A novel mitochondrial pyruvate carrier inhibitor drives stem cell-like memory CAR T cell generation and enhances antitumor efficacy

Autor: Mathias Wenes, Anouk Lepez, Vladimir Arinkin, Kinsey Maundrell, Orsolya Barabas, Federico Simonetta, Valérie Dutoit, Pedro Romero, Jean-Claude Martinou, Denis Migliorini

Publikováno v: Molecular Therapy: Oncology, Vol 32, Iss 4, Pp 200897- (2024)

Adoptive cell transfer with chimeric antigen receptor (CAR)-expressing T cells can induce remarkable complete responses in cancer patients. Therapeutic success has been correlated with central and stem cell-like memory T cell subsets in the infusion

Externí odkaz: https://doaj.org/article/7ba4b4c02c104d69af18e040907089f6

FASTKD1 and FASTKD4 have opposite effects on expression of specific mitochondrial RNAs, depending upon their endonuclease-like RAP domain

Autor: Alexis A. Jourdain, Erik Boehm, Jean-Claude Martinou, Kinsey Maundrell, Stéphane Thore, Sofia Zaganelli

Publikováno v: Nucleic Acids Research
Nucleic Acids Research, Oxford University Press, 2017, 45 (10), pp.6135-6146. ⟨10.1093/nar/gkx164⟩
Nucleic acids research, vol. 45, no. 10, pp. 6135-6146

FASTK family proteins have been identified as regulators of mitochondrial RNA homeostasis linked to mitochondrial diseases, but much remains unknown about these proteins. We show that CRISPR-mediated disruption of FASTKD1 increases ND3 mRNA level, wh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9b1928c183bf58555a235bd024046e3
https://hal.archives-ouvertes.fr/hal-02472346

Mitochondrial RNA granules: Compartmentalizing mitochondrial gene expression

Autor: Jean-Claude Martinou, Erik Boehm, Kinsey Maundrell, Alexis A. Jourdain

Publikováno v: The Journal of Cell Biology
The Journal of cell biology, vol. 212, no. 6, pp. 611-614

In mitochondria, DNA replication, gene expression, and RNA degradation machineries coexist within a common nondelimited space, raising the question of how functional compartmentalization of gene expression is achieved. Here, we discuss the recently c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9edc07d3f8dc4db8da734594b639e21b
https://pubmed.ncbi.nlm.nih.gov/26953349

Identification and Characterization of the Translationally Repressed Cytoplasmic Globin Messenger-Ribonucleoprotein Particles from Duck Erythroblasts

Autor: Olivier Civelli, Klaus Scherrer, Kinsey Maundrell, Alain Vincent

Publikováno v: European Journal of Biochemistry. 112:617-633

Globin messenger ribonucleoprotein (mRNP) particles which have been isolated from duck erythroblast post-polyribosomal supernatant are translationally inactive in vivo and in vitro but contain translatable mRNA active after deproteinisation. They wer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de52a7f6439f93e1a82160dc269b5734
https://doi.org/10.1111/j.1432-1033.1980.tb06127.x

Caspase-12 and endoplasmic reticulum stress mediate neurotoxicity of pathological prion protein

Autor: Kinsey Maundrell, Joaquín Castilla, Milene Russelakis-Carneiro, Claudio Soto, Claudio Hetz

Publikováno v: EMBO J

Prion diseases are characterized by accumulation of misfolded prion protein (PrP(Sc)), and neuronal death by apoptosis. Here we show that nanomolar concentrations of purified PrP(Sc) from mouse scrapie brain induce apoptosis of N2A neuroblastoma cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cef19b082913cf26d5fcef4f281c382c
https://doi.org/10.1093/emboj/cdg537