Employing splice-switching oligonucleotides and AAVrh74.U7 snRNA to target insulin receptor splicing and cancer hallmarks in osteosarcoma.

Autor: Khurshid S; Center for Childhood Cancer Research, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH 43215, USA., Venkataramany AS; Center for Childhood Cancer Research, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH 43215, USA.; Biomedical Sciences Graduate Program, The Ohio State University, Columbus, OH 43210, USA.; Medical Scientist Training Program, The Ohio State University, Columbus, OH 43210, USA., Montes M; Department of Chemical and Systems Biology, Stanford University, Stanford, CA 94305, USA., Kipp JF; Center for Childhood Cancer Research, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH 43215, USA., Roberts RD; Center for Childhood Cancer Research, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH 43215, USA.; Division of Hematology, Oncology and Blood and Marrow Transplant, Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH 43215, USA., Wein N; Center for Childhood Cancer Research, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH 43215, USA., Rigo F; Ionis Pharmaceuticals, Carlsbad, CA 92010, USA., Wang PY; Center for Childhood Cancer Research, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH 43215, USA., Cripe TP; Center for Childhood Cancer Research, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH 43215, USA.; Division of Hematology, Oncology and Blood and Marrow Transplant, Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH 43215, USA., Chandler DS; Center for Childhood Cancer Research, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH 43215, USA.; Molecular, Cellular and Developmental Biology Graduate Program and The Center for RNA Biology, The Ohio State University, Columbus, OH 43210, USA.

Publikováno v: Molecular therapy. Oncology [Mol Ther Oncol] 2024 Nov 23; Vol. 32 (4), pp. 200908. Date of Electronic Publication: 2024 Nov 23 (Print Publication: 2024).