Hypomethylation of CD30 CpG islands with aberrant JunB expression drives CD30 induction in Hodgkin lymphoma and anaplastic large cell lymphoma

Autor: Masaaki Higashihara, Tukasa Koiwa, Marshall E. Kadin, Isao Okayasu, Mariko Watanabe, Toshiki Watanabe, Yuji Ogawa, Kinji Itoh, Ryouichi Horie

Publikováno v: Laboratory Investigation. 88:48-57

High expression of CD30 and JunB is the hallmark of malignant cells in Hodgkin lymphoma (HL) and anaplastic large cell lymphoma (ALCL). Ligand-independent signaling by CD30 induces JunB, which activates the CD30 promoter, stabilizing CD30 expression

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8cc937039c0fd92c778c8c1fad05c11
https://doi.org/10.1038/labinvest.3700696

A novel NF-?B inhibitor DHMEQ selectively targets constitutive NF-?B activity and induces apoptosis of multiple myeloma cellsin vitro andin vivo

Autor: Naoki Yamamoto, Masaaki Higashihara, Masataka Sasaki, Md. Zahidunnabi Dewan, Mitsuo Honda, Mariko Watanabe, Hideaki Mizoguchi, Kazuo Umezawa, Kinji Itoh, Toshiki Watanabe, Takamitu Okamura, Ryouichi Horie, Testutaro Sata

Publikováno v: International Journal of Cancer. 114:32-38

Multiple myeloma (MM) is a fatal lymphoid malignancy that is incurable with conventional modalities of chemotherapy. Strong and constitutive activation of nuclear factor kappa B (NF-kappaB) is a common characteristic of MM cells. In our study we succ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc40933fa036778d4afee4f6b0cb5685
https://doi.org/10.1002/ijc.20688

Activation of Akt involves resistance to NF-κB inhibition and abrogation of both triggers synergistic apoptosis in lung adenocarcinoma cells

Autor: Mariko Watanabe, Kazuo Umezawa, Noriyuki Masuda, Tomiteru Togano, Masaaki Higashihara, Ryouichi Horie, Kinji Itoh

Publikováno v: Lung cancer (Amsterdam, Netherlands). 83(2)

Objectives Although nuclear factor (NF)-κB and phosphoinositide 3-kinase (PI3K)-Akt-mTOR comprise key pathways, their interrelationship in lung cancer cell survival is poorly understood and needs further analyses. Materials and methods We examined t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba56db456d3f6fb82c2aed26c8b1f3ed
https://pubmed.ncbi.nlm.nih.gov/24331410

GENERAL SESSION

Autor: Takeo Aida, Shinichi Urata, Tatsuo Oquro, Yoshihiro AKIMOTO, Akiko OBINATA, Yuko ODA, Hiroyoshi ENDO, Ken-ichi KASAI, Hiroshi HIRANO, Toshihiro AOKI, Tsutomu OINUMA, Junichi KAWANO, Tatsuo SUGANUMA, Ryohachi Arai, Yasuji Kojima, Toshihiro Maeda, M. Arakawa, A. Mizoguchi, E. Fujimoto, A. Miki, C. Ide, Nobukazu ARAKI, Yoichiro TAKASHIMA, Kazuo OGAWA, Tsutomu ARAKI, C.K. Chang, Y. Ogawa, H. Kuwahara, T. Yagi, Kohsuke CHIDA, Kensuke CHIKAMORI, Yong-xi CUI, Kazushige KIGUCHI, Shirou NOZAWA, Masao IWAMORI, Yoshitaka NAGAI, Hayato KAWAKAMI, T. DAIMON, K. KAWAI, K. UCHIDA, Fumiko DATE, Hironobu SASANO, Hiroshi NAGURA, Kazushige DOBASHI, Afreen MUNIM, Kohtaro ASAYAMA, Koichi SUZUKI, Kiyohiko KATO, Akira KAWAOI, Hisashi ENDO, Gotaro YAMADA, Hiroshi NISHIMOTO, Takao TSUJI, Paul K. NAKANE, Tetsuya FUJII, Kaoru KOMORI, Masao SAKAI, Keiki YAMADA, Nobuyuki KARASAWA, Ikuko NAGATSU, Toyoshi FUJIMOTO, Shinji NAKADE, Katsuhiko MIKOSHIBA, Kuniaki FUKUDA, Masaharu FUKAMI, Makoto FUKUI, Kumiko KIMURA, Yan QIAO, Junzo MURATA, Goro ASANO, Toru HANAI, Nobuteru USUDA, Takashi MORITA, Yonuli KONG, Tetsuji NAGATA, Takayuki HARADA, Koichi HASHIMOTO, Ikuko TORII, Shigeru MORIKAWA, Masashi HAREYAMA, Kazushi FUJIMOTO, Yoshihito HONDA, Makoto HIRAKAWA, Mitsuhiro KAWATA, Yayoi HIROSE, Masahito WATANABE, Masahisa SHIMADA, K. IHIDA, S. TSUYAMA, N. NASHIO, F. MURATA, T. KATSUYAMA, H. OHTA, Kikuko IMAMOTO, Ikuko NAGATU, K. Inada, H. Utunomiya, K. Sato, R.Y. Osamura, H. Katakami, K. Mayo, Toshimitsu ISHIBASHI, Kyotaro KANAZAWA, Takuma SAITO, Nobuaki ITO, Shingo KAWAHARA, Yoshinari HIRANO, Tadaomi HIROTA, Atsuko ITOH, Kinji ITOH, Tomoko TAKESHITA, Masamichi ITOH, J. Itoh, K. Watanabe, Y. Itoh, N. Komatsu, H. Angeletti, Atsuko ITO-SAITO, Naoaki SAITO, Takeo MATSUMURA, Chikako TANAKA, Masunobu IWAMOTO, Jun WATANABE, Mari ASADA-KUBOTA, Shinsuke KANAMURA

Publikováno v: ACTA HISTOCHEMICA ET CYTOCHEMICA. 24:508-516

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6153431429d3f2a0f91c8f919cbc0c38
https://doi.org/10.1267/ahc.24.508

Aberrant NF-κB2/p52 expression in Hodgkin/Reed–Sternberg cells and CD30-transformed rat fibroblasts.

Autor: Mizuho Nonaka, Ryouichi Horie, Kinji Itoh, Toshiki Watanabe, Naoki Yamamoto, Shoji Yamaoka

Publikováno v: Oncogene; 6/2/2005, Vol. 24 Issue 24, p3976-3986, 11p