Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Kira L. Tomlinson"'
Staphylococcus aureus stimulates neutrophil itaconate production that suppresses the oxidative burst
Autor:
Kira L. Tomlinson, Sebastián A. Riquelme, Swikrity Upadhyay Baskota, Marija Drikic, Ian R. Monk, Timothy P. Stinear, Ian A. Lewis, Alice S. Prince
Publikováno v:
Cell Reports, Vol 42, Iss 2, Pp 112064- (2023)
Summary: Neutrophils are critical in the host defense against Staphylococcus aureus, a major human pathogen. However, even in the setting of a robust neutrophil response, S. aureus can evade immune clearance. Here, we demonstrate that S. aureus impai
Externí odkaz:
https://doaj.org/article/767b8e41e2d14568853587d3c6c14abe
Autor:
Kira L. Tomlinson, Tania Wong Fok Lung, Felix Dach, Medini K. Annavajhala, Stanislaw J. Gabryszewski, Ryan A. Groves, Marija Drikic, Nancy J. Francoeur, Shwetha H. Sridhar, Melissa L. Smith, Sara Khanal, Clemente J. Britto, Robert Sebra, Ian Lewis, Anne-Catrin Uhlemann, Barbara C. Kahl, Alice S. Prince, Sebastián A. Riquelme
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
The authors show that the pathogen Staphylococcus aureus induces a distinct airway immunometabolic response, dominated by release of itaconate. This metabolite, in turn, potentiates extracellular polysaccharide synthesis and biofilm formation in S. a
Externí odkaz:
https://doaj.org/article/31b0833e7deb4acab5af4327ac64931d
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Pseudomonas aeruginosa and Staphylococcus aureus are both opportunistic pathogens that are frequently associated with chronic lung infections. While bacterial virulence determinants are critical in initiating infection, the metabolic flexibility of t
Externí odkaz:
https://doaj.org/article/e9539ca598bb4a55a3d9dac02bd5e3ae
Publikováno v:
Microbial Cell, Vol 8, Iss 5, Pp 106-107 (2021)
Staphylococcus aureus is a prominent pathogen that can cause intractable lung infections in humans. S. aureus persists in the airway despite inflammation and immune cell recruitment by adapting to host-derived antimicrobial factors. A key component o
Externí odkaz:
https://doaj.org/article/aa7631c97fdc41388fdfc4377a52f91f
Publikováno v:
Microbial Cell, Vol 8, Iss 5, Pp 106-107 (2021)
Staphylococcus aureus is a prominent pathogen that can cause intractable lung infections in humans. S. aureus persists in the airway despite inflammation and immune cell recruitment by adapting to host-derived antimicrobial factors. A key component o
Autor:
Clemente J. Britto, Sebastián A. Riquelme, Ryan A. Groves, Felix Dach, Ian A. Lewis, Medini K. Annavajhala, Robert Sebra, Barbara C. Kahl, Kira L. Tomlinson, Tania Wong Fok Lung, Sara Khanal, Shwetha Hara Sridhar, Marija Drikic, Anne-Catrin Uhlemann, Nancy Francoeur, Stanislaw J. Gabryszewski, Alice Prince, Melissa Smith
Publikováno v:
Microbial Cell
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
Staphylococcus aureus is a prominent human pathogen that readily adapts to host immune defenses. Here, we show that, in contrast to Gram-negative pathogens, S. aureus induces a distinct airway immunometabolic response dominated by the release of the