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Pharmacokinetics and Safety of Ascending Single Doses of DZ-2640, a New Oral Carbapenem Antibiotic, Administered to Healthy Japanese Subjects

Autor: Yoichi Murakami, Kenichi Sato, Hideo Hakusui, Kinuyo Kato, Makoto Tanaka, Yasushi Ito, Keiji Kawamoto

Publikováno v: Antimicrobial Agents and Chemotherapy. 44:578-582

DZ-2640 is the ester-type oral carbapenem prodrug of an active parent compound, DU-6681. The pharmacokinetics and safety of DU-6681 were investigated in six studies after oral administration of a single dose of DZ-2640 to healthy male Japanese volunt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fce560bb1856cc618072eeded515c012
https://doi.org/10.1128/aac.44.3.578-582.2000

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Estimation of height for persons in pictures

Autor: Atsuki Higashiyama, Kinuyo Kato

Publikováno v: Perception & Psychophysics. 60:1318-1328

We report three experiments in which subjects estimated the height of persons seen in pictures. In Experiment 1, 50 realistic photographs were used as targets. The correlation between mean estimated height and actual height was .92, and target's sex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53cc0412c537f8e714491a7e21870b33
https://doi.org/10.3758/bf03207994

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Studies on the Pharmacokinetics of Perindopril Erbumine in Rats. (1): Plasma Level Profile, Distribution, Metabolism and Excretion after Single Oral Administration

Autor: Yoshio Esumi, Yuko Otsu, Minoru Nakaoka, Michiko Shiina, Takahiro Nogami, Wataru Suzuki, Hideo Hakusui, Yoshitaka Jin, Yoshiharu Katami, Kinuyo Kato

Publikováno v: Drug Metabolism and Pharmacokinetics. 9:235-246

Pharmacokinetic studies on plasm a level, tissue distribution, metabolism and excretion of perindopril erbumine, an ACE inhibitor, were performed in fasting male rats after single oral administration of 14C-perindopril erbumine (14C-DW-7950) at a dos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0fe17d4bc7b732ef6813252c9de4c1ea
https://doi.org/10.2133/dmpk.9.235

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Sensitive semi-microcolumn high-performance liquid chromatographic method for the determination of DU-6681, the active parent drug of a new oral carbapenem antibiotic, DZ-2640, in human plasma and urine using a column-switching system as sample clean-up procedure

Autor: Makoto Tanaka, Kinuyo Kato

Publikováno v: Journal of chromatography. B, Biomedical sciences and applications. 724(1)

DZ-2640 is a new oral carbapenem antibiotic having a dihydro-pyrroloimidazole ring as a side chain and a pivaloyloxymethyl (POM) ester prodrug of DU-6681, the active parent compound. A simple and sensitive column-switching semi-microcolumn high-perfo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e529906cf5fa7c6600b59240ee290207
https://pubmed.ncbi.nlm.nih.gov/10202959

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Simple and selective assay of 4-hydroxymephenytoin in human urine using solid-phase extraction and high-performance liquid chromatography with electrochemical detection and its preliminary application to phenotyping test

Autor: Kinuyo Kato, Sunao Kaneko, Koichi Otani, Makoto Tanaka, Kan Chiba, Kazunobu Sugawara, Hideo Hakusui, Takashi Ishizaki, Kenichi Sudo, Tadashi Ohkubo

Publikováno v: Journal of chromatography. B, Biomedical applications. 676(1)

A simple and selective HPLC method for the determination of 4-hydroxymephenytoin (4-OH-M) in human urine, using a controlled potential coulometric detector equipped with a dual working electrode cell of fully porous graphite, has been developed. Afte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a82731c68eb8f76d65bb1d545803d80b
https://pubmed.ncbi.nlm.nih.gov/8852048

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