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Glucocorticoids and B Cell Depleting Agents Substantially Impair Immunogenicity of mRNA Vaccines to SARS-CoV-2.

Autor: Deepak P; Inflammatory Bowel Diseases Center, Division of Gastroenterology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA., Kim W; Division of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Paley MA; Division of Rheumatology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA., Yang M; Division of Rheumatology, Department of Medicine, University of California San Francisco, San Francisco, CA, USA., Carvidi AB; Division of Rheumatology, Department of Medicine, University of California San Francisco, San Francisco, CA, USA., El-Qunni AA; Division of Rheumatology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA., Haile A; Clinical Trials Unit, Washington University School of Medicine, St. Louis, MO, USA., Huang K; Division of Gastroenterology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA., Kinnett B; Division of Gastroenterology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA., Liebeskind MJ; Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA., Liu Z; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA., McMorrow LE; Division of Rheumatology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA., Paez D; Division of Rheumatology, Department of Medicine, University of California San Francisco, San Francisco, CA, USA., Perantie DC; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA., Schriefer RE; Division of Rheumatology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA., Sides SE; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA., Thapa M; Division of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Gergely M; Division of Gastroenterology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA., Abushamma S; Division of Gastroenterology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA., Klebert M; Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA., Mitchell L; Division of Rheumatology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA., Nix D; Division of Gastroenterology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA., Graf J; Division of Rheumatology, Department of Medicine, University of California San Francisco, San Francisco, CA, USA., Taylor KE; Division of Rheumatology, Department of Medicine, University of California San Francisco, San Francisco, CA, USA., Chahin S; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA., Ciorba MA; Inflammatory Bowels Diseases Center, Division of Gastroenterology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA., Katz P; Division of Rheumatology, Department of Medicine, University of California San Francisco, San Francisco, CA, USA., Matloubian M; Division of Rheumatology, Department of Medicine, University of California San Francisco, San Francisco, CA, USA., O'Halloran JA; Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA., Presti RM; Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA., Wu GF; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA; Division of Immunobiology, Department of Pathology and Immunology, Washington, University School of Medicine, St. Louis, MO, USA; The Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO, USA., Whelan SPJ; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA., Buchser WJ; Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA., Gensler LS; Division of Rheumatology, Department of Medicine, University of California San Francisco, San Francisco, CA, USA; Arthritis/Immunology Section, San Francisco Veterans Administration Health Care System, San Francisco, CA, USA., Nakamura MC; Division of Rheumatology, Department of Medicine, University of California San Francisco, San Francisco, CA, USA; Arthritis/Immunology Section, San Francisco Veterans Administration Health Care System, San Francisco, CA, USA., Ellebedy AH; Division of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA; The Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO, USA., Kim AHJ; Division of Rheumatology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA; Division of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA; The Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO, USA.

Publikováno v: MedRxiv : the preprint server for health sciences [medRxiv] 2021 Apr 09. Date of Electronic Publication: 2021 Apr 09.