Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Kip Hermann"'
Autor:
Junhui Hu, Shiruyeh Schokrpur, Maani Archang, Kip Hermann, Allison C. Sharrow, Prateek Khanna, Jesse Novak, Sabina Signoretti, Rupal S. Bhatt, Beatrice S. Knudsen, Hua Xu, Lily Wu
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 9, Iss , Pp 203-210 (2018)
The CRISPR-based technology has revolutionized genome editing in recent years. This technique allows for gene knockout and evaluation of function in cell lines in a manner that is far easier and more accessible than anything previously available. Unf
Externí odkaz:
https://doaj.org/article/dc3d596a55cd4d0499009cc95592f618
Autor:
Patrick C Lee, Brian Truong, Agustin Vega-Crespo, W Blake Gilmore, Kip Hermann, Stephanie AK Angarita, Jonathan K Tang, Katherine M Chang, Austin E Wininger, Alex K Lam, Benjamen E Schoenberg, Stephen D Cederbaum, April D Pyle, James A Byrne, Gerald S Lipshutz
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 5, Iss C (2016)
Urea cycle disorders are incurable enzymopathies that affect nitrogen metabolism and typically lead to hyperammonemia. Arginase deficiency results from a mutation in Arg1, the enzyme regulating the final step of ureagenesis and typically results in d
Externí odkaz:
https://doaj.org/article/1fdc6566631f4520874fb9e231323021
Autor:
Prateek Khanna, Hua Xu, Rupal S. Bhatt, Allison C. Sharrow, Beatrice S. Knudsen, Jesse Novak, Shiruyeh Schokrpur, Maani M. Archang, Sabina Signoretti, Lily Wu, Kip Hermann, Junhui Hu
Publikováno v:
Molecular Therapy. Methods & Clinical Development
Molecular Therapy: Methods & Clinical Development, Vol 9, Iss, Pp 203-210 (2018)
Molecular Therapy: Methods & Clinical Development, Vol 9, Iss, Pp 203-210 (2018)
The CRISPR-based technology has revolutionized genome editing in recent years. This technique allows for gene knockout and evaluation of function in cell lines in a manner that is far easier and more accessible than anything previously available. Unf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49d14e3a1adf18a53ad1d487ba08483c
http://europepmc.org/articles/PMC5948229
http://europepmc.org/articles/PMC5948229
Autor:
Dale L. Boger, Gabriella Sghia-Hughes, Christopher M. Glinkerman, Elizabeth Simpson, Guoli Shi, Raymond R. Carillo, Saritha S. D'Souza, Kip Hermann, Hans-Peter Kiem, Nina D. Timberlake, Scott A. Snyder, Lauren E Schefter, Jennifer E. Adair, Kevin G. Haworth, Byoung Y. Ryu, Brian P. Sorrentino, Olivia Garijo, Bruce E. Torbett, Igor I. Slukvin, Stosh Ozog, Alex A. Compton
Publikováno v:
Blood
Therapeutic gene delivery to hematopoietic stem cells (HSCs) holds great potential as a life-saving treatment of monogenic, oncologic, and infectious diseases. However, clinical gene therapy is severely limited by intrinsic HSC resistance to modifica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fe627ca95d25d774eed5e2965968dee
https://pubmed.ncbi.nlm.nih.gov/31416800
https://pubmed.ncbi.nlm.nih.gov/31416800
Autor:
April D. Pyle, Brian Truong, Kip Hermann, Katherine M Chang, Patrick C. Lee, Alex K. Lam, Agustin Vega-Crespo, Austin E. Wininger, Gerald S. Lipshutz, Stephanie A.K. Angarita, Jonathan Tang, Stephen D Cederbaum, Benjamen E. Schoenberg, W Blake Gilmore, James A. Byrne
Publikováno v:
Molecular therapy. Nucleic acids, vol 5, iss 11
Molecular Therapy. Nucleic Acids
Molecular Therapy: Nucleic Acids, Vol 5, Iss C (2016)
Molecular Therapy. Nucleic Acids
Molecular Therapy: Nucleic Acids, Vol 5, Iss C (2016)
Urea cycle disorders are incurable enzymopathies that affect nitrogen metabolism and typically lead to hyperammonemia. Arginase deficiency results from a mutation in Arg1, the enzyme regulating the final step of ureagenesis and typically results in d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b6083db74e54d09c95bd5123f6e94ab
https://escholarship.org/uc/item/1vn3q67d
https://escholarship.org/uc/item/1vn3q67d
Autor:
Peijun Liu, Serghei Mangul, Matteo Pellegrini, Shiruyeh Schokrpur, Wei Guan, Junhui Hu, Lucia C. Lin, Lily Wu, Kip Hermann, Hua Xu, Diana Moughon
Publikováno v:
Scientific reports, vol 6, iss 1
Scientific Reports
Scientific Reports
Metastatic renal cell carcinoma (mRCC) is nearly incurable and accounts for most of the mortality associated with RCC. Von Hippel Lindau (VHL) is a tumour suppressor that is lost in the majority of clear cell RCC (ccRCC) cases. Its role in regulating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dd6583f544447b9caa5a40b8c41e530
https://escholarship.org/uc/item/2xd6z6t3
https://escholarship.org/uc/item/2xd6z6t3
Autor:
Patrick C. Lee, Kip Hermann, Gerald S. Lipshutz, Jason P. Awe, Katherine M Chang, James A. Byrne, Agustin Vega-Crespo, Brian Truong, Lily Wu, Benjamen E. Schoenberg
Publikováno v:
Molecular Therapy. Methods & Clinical Development
Molecular Therapy: Methods & Clinical Development, Vol 3, Iss C (2016)
Molecular Therapy: Methods & Clinical Development, Vol 3, Iss C (2016)
Pluripotent stem cells offer great therapeutic promise for personalized treatment platforms for numerous injuries, disorders, and diseases. Octamer-binding transcription factor 4 (OCT4) is a key regulatory gene maintaining pluripotency and self-renew
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5c20bde1d9e122ea27165f572062951
https://escholarship.org/uc/item/5gk789kv
https://escholarship.org/uc/item/5gk789kv
Autor:
Ian McGowan, Takahiro Kimura, Kip Hermann, Hiroshi Matsumoto, Kazunori Haga, Izumi Ohno, Kei Hiraoka, Noriyuki Kasahara, Peter A. Anton
Publikováno v:
BMC Gastroenterology
BMC gastroenterology, vol 14, iss 1
BMC gastroenterology, vol 14, iss 1
Background Therapeutic gene transfer is currently being evaluated as a potential therapy for inflammatory bowel disease. This study investigates the safety and therapeutic benefit of a locally administered lentiviral vector encoding murine interleuki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5632b807a318aa456bf399437e10c299
https://pubmed.ncbi.nlm.nih.gov/24712338
https://pubmed.ncbi.nlm.nih.gov/24712338
Autor:
Agustin Vega-Crespo, Kip Hermann, Jonathan Tang, Katherine M Chang, Patrick C. Lee, James A. Byrne, Gerald S. Lipshutz, Brian Truong, William B. Gilmore, Stephanie Kingman
Publikováno v:
Molecular Therapy. 24:S139
Urea cycle disorders (UCDs) are incurable genetic diseases that affect the body's ability to produce urea, leading to hyperammonemia due to a deficiency in any one of six enzymes in the cycle. For arginase deficiency, a mutation in the ARG1 gene, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6f07dc3832cd7f72d84b65046620df7
https://doi.org/10.1016/s1525-0016(16)33156-2
https://doi.org/10.1016/s1525-0016(16)33156-2
Autor:
Anna S. Gukovskaya, Samuel W. French, Ilya Gukovsky, Nobuhiko Katunuma, Paul Webster, Stephen J. Pandol, Mark S. O’Konski, Ann H. Erickson, Fred S. Gorelick, Kip Hermann, Olga A. Mareninova
The pathogenic mechanisms underlying acute pancreatitis are not clear. Two key pathologic acinar cell responses of this disease are vacuole accumulation and trypsinogen activation. We show here that both result from defective autophagy, by comparing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53eaca8f163aaa8dc26ed57a62ccadec