Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Kira Sarup-Lytzen"'
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
The declining performance of scale-up bioreactor cultures is commonly attributed to phenotypic and physical heterogeneities. Here, the authors reveal multiple recurring intra-pathway error modes that limit engineered E. coli mevalonic acid production
Externí odkaz:
https://doaj.org/article/4caa8177d5ef40bd92bbb5f435868dd7
Autor:
Kira Sarup-Lytzen, Marcia Søgaard Brinck, Felipe Senne de Oliveira Lino, Morten Otto Alexander Sommer, Mareike Bongers, Felipe Gonzalo Tueros Farfan
Publikováno v:
Sarup-Lytzen, K, Brinck, M S, Lino, F S D O, Sommer, M O A, Bongers, M & Farfan, F G T Jan. 20 2022, Engineered probiotic bacteria for prebiotic-responsive control of colonization, Patent No. WO2022013269 .
Technical University of Denmark Orbit
Technical University of Denmark Orbit
The invention provides a recombinant probiotic gram-negative bacterium engineered to grow on a rare carbohydrate as sole carbon source, and whose ability to colonize the mammalian gut is responsive to the supply of said carbohydrate. The invention fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::82e0d1439698f3a6fee76608a194fa75
https://orbit.dtu.dk/en/publications/39c98822-cbac-409f-83f6-1166eb34dac1
https://orbit.dtu.dk/en/publications/39c98822-cbac-409f-83f6-1166eb34dac1
Publikováno v:
Rugbjerg, P, Sarup-Lytzen, K, Nagy, M & Sommer, M O A 2018, ' Synthetic addiction extends the productive life time of engineered Escherichia coli populations ', Proceedings of the National Academy of Sciences of the United States of America . https://doi.org/10.1073/pnas.1718622115
Bio-production of chemicals is an important driver of the societal transition toward sustainability. However, fermentations with heavily engineered production organisms can be challenging to scale to industrial volumes. Such fermentations are subject
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c237f35513e82118c95c0a7330bf8c9
https://doi.org/10.1073/pnas.1718622115
https://doi.org/10.1073/pnas.1718622115
Autor:
Morten Otto Alexander Sommer, Kira Sarup-Lytzen, Peter Rugbjerg, Nils Myling-Petersen, Andreas Porse
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Rugbjerg, P, Myling-Petersen, N, Porse, A, Sarup-Lytzen, K & Sommer, M O A 2018, ' Diverse genetic error modes constrain large-scale bio-based production ', Nature Communications, vol. 9, 787 . https://doi.org/10.1038/s41467-018-03232-w
Nature Communications
Rugbjerg, P, Myling-Petersen, N, Porse, A, Sarup-Lytzen, K & Sommer, M O A 2018, ' Diverse genetic error modes constrain large-scale bio-based production ', Nature Communications, vol. 9, 787 . https://doi.org/10.1038/s41467-018-03232-w
Nature Communications
A transition toward sustainable bio-based chemical production is important for green growth. However, productivity and yield frequently decrease as large-scale microbial fermentation progresses, commonly ascribed to phenotypic variation. Yet, given t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::691192d590ae3bc754006cbf9e2722ef
https://doaj.org/article/4caa8177d5ef40bd92bbb5f435868dd7
https://doaj.org/article/4caa8177d5ef40bd92bbb5f435868dd7
Autor:
Morten Otto Alexander Sommer, Kira Sarup-Lytzen, Hans Jasper Genee, George M. Church, Harris H. Wang, Sriram Kosuri, Mads Bonde
Publikováno v:
ACS synthetic biology, vol 4, iss 1
ACS Synthetic Biology
ACS Synthetic Biology
Multiplex Automated Genome Engineering (MAGE) allows simultaneous mutagenesis of multiple target sites in bacterial genomes using short oligonucleotides. However, large-scale mutagenesis requires hundreds to thousands of unique oligos, which are cost
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::276315b3032abfa60d053295bf61df1d
https://doi.org/10.1021/sb5001565
https://doi.org/10.1021/sb5001565
Autor:
Morten Otto Alexander Sommer, Kira Sarup-Lytzen, Hans Jasper Genee, Peter Rugbjerg, Kristian Jensen
Publikováno v:
Rugbjerg, P, Genee, H J, Jensen, K, Sarup-Lytzen, K & Sommer, M O A 2016, ' Molecular Buffers Permit Sensitivity Tuning and Inversion of Riboswitch Signals ', A C S Synthetic Biology, vol. 5, no. 7, pp. 632-638 . https://doi.org/10.1021/acssynbio.5b00213
ACS Synthetic Biology
ACS Synthetic Biology
Predictable integration of foreign biological signals and parts remains a key challenge in the systematic engineering of synthetic cellular actuations, and general methods to improve signal transduction and sensitivity are needed. To address this pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82b9ec2f3f4b705342a4022a21981b57
https://orbit.dtu.dk/en/publications/3eaebfc3-025d-4b05-ab6b-dec56a834ea1
https://orbit.dtu.dk/en/publications/3eaebfc3-025d-4b05-ab6b-dec56a834ea1
Publikováno v:
Technical University of Denmark Orbit
Rugbjerg, P, Sarup-Lytzen, K & Sommer, M O A Apr. 06 2017, A system for improved production titers in fermentations, Patent No. WO2017055360 .
Rugbjerg, P, Sarup-Lytzen, K & Sommer, M O A Apr. 06 2017, A system for improved production titers in fermentations, Patent No. WO2017055360 .
The invention provides a genetically modified micro-organism for intracellular biosynthesis of a cellular metabolite, comprising a synthetic error correction system having a penalty gene, whose expression leads to arrested growth or cell death (e.g.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::0b02dc3862da3369987295b87155f769
https://orbit.dtu.dk/en/publications/9db80d82-a2ff-4df3-90b0-4006f2270d9c
https://orbit.dtu.dk/en/publications/9db80d82-a2ff-4df3-90b0-4006f2270d9c