Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Kinston Sj"'
Autor:
Lewis Je, Lawrence J. Billing, Bertie Gottgens, Fiona M. Gribble, Christopher A. Smith, John Tadross, Kinston Sj, Cheryl A. Brighton, David Baker, Marco Tripodi, Hornigold D, Woodward Or, Benjamin U. Phillips, Ciabatti E, Alice E. Adriaenssens, Frank Reimann
Relaxin/insulin-like-family peptide receptor-4 (RXFP4), the cognate receptor for insulin-like peptide 5 (INSL5), has been implicated in feeding behaviour as Rxfp4 knockout mice display shorter meal durations and reduced high fat diet (HFD) intake. He
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d214b52ed8de0495597fbbef94a12b4d
https://doi.org/10.1101/2021.06.26.450020
https://doi.org/10.1101/2021.06.26.450020
Transcriptional dysregulation is associated with haematological malignancy. Although mutations of the key haematopoietic transcription factor PU.1 are rare in human acute myeloid leukaemia (AML), they are common in murine models of radiation-induced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______109::d8d814677ab751536aa6e5f2002fb2db
https://www.repository.cam.ac.uk/handle/1810/248682
https://www.repository.cam.ac.uk/handle/1810/248682
Autor:
Goldberg, L, Tijssen, MR, Birger, Y, Hannah, RL, Kinston, SJ, Schütte, J, Beck, D, Knezevic, K, Schiby, G, Jacob-Hirsch, J, Biran, A, Kloog, Y, Marcucci, G, Bloomfield, CD, Aplan, PD, Pimanda, JE, Göttgens, B, Izraeli, S
The ETS transcription factor ERG plays a central role in definitive hematopoiesis, and its overexpression in acute myeloid leukemia (AML) is associated with a stem cell signature and poor prognosis. Yet how ERG causes leukemia is unclear. Here we sho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______363::fd1457313f0eb9c72c9f4ed6b8d17dd2
https://hdl.handle.net/10453/116739
https://hdl.handle.net/10453/116739
Autor:
Beck, D, Thoms, JAI, Perera, D, Schütte, J, Unnikrishnan, A, Knezevic, K, Kinston, SJ, Wilson, NK, O'Brien, TA, Göttgens, B, Wong, JWH, Pimanda, JE
© 2013 by The American Society of Hematology. Genome-wide combinatorial binding patterns for key transcription factors (TFs) have not been reported for primary human hematopoietic stem and progenitor cells (HSPCs), and have constrained analysis of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______363::000f9ad0162498e14715e980dadbcd54
https://hdl.handle.net/10453/116740
https://hdl.handle.net/10453/116740
Akademický článek
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Autor:
Williams MJ; University of Cambridge, Cambridge, United Kingdom., Wang X; Shanghai Jiao Tong University School of Medicine, Shanghai, China., Bastos HP; University of Cambridge, Cambridge, United Kingdom., Grondys-Kotarba G; University of Cambridge, Cambridge, United Kingdom., Wu Q; University of Cambridge, Cambridge, United Kingdom., Jin S; University of Cambridge, Cambridge, United Kingdom., Johnson CS; University of Cambridge, Cambridge, United Kingdom., Mende N; University of Cambridge, Cambridge, United Kingdom., Calderbank EF; University of Cambridge, Cambridge, United Kingdom., Wantoch M; University of Cambridge, Cambridge, United Kingdom., Park HJ; University of Cambridge, Cambridge, United Kingdom., Mantica G; University of Cambridge, Cambridge, United Kingdom., Hannah RL; University of Cambridge, Cambridge, United Kingdom., Wilson NK; University of Cambridge, Cambridge, United Kingdom., Pask DC; Cambridge Institute for Medical Research, Cambridge, United Kingdom., Hamilton TL; CIMR, Cambridge, United Kingdom., Kinston SJ; University of Cambridge, Cambridge, United Kingdom., Asby R; University of Cambridge, Cambridge, United Kingdom., Sneade R; University of Cambridge, Cambridge, United Kingdom., Baxter EJ; University of Cambridge, Cambridge, United Kingdom., Campbell PJ; Wellcome Trust Sanger Institute, Cambridgeshire, United Kingdom., Vassiliou GS; University of Cambridge, Cambridge, United Kingdom., Laurenti E PhD; University of Cambridge, Cambridge, United Kingdom., Li J; University of Cambridge, Cambridge, United Kingdom., Gottgens B; University of Cambridge, Cambridge, United Kingdom., Green AR; University of Cambridge, Cambridge, United Kingdom.
Publikováno v:
Blood advances [Blood Adv] 2024 Oct 07. Date of Electronic Publication: 2024 Oct 07.
Autor:
Kucinski I; Wellcome-MRC Cambridge Stem Cell Institute, Department of Haematology, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK., Campos J; Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London EC1M 6BQ, UK; Institute of Cancer Research, London SM2 5NG, UK., Barile M; Wellcome-MRC Cambridge Stem Cell Institute, Department of Haematology, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK; Centre for Translational Stem Cell Biology, Hong Kong SAR, China., Severi F; Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4UU, UK; Wellcome Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 3BF, UK., Bohin N; Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London EC1M 6BQ, UK., Moreira PN; Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4UU, UK; Wellcome Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 3BF, UK., Allen L; Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London EC1M 6BQ, UK; Institute of Cancer Research, London SM2 5NG, UK., Lawson H; Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London EC1M 6BQ, UK; Institute of Cancer Research, London SM2 5NG, UK., Haltalli MLR; Wellcome-MRC Cambridge Stem Cell Institute, Department of Haematology, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK., Kinston SJ; Wellcome-MRC Cambridge Stem Cell Institute, Department of Haematology, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK., O'Carroll D; Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4UU, UK; Wellcome Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 3BF, UK. Electronic address: donal.ocarroll@ed.ac.uk., Kranc KR; Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London EC1M 6BQ, UK; Institute of Cancer Research, London SM2 5NG, UK. Electronic address: kamil.kranc@icr.ac.uk., Göttgens B; Wellcome-MRC Cambridge Stem Cell Institute, Department of Haematology, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK. Electronic address: bg200@cam.ac.uk.
Publikováno v:
Cell stem cell [Cell Stem Cell] 2024 Feb 01; Vol. 31 (2), pp. 244-259.e10. Date of Electronic Publication: 2024 Jan 05.
Autor:
Goh I; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.; Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK., Botting RA; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.; Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK., Rose A; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.; Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK., Webb S; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.; Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK., Engelbert J; Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK., Gitton Y; Sorbonne Université, INSERM, CNRS, Institut de la Vision, Paris, France., Stephenson E; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.; Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK., Quiroga Londoño M; Department of Haematology, Wellcome-MRC Cambridge Stem Cell Institute, Cambridge CB2 0AW, UK., Mather M; Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK., Mende N; Department of Haematology, Wellcome-MRC Cambridge Stem Cell Institute, Cambridge CB2 0AW, UK., Imaz-Rosshandler I; Department of Haematology, Wellcome-MRC Cambridge Stem Cell Institute, Cambridge CB2 0AW, UK.; MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Cambridge CD2 0QH, UK., Yang L; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK., Horsfall D; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.; Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK., Basurto-Lozada D; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.; Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK., Chipampe NJ; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK., Rook V; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK., Lee JTH; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK., Ton ML; Department of Haematology, Wellcome-MRC Cambridge Stem Cell Institute, Cambridge CB2 0AW, UK., Keitley D; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.; Department of Zoology, University of Cambridge, Cambridge CB2 3EJ, UK., Mazin P; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK., Vijayabaskar MS; Department of Haematology, Wellcome-MRC Cambridge Stem Cell Institute, Cambridge CB2 0AW, UK., Hannah R; Department of Haematology, Wellcome-MRC Cambridge Stem Cell Institute, Cambridge CB2 0AW, UK., Gambardella L; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK., Green K; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK., Ballereau S; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK., Inoue M; Sorbonne Université, INSERM, CNRS, Institut de la Vision, Paris, France., Tuck E; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK., Lorenzi V; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK., Kwakwa K; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK., Alsinet C; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.; Centre Nacional d'Analisi Genomica-Centre de Regulacio Genomica (CNAG-CRG), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain., Olabi B; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.; Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK., Miah M; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.; Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK., Admane C; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.; Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK., Popescu DM; Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK., Acres M; Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK., Dixon D; Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK., Ness T; NovoPath, Department of Pathology, Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne NE1 4LP, UK., Coulthard R; NovoPath, Department of Pathology, Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne NE1 4LP, UK., Lisgo S; Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK., Henderson DJ; Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK., Dann E; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK., Suo C; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK., Kinston SJ; Department of Haematology, Wellcome-MRC Cambridge Stem Cell Institute, Cambridge CB2 0AW, UK., Park JE; Korea Advanced Institute of Science and Technology, Daejeon, South Korea., Polanski K; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK., Marioni J; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.; EMBL-EBI, Wellcome Genome Campus, Cambridge CB10 1SD, UK.; CRUK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, UK., van Dongen S; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK., Meyer KB; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK., de Bruijn M; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DS, UK., Palis J; Department of Pediatrics, University of Rochester Medical Center, Rochester, NY 14642, USA., Behjati S; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.; Department of Paediatrics, University of Cambridge, Cambridge CB2 0QQ, UK., Laurenti E; Department of Haematology, Wellcome-MRC Cambridge Stem Cell Institute, Cambridge CB2 0AW, UK., Wilson NK; Department of Haematology, Wellcome-MRC Cambridge Stem Cell Institute, Cambridge CB2 0AW, UK., Vento-Tormo R; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK., Chédotal A; Sorbonne Université, INSERM, CNRS, Institut de la Vision, Paris, France., Bayraktar O; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK., Roberts I; Department of Paediatrics, University of Oxford, Oxford OX3 9DS, UK., Jardine L; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.; Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK., Göttgens B; Department of Haematology, Wellcome-MRC Cambridge Stem Cell Institute, Cambridge CB2 0AW, UK., Teichmann SA; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.; Theory of Condensed Matter Group, Department of Physics, Cavendish Laboratory, University of Cambridge, Cambridge CB3 0HE, UK., Haniffa M; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.; Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.; Department of Dermatology and NIHR Newcastle Biomedical Research Centre, Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne NE1 4LP, UK.
Publikováno v:
Science (New York, N.Y.) [Science] 2023 Aug 18; Vol. 381 (6659), pp. eadd7564. Date of Electronic Publication: 2023 Aug 18.
Autor:
Wang M; Division of Nutritional Sciences, Cornell University, Ithaca, NY, USA; Wellcome-MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK; MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, UK. Electronic address: mengwang@cornell.edu., Brandt LTL; MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, UK., Wang X; Wellcome-MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK; School of Public Health, Shanghai Jiaotong University School of Medicine, Shanghai, China., Russell H; MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK., Mitchell E; Wellcome-MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK; Wellcome Sanger Institute, Hinxton, UK., Kamimae-Lanning AN; MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK., Brown JM; MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK., Dingler FA; MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK., Garaycoechea JI; Hubrecht Institute-KNAW (Royal Netherlands Academy of Arts and Sciences) and University Medical Center, Utrecht, the Netherlands., Isobe T; Wellcome-MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK., Kinston SJ; Wellcome-MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK., Gu M; Wellcome-MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK., Vassiliou GS; Wellcome-MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK., Wilson NK; Wellcome-MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK., Göttgens B; Wellcome-MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK., Patel KJ; MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK. Electronic address: ketan.patel@imm.ox.ac.uk.
Publikováno v:
Molecular cell [Mol Cell] 2023 Jul 20; Vol. 83 (14), pp. 2417-2433.e7. Date of Electronic Publication: 2023 Jun 21.
Autor:
Lewis JE; Wellcome Trust - MRC Institute of Metabolic Science Metabolic Research Laboratories, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 0QQ, UK. Electronic address: jl2033@medschl.cam.ac.uk., Woodward OR; Wellcome Trust - MRC Institute of Metabolic Science Metabolic Research Laboratories, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 0QQ, UK., Nuzzaci D; Wellcome Trust - MRC Institute of Metabolic Science Metabolic Research Laboratories, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 0QQ, UK., Smith CA; Wellcome Trust - MRC Institute of Metabolic Science Metabolic Research Laboratories, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 0QQ, UK., Adriaenssens AE; Wellcome Trust - MRC Institute of Metabolic Science Metabolic Research Laboratories, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 0QQ, UK., Billing L; Wellcome Trust - MRC Institute of Metabolic Science Metabolic Research Laboratories, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 0QQ, UK., Brighton C; Wellcome Trust - MRC Institute of Metabolic Science Metabolic Research Laboratories, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 0QQ, UK., Phillips BU; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK., Tadross JA; Wellcome Trust - MRC Institute of Metabolic Science Metabolic Research Laboratories, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 0QQ, UK; Department of Pathology, University of Cambridge, Cambridge CB2 1QP, UK., Kinston SJ; Department of Haematology, Wellcome and MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK., Ciabatti E; Department of Haematology, Wellcome and MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK., Göttgens B; Department of Haematology, Wellcome and MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK., Tripodi M; MRC Laboratory of Molecular Biology, Neurobiology Division, Francis Crick Avenue, Cambridge CB2 0QH, UK., Hornigold D; Research and Early Development Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca Ltd, Cambridge, UK., Baker D; Research and Early Development Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca Ltd, Cambridge, UK., Gribble FM; Wellcome Trust - MRC Institute of Metabolic Science Metabolic Research Laboratories, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 0QQ, UK. Electronic address: fmg23@cam.ac.uk., Reimann F; Wellcome Trust - MRC Institute of Metabolic Science Metabolic Research Laboratories, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 0QQ, UK. Electronic address: fr222@cam.ac.uk.
Publikováno v:
Molecular metabolism [Mol Metab] 2022 Dec; Vol. 66, pp. 101604. Date of Electronic Publication: 2022 Sep 30.