Pharmacokinetic Modeling to Guide Preclinical Development of an Islatravir-Eluting Reservoir-Style Biodegradable Implant for Long-Acting HIV PrEP.

Autor: Kinsale TS; Division of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA., Cottrell ML; Division of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA., Li L; Biomedical Technologies RTI International, 3040 E. Cornwallis Road, Research Triangle Park, NC 27709, USA., Brand R; Magee-Womens Research Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA., Gatto G; Global Public Health Impact Center, RTI International, Research Triangle Park, NC 27709, USA., Luecke E; Global Public Health Impact Center, RTI International, Research Triangle Park, NC 27709, USA., Norton C; Biomedical Technologies RTI International, 3040 E. Cornwallis Road, Research Triangle Park, NC 27709, USA., Krovi A; Biomedical Technologies RTI International, 3040 E. Cornwallis Road, Research Triangle Park, NC 27709, USA., Dumond JB; Division of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA., Rao G; Division of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA., Yeshwante S; Division of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA., Van Horne B; Division of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA., Van Der Straten A; Center for AIDS Prevention Studies (CAPS), Department of Medicine, University of California San Francisco, San Francisco, CA 94104, USA.; ASTRA Consulting, Kensington, CA 94708, USA., Kashuba ADM; Division of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA., Johnson LM; Biomedical Technologies RTI International, 3040 E. Cornwallis Road, Research Triangle Park, NC 27709, USA.

Publikováno v: Pharmaceutics [Pharmaceutics] 2024 Jan 30; Vol. 16 (2). Date of Electronic Publication: 2024 Jan 30.