Frequent CHD1 deletions in prostate cancers of African American men is associated with rapid disease progression

Autor: Miklos Diossy, Viktoria Tisza, Hua Li, Pranshu Sahgal, Jia Zhou, Zsofia Sztupinszki, Denise Young, Darryl Nousome, Claire Kuo, Jiji Jiang, Yongmei Chen, Reinhard Ebner, Isabell A. Sesterhenn, Joel T. Moncur, Gregory T. Chesnut, Gyorgy Petrovics, Gregory T. Klus, Gabor Valcz, Pier Vitale Nuzzo, Dezso Ribli, Judit Börcsök, Aurel Prosz, Marcin Krzystanek, Thomas Ried, David Szuts, Kinza Rizwan, Salma Kaochar, Shailja Pathania, Alan D. D’Andrea, Istvan Csabai, Shiv Srivastava, Matthew L. Freedman, Albert Dobi, Sandor Spisak, Zoltan Szallasi

Publikováno v: npj Precision Oncology, Vol 8, Iss 1, Pp 1-13 (2024)

Abstract We analyzed genomic data from the prostate cancer of African- and European American men to identify differences contributing to racial disparity of outcome. We also performed FISH-based studies of Chromodomain helicase DNA-binding protein 1

Externí odkaz: https://doaj.org/article/3508a45a6daf4e298c016ff52086528b

The Prostate Cancer Androgen Receptor Cistrome in African American Men Associates with Upregulation of Lipid Metabolism and Immune Response

Autor: Jacob E. Berchuck, Elio Adib, Sarah Abou Alaiwi, Amit K. Dash, Jin Na Shin, Dallin Lowder, Collin McColl, Patricia Castro, Ryan Carelli, Elisa Benedetti, Jenny Deng, Matthew Robertson, Sylvan C. Baca, Connor Bell, Heather M. McClure, Talal El Zarif, Matthew P. Davidsohn, Gitanjali Lakshminarayanan, Kinza Rizwan, Darlene G. Skapura, Sandra L. Grimm, Christel M. Davis, Erik A. Ehli, Kaitlin M. Kelleher, Ji-Heui Seo, Nicholas Mitsiades, Cristian Coarfa, Mark M. Pomerantz, Massimo Loda, Michael Ittmann, Matthew L. Freedman, Salma Kaochar

Publikováno v: Cancer Res

African-American (AA) men are more likely to be diagnosed with and die from prostate cancer than European American (EA) men. Despite the central role of the androgen receptor (AR) transcription factor in prostate cancer, little is known about the con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1e7edf3b5e1a7b2d430c4771839cb75
https://doi.org/10.1158/0008-5472.can-21-3552

Data from The Prostate Cancer Androgen Receptor Cistrome in African American Men Associates with Upregulation of Lipid Metabolism and Immune Response

Autor: Salma Kaochar, Matthew L. Freedman, Michael Ittmann, Massimo Loda, Mark M. Pomerantz, Cristian Coarfa, Nicholas Mitsiades, Ji-Heui Seo, Kaitlin M. Kelleher, Erik A. Ehli, Christel M. Davis, Sandra L. Grimm, Darlene G. Skapura, Kinza Rizwan, Gitanjali Lakshminarayanan, Matthew P. Davidsohn, Talal El Zarif, Heather M. McClure, Connor Bell, Sylvan C. Baca, Matthew Robertson, Jenny Deng, Elisa Benedetti, Ryan Carelli, Patricia Castro, Collin McColl, Dallin Lowder, Jin Na Shin, Amit K. Dash, Sarah Abou Alaiwi, Elio Adib, Jacob E. Berchuck

African-American (AA) men are more likely to be diagnosed with and die from prostate cancer than European American (EA) men. Despite the central role of the androgen receptor (AR) transcription factor in prostate cancer, little is known about the con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::caf3322a1e69596184f2c34e6efa39b0
https://doi.org/10.1158/0008-5472.c.6514160.v1

Abstract 1705: SPOP: An essential gene for normal and prostate tumor cells

Autor: Kinza Rizwan, Darlene Skapura, Cammy Mason, Cristian Coarfa, Nicholas Mitsiades, Damian Young, Salma Kaochar

Publikováno v: Cancer Research. 83:1705-1705

Background: Prostate cancer (PC) is the single most common and second-most lethal cancer in men, with over 268,000 estimated cases and over 34,500 estimated deaths in the US in 2022. The Speckle-Type POZ protein (SPOP) mutant subclass of PC accounts

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::12cce2cb0db1b267503ae38e7a7adb79
https://doi.org/10.1158/1538-7445.am2023-1705

Diagnostic and Prognostic Markers for Pancreatitis and Pancreatic Ductal Adenocarcinoma.

Autor: Kantheti, Havish S.^1,2,3 (AUTHOR) havish.kantheti@tamu.edu, Hale, Michael A.^1,2,4 (AUTHOR) michael.hale@utsouthwestern.edu, Pal Choudhuri, Shreoshi^1,5 (AUTHOR) huocong.huang@utsouthwestern.edu, Huang, Huocong⁵ (AUTHOR) luc.girard@utsouthwestern.edu, Wang, Xu-dong⁶ (AUTHOR) yy3213@cumc.columbia.edu, Zolghadri, Yalda^2,7 (AUTHOR) giulio.innamorati@univr.it, Innamorati, Giulio⁷ (AUTHOR), Manikonda, Sai Prasada Rao⁸ (AUTHOR), Reddy, Naviya² (AUTHOR), Reddy, Sarthak² (AUTHOR), Kollipara, Rahul K.⁴ (AUTHOR), Lumani, Valbona^1,2 (AUTHOR), Girard, Luc⁵ (AUTHOR) rolf.brekken@utsouthwestern.edu, Bezrukov, Yakov⁹ (AUTHOR) y.bezrukov@cogia.de, Demenkov, Pavel⁹ (AUTHOR), MacDonald, Raymond J.¹⁰ (AUTHOR), Brekken, Rolf A.^5,11 (AUTHOR), Yu, Yonghao⁶ (AUTHOR), Wilkie, Thomas M.^1,2 (AUTHOR) thomas.wilkie@utsouthwestern.edu

Publikováno v: International Journal of Molecular Sciences. Jun2024, Vol. 25 Issue 12, p6619. 17p.