A novel role for nucleolin in splice site selection

Autor: Kinneret Shefer, Ayub Boulos, Valer Gotea, Maram Arafat, Yair Ben Chaim, Aya Muharram, Sara Isaac, Amir Eden, Joseph Sperling, Laura Elnitski, Ruth Sperling

Publikováno v: RNA biology. 19(1)

Latent 5' splice sites, not normally used, are highly abundant in human introns, but are activated under stress and in cancer, generating thousands of nonsense mRNAs. A previously proposed mechanism to suppress latent splicing was shown to be indepen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a5f0a51ac6601803349988127351d3d
https://pubmed.ncbi.nlm.nih.gov/35220879

Abstract CT147: Celiac plexus radiosurgery a new palliative modality for upper gastrointestinal malignancies - final quality of life results from a proof-of-concept clinical trial

Autor: Ilana Weiss, Kinneret Shefer, T. Katzman, Liat Hammer, Maoz Ben-Ailan, Yaacov Richard Lawrence, Ofer Margalit, Zvi Symon, Uri Amit, Inessa Yanovsky, Talia Golan, David Hausner, Einat Shacham Shmueli, Galia Jacobson, Ofir Morag, Ben Boursi, Naama Halpern, D. Alezra, Adam P. Dicker

Publikováno v: Cancer Research. 79:CT147-CT147

Background: Many patients with upper-abdominal malignancies suffer from severe low back / epigastric pain caused by infiltration of the celiac plexus. The celiac plexus is a network of nociceptive nerves, located along the aorta. Contemporary approac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::73dc3e4f6ead5c2bd855af25535b105a
https://doi.org/10.1158/1538-7445.am2019-ct147

Safer one-pot synthesis of the ‘SHAPE’ reagent 1-methyl-7-nitroisatoic anhydride (1m7)

Autor: Manuel Ares, Rushia A. Turner, Kinneret Shefer

Publikováno v: Turner, R; Shefer, K; & Ares, M. (2013). Safer one-pot synthesis of the 'SHAPE' reagent 1-methyl-7-nitroisatoic anhydride (1m7). RNA, 19(12), 1857-1863. doi: 10.1261/rna.042374.113. UC Santa Cruz: Retrieved from: http://www.escholarship.org/uc/item/6926z4c8
RNA (New York, N.Y.), vol 19, iss 12

Estimating the reactivity of 2′-hydroxyl groups along an RNA chain of interest aids in the modeling of the folded RNA structure; flexible loops tend to be reactive, whereas duplex regions are generally not. Among the most useful reagents for probin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c191fc724d91acbcb0dbc7946306fcda
https://doi.org/10.1261/rna.042374.113

A Triple Helix within a Pseudoknot Is a Conserved and Essential Element of Telomerase RNA

Autor: Yogev Brown, Kinneret Shefer, Yehuda Tzfati, Valentin Gorkovoy, Tamar Nussbaum, Nikolai B. Ulyanov

Publikováno v: Molecular and Cellular Biology. 27:2130-2143

Telomerase copies a short template within its integral telomerase RNA onto eukaryotic chromosome ends, compensating for incomplete replication and degradation. Telomerase action extends the proliferative potential of cells, and thus it is implicated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b9ed5ddfc46d61a4d10322212aa86ae
https://doi.org/10.1128/mcb.01826-06

The Supraspliceosome — A Multi-Task Machine for Regulated Pre-mRNA Processing in the Cell Nucleus

Autor: Ruth Sperling, Kinneret Shefer, Joseph Sperling

Publikováno v: Computational and Structural Biotechnology Journal, Vol 11, Iss 19, Pp 113-122 (2014)
Computational and Structural Biotechnology Journal

Pre-mRNA splicing of Pol II transcripts is executed in the mammalian cell nucleus within a huge (21MDa) and highly dynamic RNP machine — the supraspliceosome. It is composed of four splicing active native spliceosomes, each resembling an in vitro a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::996420b17320a04bd01abd0c5e11f30b