Zobrazeno 1 - 10
of 268
pro vyhledávání: '"Kinichi Nakashima"'
Publikováno v:
Epigenomes, Vol 8, Iss 2, p 22 (2024)
The development of the nervous system is regulated by numerous intracellular molecules and cellular signals that interact temporally and spatially with the extracellular microenvironment. The three major cell types in the brain, i.e., neurons and two
Externí odkaz:
https://doaj.org/article/84e450d439df4e00b7b85d00a231afae
Publikováno v:
Cells, Vol 13, Iss 8, p 707 (2024)
Although lineage reprogramming from one cell type to another is becoming a breakthrough technology for cell-based therapy, several limitations remain to be overcome, including the low conversion efficiency and subtype specificity. To address these, m
Externí odkaz:
https://doaj.org/article/4914823d1b43406288cba6a219f16f02
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Several transcription factors, including NeuroD1, have been shown to act as neuronal reprogramming factors (RFs) that induce neuronal conversion from somatic cells. However, it remains unexplored whether expression levels of RFs in the origi
Externí odkaz:
https://doaj.org/article/d984995b1ef340069f08a6a5d654033c
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
Epilepsy is a chronic neurological disorder characterized by hypersynchronous spontaneous recurrent seizures, and affects approximately 50 million people worldwide. Cumulative evidence has revealed that epileptogenic insult temporarily increases neur
Externí odkaz:
https://doaj.org/article/89459b618de14e6c9f3e37111963e407
Autor:
Tomonori KAMEDA, Hideyuki NAKASHIMA, Takumi TAKIZAWA, Fumihito MIURA, Takashi ITO, Kinichi NAKASHIMA, Takuya IMAMURA
Publikováno v:
The Journal of Reproduction and Development, Vol 67, Iss 6, Pp 369-379 (2021)
Post-mitotic neurons do exhibit DNA methylation changes, contrary to the longstanding belief that the epigenetic pattern in terminally differentiated cells is essentially unchanged. While the mechanism and physiological significance of DNA demethylat
Externí odkaz:
https://doaj.org/article/05bf0e296b3d45e495e3c006aa04c7f3
Publikováno v:
Pharmacology Research & Perspectives, Vol 9, Iss 6, Pp n/a-n/a (2021)
Abstract The brain consists of three major cell types: neurons and two glial cell types (astrocytes and oligodendrocytes). Although they are generated from common multipotent neural stem/precursor cells (NS/PCs), embryonic NS/PCs cannot generate all
Externí odkaz:
https://doaj.org/article/df802f33d6454cdd93e209a95c654f5c
Growth factors with valproic acid restore injury-impaired hearing by promoting neuronal regeneration
Autor:
Takahiro Wakizono, Hideyuki Nakashima, Tetsuro Yasui, Teppei Noda, Kei Aoyagi, Kanako Okada, Yasuhiro Yamada, Takashi Nakagawa, Kinichi Nakashima
Publikováno v:
JCI Insight, Vol 6, Iss 22 (2021)
Spiral ganglion neurons (SGNs) are primary auditory neurons in the spiral ganglion that transmit sound information from the inner ear to the brain and play an important role in hearing. Impairment of SGNs causes sensorineural hearing loss (SNHL), and
Externí odkaz:
https://doaj.org/article/b9e5695f8d1840c0afc707ee61da6105
Autor:
Hideyuki Nakashima, Keita Tsujimura, Koichiro Irie, Takuya Imamura, Cleber A. Trujillo, Masataka Ishizu, Masahiro Uesaka, Miao Pan, Hirofumi Noguchi, Kanako Okada, Kei Aoyagi, Tomoko Andoh-Noda, Hideyuki Okano, Alysson R. Muotri, Kinichi Nakashima
Publikováno v:
Cell Reports, Vol 35, Iss 7, Pp 109124- (2021)
Summary: Rett syndrome (RTT) is a severe neurological disorder, with impaired brain development caused by mutations in MECP2; however, the underlying mechanism remains elusive. We know from previous work that MeCP2 facilitates the processing of a spe
Externí odkaz:
https://doaj.org/article/0fed81b11b5247d3a98746060e307b29
Autor:
Tsukasa Sanosaka, Takuya Imamura, Nobuhiko Hamazaki, MuhChyi Chai, Katsuhide Igarashi, Maky Ideta-Otsuka, Fumihito Miura, Takashi Ito, Nobuyuki Fujii, Kazuho Ikeo, Kinichi Nakashima
Publikováno v:
Cell Reports, Vol 20, Iss 12, Pp 2992-3003 (2017)
Regulation of the epigenome during in vivo specification of brain stem cells is still poorly understood. Here, we report DNA methylome analyses of directly sampled cortical neural stem and progenitor cells (NS/PCs) at different development stages, as
Externí odkaz:
https://doaj.org/article/7307e17fc6104150a6a5bd980b5663d6
Autor:
Rebecca Brulet, Taito Matsuda, Ling Zhang, Carlos Miranda, Mauro Giacca, Brian K. Kaspar, Kinichi Nakashima, Jenny Hsieh
Publikováno v:
Stem Cell Reports, Vol 8, Iss 6, Pp 1506-1515 (2017)
Currently, all methods for converting non-neuronal cells into neurons involve injury to the brain; however, whether neuronal transdifferentiation can occur long after the period of insult remains largely unknown. Here, we use the transcription factor
Externí odkaz:
https://doaj.org/article/d22afb285af14f2283106a4825715274