Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Kira A Markossian"'
Autor:
Vera A Borzova, Kira A Markossian, Natalia A Chebotareva, Sergey Yu Kleymenov, Nikolay B Poliansky, Konstantin O Muranov, Vita A Stein-Margolina, Vladimir V Shubin, Denis I Markov, Boris I Kurganov
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0153495 (2016)
Thermal aggregation of bovine serum albumin (BSA) has been studied using dynamic light scattering, asymmetric flow field-flow fractionation and analytical ultracentrifugation. The studies were carried out at fixed temperatures (60°C, 65°C, 70°C an
Externí odkaz:
https://doaj.org/article/19dc1920d9f840eeb9ddea4450d6791f
Autor:
Vera A Borzova, Kira A Markossian, Dmitriy A Kara, Natalia A Chebotareva, Valentina F Makeeva, Nikolay B Poliansky, Konstantin O Muranov, Boris I Kurganov
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e74367 (2013)
The methodology for quantification of the anti-aggregation activity of protein and chemical chaperones has been elaborated. The applicability of this methodology was demonstrated using a test-system based on dithiothreitol-induced aggregation of bovi
Externí odkaz:
https://doaj.org/article/e2921f52ed514102a507d05056f5a1f3
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Chemical chaperones including arginine and its derivatives are widely used by biochemists working on the design of agents, which are able to efficiently suppress protein aggregation. To elucidate the mechanisms of anti-aggregation activity o
Externí odkaz:
https://doaj.org/article/8b2b652c7b3648cfbc11615f6a194c30
Autor:
Vera A. Borzova, Natalia A. Chebotareva, Nikolai N. Sluchanko, Sergey Yu Kleymenov, Kira A. Markossian, Boris I. Kurganov
Publikováno v:
Biochimie. 195:27-38
Chemical chaperones are low-molecular compounds counteracting protein aggregation. Understanding of the mechanism of their effects is key to their potential use in biotechnology. The aggregation of bovine liver glutamate dehydrogenase (GDH) was studi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e86e0f4f06401337a73bb12836c6076
https://doi.org/10.1016/j.biochi.2022.01.004
https://doi.org/10.1016/j.biochi.2022.01.004
Autor:
Boris I. Kurganov, Kira A. Markossian, Dmitriy A. Kara, Vera A. Borzova, Sergey Yu. Kleymenov
Publikováno v:
International Journal of Biological Macromolecules. 104:889-899
When studying the anti-aggregation activity of chemical chaperones, a kinetic regime of the aggregation process for selected test systems should be established. To elucidate the mechanism of suppression of protein aggregation by polyamines (putrescin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0087fb70b40afabc37d69a2360704ffa
https://doi.org/10.1016/j.ijbiomac.2017.06.092
https://doi.org/10.1016/j.ijbiomac.2017.06.092
Publikováno v:
International Journal of Biological Macromolecules. 80:130-138
A search for agents, which are capable of effectively suppressing protein aggregation, and elaboration of the appropriate test systems, are among important problems of modern biochemistry and biotechnology. One such test system is based on dithiothre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::373b77595f6c0c214131be850f077052
https://doi.org/10.1016/j.ijbiomac.2015.06.040
https://doi.org/10.1016/j.ijbiomac.2015.06.040
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Chemical chaperones including arginine and its derivatives are widely used by biochemists working on the design of agents, which are able to efficiently suppress protein aggregation. To elucidate the mechanisms of anti-aggregation activity of chemica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fda0881dd6f1ae6255eaaf04e485c05
https://doi.org/10.1038/s41598-017-04409-x
https://doi.org/10.1038/s41598-017-04409-x
Publikováno v:
International Journal of Biological Macromolecules. 68:144-150
Lag period is an inherent characteristic of the kinetic curves registered for protein aggregation. The appearance of a lag period is connected with the nucleation stage and the stages of the formation of folding or unfolding intermediates prone to ag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d2f8b5f12ea30bbd28b00e0b8f20a9a
https://doi.org/10.1016/j.ijbiomac.2014.04.046
https://doi.org/10.1016/j.ijbiomac.2014.04.046
Autor:
Boris I. Kurganov, Natalia A. Chebotareva, Sergey Yu. Kleymenov, Valentina F. Makeeva, Nikolay B. Poliansky, Olga I. Maloletkina, Kira A. Markossian, R.A. Asryants, K. O. Muranov
Publikováno v:
Biophysical Chemistry. :11-20
An aggregation test system based on the aggregation of UV-irradiated glyceraldehyde-3-phosphate dehydrogenase (GAPDH) from rabbit skeletal muscle has been proposed. On the basis of the measurements of the enzyme activity and differential scanning cal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6e070622e895b1808fc7cb75ca11ec6
https://doi.org/10.1016/j.bpc.2012.02.001
https://doi.org/10.1016/j.bpc.2012.02.001
Autor:
Olga I. Maloletkina, Lyubov V. Belousova, Sergey Yu. Kleimenov, Victor N. Orlov, Kira A. Markossian, Valentina F. Makeeva, Boris I. Kurganov
Publikováno v:
Biophysical Chemistry. 148:121-130
Effect of 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CD) on thermal aggregation of creatine kinase from rabbit skeletal muscle (RMCK) at 48 degrees C has been studied using dynamic light scattering. An increase in the duration of the lag period on th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::01ea7678e24ac658810071f2342f4550
https://doi.org/10.1016/j.bpc.2010.03.005
https://doi.org/10.1016/j.bpc.2010.03.005