Perisynaptic astrocytes as a potential target for novel antidepressant drugs

Autor: Marcos E. Frizzo, Yukihiro Ohno

Publikováno v: Journal of Pharmacological Sciences, Vol 145, Iss 1, Pp 60-68 (2021)

Emerging evidence suggests that dysfunctions in glutamatergic signaling are associated with the pathophysiology of depression. Several molecules that act on glutamate binding sites, so-called glutamatergic modulators, are rapid-acting antidepressants

Externí odkaz: https://doaj.org/article/c982da03963a45abbf228a06373deed5

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Inhibition of Inwardly Rectifying Potassium (Kir) 4.1 Channels Facilitates Brain-Derived Neurotrophic Factor (BDNF) Expression in Astrocytes

Autor: Masato Kinboshi, Takahiro Mukai, Yuki Nagao, Yusuke Matsuba, Yoshimi Tsuji, Shiho Tanaka, Kentaro Tokudome, Saki Shimizu, Hidefumi Ito, Akio Ikeda, Atsushi Inanobe, Yoshihisa Kurachi, Seiji Inoue, Yukihiro Ohno

Publikováno v: Frontiers in Molecular Neuroscience, Vol 10 (2017)

Inwardly rectifying potassium (Kir) 4.1 channels in astrocytes regulate neuronal excitability by mediating spatial potassium buffering. Although dysfunction of astrocytic Kir4.1 channels is implicated in the development of epileptic seizures, the fun

Externí odkaz: https://doaj.org/article/26b74b2d78b2456f84e62102d0768ce6

Perisynaptic astrocytes as a potential target for novel antidepressant drugs

Autor: Yukihiro Ohno, Marcos Emilio dos Santos Frizzo

Publikováno v: Repositório Institucional da UFRGS
Universidade Federal do Rio Grande do Sul (UFRGS)
instacron:UFRGS
Journal of Pharmacological Sciences, Vol 145, Iss 1, Pp 60-68 (2021)

Emerging evidence suggests that dysfunctions in glutamatergic signaling are associated with the pathophysiology of depression. Several molecules that act on glutamate binding sites, so-called glutamatergic modulators, are rapid-acting antidepressants

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c50c682fbc2bebf1d52bf6dbe1935994
https://pubmed.ncbi.nlm.nih.gov/33357781

Down-Regulation of Astrocytic Kir4.1 Channels during the Audiogenic Epileptogenesis in Leucine-Rich Glioma-Inactivated 1 (Lgi1) Mutant Rats

Autor: Ryosuke Takahashi, Tomoji Mashimo, Akio Ikeda, Masato Kinboshi, Saki Shimizu, Tadao Serikawa, Yukihiro Ohno, Hidefumi Ito

Publikováno v: International Journal of Molecular Sciences
Volume 20
Issue 5
International Journal of Molecular Sciences, Vol 20, Iss 5, p 1013 (2019)

The dysfunction of astrocytic inwardly rectifying potassium (Kir) 4.1 channels, which mediate the spatial potassium-buffering function of astrocytes, is known to be involved in the development of epilepsy. Here, we analyzed the Kir4.1 expressional ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c958376670005b2845b12a419255c325