Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Kip Nalley"'
Publikováno v:
Cell. 127:261-264
Transcriptional activators need to be modulated and eventually switched off after the initial event that triggers their activation. Here, we discuss how ubiquitination of activators and their proteasome-mediated turnover are crucial steps in this pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8d60cab65f8e2da83afa0e0e897668a
https://doi.org/10.1016/j.cell.2006.10.002
https://doi.org/10.1016/j.cell.2006.10.002
Publikováno v:
Nature. 442:1054-1057
Transactivator-promoter complexes are essential intermediates in the activation of eukaryotic gene expression. Recent studies of these complexes have shown that some are quite dynamic in living cells owing to rapid and reversible disruption of activa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ae7175ccc74c20d3d60e578ede982a4d
https://doi.org/10.1038/nature05067
https://doi.org/10.1038/nature05067
Autor:
Kevin J. Tomaselli, Julia Herrmann, Robert O. Sayers, Joe C. Wu, Lalitha Kodandapani, Kathy G. Jahangiri, Craig D. Fisher, David T. Winn, Edward D. Robinson, Steven P. Meduna, Robert J. Ternansky, Pauline Yeo, Karen L. Valentino, Jose-Luis Diaz, Vincent J. Kalish, Steven D. Linton, Kristen Sebring, Robert A. Armstrong, Joseph F. Krebs, Niel C. Hoglen, Alfred P. Spada, Brad P. Hirakawa, Ning Chen, Brett R. Ullman, Brett Weylan Ching, Cheng-zhi Zhang, Xu Bai, Xin Gu, Kip Nalley, Long-Shiuh Chen, Patricia L. Gladstone, Jeff McQuiston, Teresa Aja, Todd Groessl, Donald S. Karanewsky, Suzanne Weeks, Lawrence C. Fritz, Patricia C. Contreras
Publikováno v:
Journal of Medicinal Chemistry. 48:6779-6782
A series of oxamyl dipeptides were optimized for pan caspase inhibition, anti-apoptotic cellular activity and in vivo efficacy. This structure-activity relationship study focused on the P4 oxamides and warhead moieties. Primarily on the basis of in v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc05f6b9f812322c1ff557485178cfdb
https://doi.org/10.1021/jm050307e
https://doi.org/10.1021/jm050307e
Autor:
Robert Smidt, Silvio Roggo, Julia Herrmann, Edward D. Robinson, Kathy G. Jahangiri, Teresa Aja, Kip Nalley, Thomas L. Deckwerth, Giorgio Rovelli, Kevin J. Tomaselli, Joe C. Wu, Bastian Hengerer, Steven P. Meduna, André Sauter, Jose-Luis Diaz, Joerg Kallen, Albert Schmitz, Donald S. Karanewsky, Brett R. Ullman, Steven D. Linton, Christoph Wiessner, Robert J. Ternansky, Peter R. Allegrini, Robert O. Sayers
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:2685-2691
Structural modifications were made to a previously described acyl dipeptide caspase inhibitor, leading to the oxamyl dipeptide series. Subsequent SAR studies directed toward the warhead, P2, and P4 regions of this novel peptidomimetic are described h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fb680f6d4dacf778afb32ec56f318e3
https://doi.org/10.1016/j.bmcl.2003.12.106
https://doi.org/10.1016/j.bmcl.2003.12.106
Autor:
Edward D. Robinson, Silvio Roggo, Joe C. Wu, Robert J. Ternansky, Jose-Luis Diaz, Teresa Aja, Kevin J. Tomaselli, Steven P. Meduna, Vincent J. Kalish, Donald S. Karanewsky, Robert O. Sayers, Albert Schmitz, Brett R. Ullman, Julia Herrmann, Kip Nalley, Thomas L. Deckwerth
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:3623-3626
Various aryloxy methyl ketones of the 1-naphthyloxyacetyl-Val-Asp backbone have been prepared. A systematic study of their structure-activity relationship (SAR) related to caspases 1, 3, 6, and 8 is reported. Highly potent irreversible broad-spectrum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::681ec055be84e31c81b8947185e1442d
https://doi.org/10.1016/s0960-894x(03)00755-8
https://doi.org/10.1016/s0960-894x(03)00755-8
Autor:
Teresa Aja, André Sauter, Donald S. Karanewsky, Markus Rudin, Rachel May, Peter R. Allegrini, Bastian Hengerer, Robert O. Sayers, Christoph Wiessner, Steve Linton, Albert Schmitz, Giorgio Rovelli, Kevin J. Tomaselli, Patricia C. Contreras, Joe C. Wu, Silvio Roggo, Kip Nalley, Lisa M. Adams, Thomas L. Deckwerth
Publikováno v:
Drug Development Research. 52:579-586
Apoptotic cell death occurs in the injured and diseased central nervous system. It is mediated by a family of caspases, which are activated by the lethal stimulus and cleave multiple protein substrates that are critical for cell viability. Previous s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa9ad16436d7f28cc9622c6484c77710
https://doi.org/10.1002/ddr.1161
https://doi.org/10.1002/ddr.1161
Autor:
Natasha Milinovikj, Maher Youssif, Andre Goy, K. Stephen Suh, Elyssa Schecter, Fathi Elloumi, Kip Nalley, Steven Russell, Andrew L. Pecora, Sreeja Sarojini
Publikováno v:
Journal of Oncology, Vol 2013 (2013)
Journal of Oncology
Journal of Oncology
Personalized medicine promises patient-tailored treatments that enhance patient care and decrease overall treatment costs by focusing on genetics and “-omics” data obtained from patient biospecimens and records to guide therapy choices that gener
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad18abedda2b471bc6a6893c5e2cd44f
https://doaj.org/article/a26f7ef0166945ceaecf4603c041adb5
https://doaj.org/article/a26f7ef0166945ceaecf4603c041adb5
Autor:
Kip Nalley
Publikováno v:
Enzyme Inhibitors Series ISBN: 9781420045406
Design of Caspase Inhibitors as Potential Clinical Agents
Design of Caspase Inhibitors as Potential Clinical Agents
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::448182de44bf95cd6190b68a392d8fd2
https://doi.org/10.1201/9781420045413.ch4
https://doi.org/10.1201/9781420045413.ch4
Autor:
Kip Nalley, Anwarul Ferdous, Stephen Albert Johnston, Melissa A. O'Neal, Devanjan Sikder, Thomas Kodadek
Recent analysis of a Gal4 mutant (Gap71) carrying three point mutations (S22D, K23Q and K25F) in its DNA-binding domain (DBD), has demonstrated that it cannot occupy GAL promoters efficiently in cells and that it is not mono-ubiquitylated, suggesting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8074758c1d2b5941f7991105841dfb7a
https://europepmc.org/articles/PMC4451857/
https://europepmc.org/articles/PMC4451857/
Autor:
Kip Nalley, Devanjan Sikder, Thomas Kodadek, Thomas G. Gillette, Stephen Albert Johnston, Anwarul Ferdous
Publikováno v:
Genesdevelopment. 21(1)
Recent studies have shown that the intersection between transcription and proteins involved in the ubiquitin–proteasome pathway encompasses both proteolytic and nonproteolytic functions. Examples of the latter type include evidence that monoubiquit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71f7b893e4d3c93f40d162d7e0f284e6
https://pubmed.ncbi.nlm.nih.gov/17167105
https://pubmed.ncbi.nlm.nih.gov/17167105