Výsledky vyhledávání - "Kinuka Isshiki"

Cell-Free Synthesis of Human Endothelin Receptors and Its Application to Ribosome Display

Autor: Hiroki Nakai, Kinuka Isshiki, Masato Hattori, Hiromasa Maehira, Tatsumi Yamaguchi, Keiko Masuda, Yoshihiro Shimizu, Takayoshi Watanabe, Takahiro Hohsaka, Wataru Shihoya, Osamu Nureki, Yasuhiko Kato, Hajime Watanabe, Tomoaki Matsuura

Publikováno v: Analytical chemistry. 94(9)

Engineering G-protein-coupled receptors (GPCRs) for improved stability or altered function is of great interest, as GPCRs consist of the largest protein family, are involved in many important signaling pathways, and thus, are one of the major drug ta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7e8348b28aea78def4e575c63aa51ad
https://pubmed.ncbi.nlm.nih.gov/35188389

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Intracellular localization and binding partners of death associated protein kinase-related apoptosis-inducing protein kinase 1

Autor: Keizo Yuasa, Yuna Oue, Akihiko Tsuji, Sara Murakami, Kinuka Isshiki

Publikováno v: Biochemical and biophysical research communications. 496(4)

Death associated protein kinase (DAPK)-related apoptosis-inducing protein kinase (DRAK)-1 is a positive apoptosis regulator. However, the molecular mechanisms underlying the DRAK1-mediated apoptotic pathway remain unclear. In this study, we demonstra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc1629800ecfc88c021a8f2f222084d8
https://pubmed.ncbi.nlm.nih.gov/29397938

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Death-associated protein kinase 2 mediates nocodazole-induced apoptosis through interaction with tubulin

Autor: Shinya Matsuda, Taishi Hirase, Kinuka Isshiki, Kenji Miyamoto, Akihiko Tsuji, Keizo Yuasa

Publikováno v: Biochemical and Biophysical Research Communications. 468:113-118

Death-associated protein kinase 2 (DAPK2) is a positive regulator of apoptosis. Although we recently reported that 14-3-3 proteins inhibit DAPK2 activity and its subsequent apoptotic effects via binding to DAPK2, the molecular mechanisms underlying t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11a04db2c5b10bcd6b00cd403a825d4e
https://doi.org/10.1016/j.bbrc.2015.10.151

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Suppression of death-associated protein kinase 2 by interaction with 14-3-3 proteins

Autor: Reina Ota, Kinuka Isshiki, Akihiko Tsuji, Keizo Yuasa, Masahiro Inoue, Shinya Matsuda

Publikováno v: Biochemical and Biophysical Research Communications. 464:70-75

Death-associated protein kinase 2 (DAPK2), a Ca(2+)/calmodulin-regulated serine/threonine kinase, induces apoptosis. However, the signaling mechanisms involved in this process are unknown. Using a proteomic approach, we identified 14-3-3 proteins as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3e19f1dc89c9e517bbb68c4efa1ff6b
https://doi.org/10.1016/j.bbrc.2015.05.105

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PCTAIRE Kinase 3/Cyclin-dependent Kinase 18 Is Activated through Association with Cyclin A and/or Phosphorylation by Protein Kinase A

Autor: Kinuka Isshiki, Shinya Matsuda, Keizo Yuasa, Kenji Miyamoto, Kyohei Kominato, Akihiko Tsuji, Shizuyo Koide-Yoshida

Publikováno v: Journal of Biological Chemistry. 289:18387-18400

PCTAIRE kinase 3 (PCTK3)/cyclin-dependent kinase 18 (CDK18) is an uncharacterized member of the CDK family because its activator(s) remains unidentified. Here we describe the mechanisms of catalytic activation of PCTK3 by cyclin A2 and cAMP-dependent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8456eeff0796d5166a296309ab50c2cf
https://doi.org/10.1074/jbc.m113.542936

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Engineering of 1-antitrypsin variants with improved specificity for the proprotein convertase furin using site-directed random mutagenesis

Autor: Kinuka Isshiki, Koichiro Hada, Shinya Matsuda, Keizo Yuasa, Akihiko Tsuji

Publikováno v: Protein Engineering Design and Selection. 26:123-131

Furin, PACE4, PC5/6 and PC7 are members of the subtilisin-like proprotein convertase (SPC) family. Although these enzymes are known to play critical roles in various physiological and pathological events including cell differentiation, tumor growth,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0374ec41dd98508dcf73c8e95edc1c6e
https://doi.org/10.1093/protein/gzs091

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cGMP-dependent protein kinase I promotes cell apoptosis through hyperactivation of death-associated protein kinase 2

Autor: Shinya Matsuda, Akihiko Tsuji, Kinuka Isshiki, Keizo Yuasa

Publikováno v: Biochemical and Biophysical Research Communications. 422:280-284

cGMP-dependent protein kinase-I (cGK-I) induces apoptosis in various cancer cell lines. However, the signaling mechanisms involved remain unknown. Using protein microarray technology, we identified a novel cGK substrate, death-associated protein kina

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::062044aa6681707725f7fd7ab0a51100
https://doi.org/10.1016/j.bbrc.2012.04.148

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Akademický článek

PCTAIRE Kinase 3/Cyclin-dependent Kinase 18 Is Activated through Association with Cyclin A and/or Phosphorylation by Protein Kinase A.

Autor: Shinya Matsuda¹, Kyohei Kominato¹, Shizuyo Koide-Yoshida¹, Kenji Miyamoto¹, Kinuka Isshiki¹, Akihiko Tsuji¹, Keizo Yuasa¹ kyuasa@tokushima-u.ac.jp

Publikováno v: Journal of Biological Chemistry. 6/27/2014, Vol. 289 Issue 26, p18387-18400. 14p.

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