeletal motor implicated in various steps of membrane trafficking. Here, we investigated whether this myosin is crucial for synaptic function and plasticity in neurons. We find that myosin VI localizes at cer
Externí odkaz:
https://doaj.org/article/afe916e1b356400f8e150af47c713128
Autor:
Mary Muhia, Edda Thies, Dorthe Labonté, Amy E. Ghiretti, Kira V. Gromova, Francesca Xompero, Corinna Lappe-Siefke, Irm Hermans-Borgmeyer, Dietmar Kuhl, Michaela Schweizer, Ora Ohana, Jürgen R. Schwarz, Erika L.F. Holzbaur, Matthias Kneussel
Publikováno v:
Cell Reports, Vol 15, Iss 5, Pp 968-977 (2016)
The kinesin KIF21B is implicated in several human neurological disorders, including delayed cognitive development, yet it remains unclear how KIF21B dysfunction may contribute to pathology. One limitation is that relatively little is known about KIF2
Externí odkaz:
https://doaj.org/article/fe8a1afb790842fab33b17605daed690
Autor:
Franco L. Lombino, Jürgen R. Schwarz, Yvonne Pechmann, Michaela Schweizer, Markus Glatzel, Christine E. Gee, Kira V. Gromova, Matthias Kneussel
Dynamic microtubules transiently polymerize into dendritic spines, however intracellular factors that regulate this process and their functional role at synapses are hardly understood. Using live imaging, electrophysiology, and glutamate uncaging, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dedb22389405d1511c2558f2ca8e6f77
https://doi.org/10.1101/2022.05.04.490623
https://doi.org/10.1101/2022.05.04.490623
Autor:
Kira V. Gromova, Edda Thies, Céline D. Dürst, Daniele Stajano, Michaela Schweizer, Marina Mikhaylova, Christine E. Gee, Matthias Kneussel
Homeostatic synaptic plasticity adjusts the strength of synapses to restrain neuronal activity within a physiological range. Postsynaptic GKAP controls the bidirectional synaptic scaling of AMPA receptors (AMPARs) however how chronic activity trigger
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fceaf787e6876dad89cf53db51772c8d
https://doi.org/10.1101/2022.05.04.490582
https://doi.org/10.1101/2022.05.04.490582
Autor:
Frank F. Heisler, Franco L. Lombino, Mona Katrin Roesler, Matthias Kneussel, Jens Eilers, Kristina Lippmann, Michaela Schweizer, Wolfgang Wagner, Yvonne Pechmann, Kira V. Gromova, Jürgen R. Schwarz, Simona Polo, Sönke Hornig
Publikováno v:
Cell Reports, Vol 28, Iss 1, Pp 11-20.e9 (2019)
Summary: Myosin VI is an actin-based cytoskeletal motor implicated in various steps of membrane trafficking. Here, we investigated whether this myosin is crucial for synaptic function and plasticity in neurons. We find that myosin VI localizes at cer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23f1b5a0250b91629baa3a6441f4d5c6
http://www.sciencedirect.com/science/article/pii/S2211124719307636
http://www.sciencedirect.com/science/article/pii/S2211124719307636