Development of Clostridium difficile R20291ΔPaLoc model strains and in vitro methodologies reveals CdtR is required for the production of CDT to cytotoxic levels.

Autor: Bilverstone TW; Clostridia Research Group, BBSRC/EPSRC Synthetic Biology Research Centre (SBRC), School of Life Sciences, Centre for Biomolecular Sciences, The University of Nottingham, Nottingham, NG7 2RD, UK., Kinsmore NL; Clostridia Research Group, BBSRC/EPSRC Synthetic Biology Research Centre (SBRC), School of Life Sciences, Centre for Biomolecular Sciences, The University of Nottingham, Nottingham, NG7 2RD, UK; NIHR Nottingham Digestive Diseases, (NDCC) Biomedical Research Unit, Nottingham University Hospitals NHS Trust and the University of Nottingham, NG7 2RD, UK., Minton NP; Clostridia Research Group, BBSRC/EPSRC Synthetic Biology Research Centre (SBRC), School of Life Sciences, Centre for Biomolecular Sciences, The University of Nottingham, Nottingham, NG7 2RD, UK; NIHR Nottingham Digestive Diseases, (NDCC) Biomedical Research Unit, Nottingham University Hospitals NHS Trust and the University of Nottingham, NG7 2RD, UK. Electronic address: nigel.minton@nottingham.ac.uk., Kuehne SA; Clostridia Research Group, BBSRC/EPSRC Synthetic Biology Research Centre (SBRC), School of Life Sciences, Centre for Biomolecular Sciences, The University of Nottingham, Nottingham, NG7 2RD, UK; NIHR Nottingham Digestive Diseases, (NDCC) Biomedical Research Unit, Nottingham University Hospitals NHS Trust and the University of Nottingham, NG7 2RD, UK.

Publikováno v: Anaerobe [Anaerobe] 2017 Apr; Vol. 44, pp. 51-54. Date of Electronic Publication: 2017 Jan 17.

The glucosyltransferase activity of C. difficile Toxin B is required for disease pathogenesis.

Autor: Bilverstone, Terry W.¹ (AUTHOR), Garland, Megan^2,3 (AUTHOR), Cave, Rory J.¹ (AUTHOR), Kelly, Michelle L.¹ (AUTHOR), Tholen, Martina³ (AUTHOR), Bouley, Donna M.⁴ (AUTHOR), Kaye, Philip⁵ (AUTHOR), Minton, Nigel P.^1,6 (AUTHOR), Bogyo, Matthew^3,7 (AUTHOR), Kuehne, Sarah A.⁸ (AUTHOR) s.a.kuehne@bham.ac.uk, Melnyk, Roman A.⁹ (AUTHOR) s.a.kuehne@bham.ac.uk

Publikováno v: PLoS Pathogens. 9/22/2020, Vol. 16 Issue 9, p1-16. 16p.

Clostridioides difficile exploits toxin-mediated inflammation to alter the host nutritional landscape and exclude competitors from the gut microbiota.

Autor: Fletcher, Joshua R., Pike, Colleen M., Parsons, Ruth J., Rivera, Alissa J., Foley, Matthew H., McLaren, Michael R., Montgomery, Stephanie A., Theriot, Casey M.

Publikováno v: Nature Communications; 1/19/2021, Vol. 12 Issue 1, p1-14, 14p