Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Kira A. Spencer"'
Autor:
Julia C. Stokes, Rebecca L. Bornstein, Katerina James, Kyung Yeon Park, Kira A. Spencer, Katie Vo, John C. Snell, Brittany M. Johnson, Philip G. Morgan, Margaret M. Sedensky, Nathan A. Baertsch, Simon C. Johnson
Publikováno v:
JCI Insight, Vol 7, Iss 5 (2022)
Symmetric, progressive, necrotizing lesions in the brainstem are a defining feature of Leigh syndrome (LS). A mechanistic understanding of the pathogenesis of these lesions has been elusive. Here, we report that leukocyte proliferation is causally in
Externí odkaz:
https://doaj.org/article/aee55270c21c4af99e428af868af6b62
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 13 (2020)
Ion channels are expressed throughout nervous system development. The type and diversity of conductances and gating mechanisms vary at different developmental stages and with the progressive maturational status of neural cells. The variety of ion cha
Externí odkaz:
https://doaj.org/article/5a13d9872f734ca8a1aaccb5237cfa83
Autor:
Kira A Spencer, Christian B Woods, Hailey M Worstman, Simon C Johnson, Jan-Marino Ramirez, Philip G Morgan, Margaret M Sedensky
Publikováno v:
Anesthesiology.
Background. A variety of molecular targets for volatile anesthetics have been suggested including the anesthetic-sensitive K+ leak channel, TREK-1. Knockout of TREK-1 is reported to render mice resistant to volatile anesthetics, making TREK-1 channel
Autor:
Julia C. Stokes, Rebecca L. Bornstein, Katerina James, Kyung Yeon Park, Kira A. Spencer, Katie Vo, John C. Snell, Brittany M. Johnson, Philip G. Morgan, Margaret M. Sedensky, Nathan A. Baertsch, Simon C. Johnson
Publikováno v:
JCI insight. 7(5)
Symmetric, progressive, necrotizing lesions in the brainstem are a defining feature of Leigh syndrome (LS). A mechanistic understanding of the pathogenesis of these lesions has been elusive. Here, we report that leukocyte proliferation is causally in
Autor:
Philip G. Morgan, Hailey M. Worstman, Sangwook Jung, Margaret M. Sedensky, Christian B. Woods, Kira A Spencer, Jan-Marino Ramirez
Publikováno v:
Anesthesiology
Background Ndufs4 knockout (KO) mice are defective in mitochondrial complex I function and hypersensitive to inhibition of spinal cord–mediated response to noxious stimuli by volatile anesthetics. It was hypothesized that, compared to wild-type, sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b20a03c0ddbf49d2912c0865fdab67e0
https://europepmc.org/articles/PMC8119385/
https://europepmc.org/articles/PMC8119385/
Publikováno v:
Journal of Developmental Biology, Vol 4, Iss 4, p 35 (2016)
Sonic hedgehog (Shh) signaling occurs concurrently with the many processes that constitute nervous system development. Although Shh is mostly known for its proliferative and morphogenic action through its effects on neural stem cells and progenitors,
Externí odkaz:
https://doaj.org/article/80916e8a1b454cf399ce705f2a27db31
Publikováno v:
Frontiers in Molecular Neuroscience
Frontiers in Molecular Neuroscience, Vol 13 (2020)
Frontiers in Molecular Neuroscience, Vol 13 (2020)
Ion channels are expressed throughout nervous system development. The type and diversity of conductances and gating mechanisms vary at different developmental stages and with the progressive maturational status of neural cells. The variety of ion cha
Autor:
Patricio A. Castro, I. Swapna, Olesya Visina, Eduardo Bouth Sequerra, Sangwoo Shim, Andrew M. Hamilton, Olga A. Balashova, Michelle K. Tu, Jacqueline B. Levin, Kira A. Spencer, Yesser H. Belgacem, Laura N. Borodinsky
Publikováno v:
Developmental Neurobiology. 75:349-359
Nervous system development relies on the generation of neurons, their differentiation and establishment of synaptic connections. These events exhibit remarkable plasticity and are regulated by many developmental cues. Here, we review the mechanisms o
Autor:
Kira A. Spencer, Olesya Visina, Henry Genus, Laura N. Borodinsky, Sangwoo Shim, Yesser H. Belgacem
Publikováno v:
Current biology : CB
Current biology : CB, vol 29, iss 11
Current biology : CB, vol 29, iss 11
SUMMARY During vertebrate development, spinal neurons differentiate and connect to generate a system that performs sensorimotor functions critical for survival. Spontaneous Ca2+ activity regulates different aspects of spinal neuron differentiation. I
Autor:
Monica Moreno, Lori Orosco, Kira A. Spencer, Staci L. Cates, Eduardo Bouth Sequerra, Jordan Lang
The generation and specification of pyramidal neuron subpopulations during development relies on a complex network of transcription factors. The CB(1) cannabinoid receptor is the major molecular target of endocannabinoids and marijuana active compoun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e211a3889eb707412c1055c5782af70b
https://europepmc.org/articles/PMC6705065/
https://europepmc.org/articles/PMC6705065/