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Abstract 1308: Development and validation of a flow cytometric assay for measuring glycoprotein A repetitions predominant protein GARP target engagement by ABBV-151

Autor: Jayaprakash Kotha, Michelle Graham, Lisa K. Jennings, Stacie Lambert, Sridevi Kotha, Juan M Cardenas, Kinjal Hew

Publikováno v: Cancer Research. 81:1308-1308

Introduction: GARP is a cell surface protein expressed post activation on regulatory T-cells (Treg), monocytes, B cells, and platelets. GARP binds to latent transforming growth factor beta (TGF-β1) and regulates the release of active TGF-β1. TGF-β

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1b6fa1305cf5e82ff0fe7c78608491b2
https://doi.org/10.1158/1538-7445.am2021-1308

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Abstract 5672: Pharmacodynamics and potential predictive biomarkers of ABBV-428, a first-in-class mesothelin (MSLN)-CD40 bispecific, in patients with advanced solid tumors

Autor: Tolga Turan, Shiming Ye, Anita Reddy, Andrew Woolley, Joel S Hayflick, William R Henner, Debra Chao, Kathryn Allaire, Hua Fang, Cyril Ramathal, Michael A. McDevitt, Frances Fan, Lawrence Fong, Kinjal Hew

Publikováno v: Cancer Research. 80:5672-5672

Background: ABBV-428 is a first-in-class bispecific antibody against CD40 and MSLN designed to stimulate CD40 for tumor-specific immune activation with limited systemic toxicity (Cancer Immunol Res 2019;7:1864). In phase I findings, ABBV-428 was well

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::816153de7f91d6d35fb0c6138a1bbf4f
https://doi.org/10.1158/1538-7445.am2020-5672

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