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pro vyhledávání: '"Kingston King-Shi Mok"'
Autor:
Kingston King‐Shi Mok, Sunny Hoi‐Sang Yeung, Gerald Wai‐Yeung Cheng, Iris Wai‐Ting Ma, Ralph Hon‐Sun Lee, Karl Herrup, Kai‐Hei Tse
Publikováno v:
Journal of neurochemistry.
Carriers of the APOE4 (Apolipoprotein E ε4) variant of the APOE gene are subject to several age-related health risks, including Alzheimer's disease (AD). The deficient lipid and cholesterol transport capabilities of the APOE4 protein are one reason
Autor:
Gerald Wai-Yeung Cheng, Kingston King-Shi Mok, Sunny Hoi-Sang Yeung, Julia Kofler, Karl Herrup, Kai-Hei Tse
Publikováno v:
J Neuropathol Exp Neurol
White matter degradation in the frontal lobe is one of the earliest detectable changes in aging and Alzheimer disease. The ε4 allele of apolipoprotein E (APOE4) is strongly associated with such myelin pathology but the underlying cellular mechanisms