Výsledky vyhledávání - "Kira Meyerovich"

SKAP2, a Candidate Gene for Type 1 Diabetes, Regulates β-Cell Apoptosis and Glycemic Control in Newly Diagnosed Patients

Autor: Kira Meyerovich, Caroline Frørup, Simranjeet Kaur, Alessandra K Cardozo, Lotte B. Nielsen, Joachim Størling, Michala Prause, Henrik B. Mortensen, Flemming Pociot, Tina Fløyel

Publikováno v: Diabetes
Diabetes (New York, N.Y.), 70 (2

The single nucleotide polymorphism rs7804356 located in the Src kinase-associated phosphoprotein 2 (SKAP2) gene is associated with type 1 diabetes (T1D), suggesting SKAP2 as a causal candidate gene. The objective of the study was to investigate if SK

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd6df5a8ff92b2bedf342d204cf3a140
https://doi.org/10.2337/db20-0092

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SKAP2, a candidate gene for type 1 diabetes, regulates β-cell apoptosis and glycaemic control in newly diagnosed patients

Autor: Joachim Størling, Alessandra K. Cardozo, Flemming Pociot, Lotte B. Nielsen, Henrik B. Mortensen, Caroline Frørup, Simranjeet Kaur, Michala C. Prause, Kira Meyerovich, Tina Fløyel, Ada Admin

The single nucleotide polymorphism rs7804356 located in the Src kinase-associated phosphoprotein 2 (SKAP2) gene is associated with type 1 diabetes (T1D) suggesting SKAP2 as a causal candidate gene. The objective of the study was to investigate if SKA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::606059188a87cc65a4b2e50d7dcbdd5d
https://doi.org/10.2337/figshare.13217447.v1

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A20 Inhibits β-Cell Apoptosis by Multiple Mechanisms and Predicts Residual β-Cell Function in Type 1 Diabetes

Autor: Diane Delaroche, E C Vanzela, Fernanda Ortis, Henrik B. Mortensen, Lotte B Nielsen, Alessandra K Cardozo, Joachim Størling, Geert van Loo, Leen Catrysse, Makiko Fukaya, Rudi Beyaert, Flemming Pociot, Marie Louise Max M.L. Andersen, Caroline Brorsson, Kira Meyerovich

Publikováno v: Molecular Endocrinology. 30:48-61

Activation of the transcription factor nuclear factor kappa B (NFkB) contributes to β-cell death in type 1 diabetes (T1D). Genome-wide association studies have identified the gene TNF-induced protein 3 (TNFAIP3), encoding for the zinc finger protein

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::debff7b766cdfe4ae3f3b9d6495bfcb8
https://doi.org/10.1210/me.2015-1176

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The non-canonical NF-κB pathway and its contribution to β-cell failure in diabetes

Autor: Kira Meyerovich, Alessandra K Cardozo, Fernanda Ortis

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

The prevalence of diabetes has reached 8.8% in worldwide population and is predicted to increase up to 10.4% by 2040. Thus, there is an urgent need for the development of means to treat or prevent this major disease. Due to its role in inflammatory r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::615f18e393d99f6938c8d2a4eb616eed
https://pubmed.ncbi.nlm.nih.gov/29728424

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Heterozygous inactivation of plasma membrane Ca2+-ATPase in mice increases glucose-induced insulin release and beta cell proliferation, mass and viability

Autor: Julien Papin, André Herchuelz, Kira Meyerovich, Francesco P Zummo, Nathalie Pachera, Jacques Rahier, Alessandra K Cardozo, Jan Mast

Publikováno v: Diabetologia. 58:2843-2850

Calcium plays an important role in the process of glucose-induced insulin release in pancreatic beta cells. These cells are equipped with a double system responsible for Ca2+ extrusion—the Na/Ca exchanger (NCX) and the plasma membrane Ca2+-ATPase (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbcd6ca1ede792ee044bfcb7ba969522
https://doi.org/10.1007/s00125-015-3745-y

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MCL-1 is a Key Anti-Apoptotic Protein in Human and Rodent Pancreatic Beta cells

Autor: Makiko Fukaya, Natalia Moretti Violato, Decio L. Eizirik, Violette Dirix, Alessandra K Cardozo, Lorella Marselli, Andreas Strasser, Nathalie Pachera, Kira Meyerovich, Piero Marchetti

Publikováno v: Diabetes (New York, N.Y.), 66 (9
Diabetes

Induction of endoplasmic reticulum stress and activation of the intrinsic apoptotic pathway is widely believed to contribute to β-cell death in type 1 diabetes (T1D). MCL-1 is an anti-apoptotic member of the BCL-2 protein family, whose depletion cau

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::814fca50070e5f39ca94c803ba7e0e8a
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/254360

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Endoplasmic reticulum stress and the unfolded protein response in pancreatic islet inflammation

Autor: Fernanda Ortis, Alessandra K Cardozo, Florent Allagnat, Kira Meyerovich

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Insulin-secreting pancreatic β-cells are extremely dependent on their endoplasmic reticulum (ER) to cope with the oscillatory requirement of secreted insulin to maintain normoglycemia. Insulin translation and folding rely greatly on the unfolded pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c05a74ec0bebd20f45d8efadac52efb5

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The non-canonical NF-κB pathway is induced by cytokines in pancreatic beta cells and contributes to cell death and proinflammatory responses in vitro

Autor: Letícia Ferreira Terra, Decio L. Eizirik, Makiko Fukaya, Kira Meyerovich, Fernanda Ortis, Alessandra K Cardozo

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Activation of the transcription factor nuclear factor (NF)-κB by proinflammatory cytokines plays an important role in beta cell demise in type 1 diabetes. Two main signalling pathways are known to activate NF-κB, namely the canonical and the non-ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94c337f131e9588c819c66903e92bce0
https://pubmed.ncbi.nlm.nih.gov/26634571

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