Zobrazeno 1 - 10
of 313
pro vyhledávání: '"Kingston H. G. Mills"'
Autor:
Tristram A. J. Ryan, Alexander Hooftman, Aisling M. Rehill, Matt D. Johansen, Eóin C. O’ Brien, Juliana E. Toller-Kawahisa, Mieszko M. Wilk, Emily A. Day, Hauke J. Weiss, Pourya Sarvari, Emilio G. Vozza, Fabian Schramm, Christian G. Peace, Alessia Zotta, Stefan Miemczyk, Christina Nalkurthi, Nicole G. Hansbro, Gavin McManus, Laura O’Doherty, Siobhan Gargan, Aideen Long, Jean Dunne, Clíona Ní Cheallaigh, Niall Conlon, Michael Carty, Padraic G. Fallon, Kingston H. G. Mills, Emma M. Creagh, James S. O’ Donnell, Paul J. Hertzog, Philip M. Hansbro, Rachel M. McLoughlin, Małgorzata Wygrecka, Roger J. S. Preston, Zbigniew Zasłona, Luke A. J. O’Neill
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Excessive inflammation-associated coagulation is a feature of infectious diseases, occurring in such conditions as bacterial sepsis and COVID-19. It can lead to disseminated intravascular coagulation, one of the leading causes of mortality w
Externí odkaz:
https://doaj.org/article/0df3d79819534a4786cd65226889c413
Autor:
Béré K. Diallo, Caitlín Ní Chasaide, Ting Y. Wong, Pauline Schmitt, Katherine S. Lee, Kelly Weaver, Olivia Miller, Melissa Cooper, Seyed D. Jazayeri, F. Heath Damron, Kingston H. G. Mills
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-13 (2023)
Abstract Current COVID-19 vaccines prevent severe disease, but do not induce mucosal immunity or prevent infection with SARS-CoV-2, especially with recent variants. Furthermore, serum antibody responses wane soon after immunization. We assessed the i
Externí odkaz:
https://doaj.org/article/f0f15032a6664cdd9a63260d9984623e
Autor:
Mariana P. Cervantes-Silva, Richard G. Carroll, Mieszko M. Wilk, Diana Moreira, Cloe A. Payet, James R. O’Siorain, Shannon L. Cox, Lauren E. Fagan, Paula A. Klavina, Yan He, Tabea Drewinski, Alan McGinley, Sharleen M. Buel, George A. Timmons, James O. Early, Roger J. S. Preston, Jennifer M. Hurley, David K. Finlay, Ingmar Schoen, F. Javier Sánchez-García, Kingston H. G. Mills, Annie M. Curtis
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Circadian rhythms are known to impact a range of biological processes including in the immune system. Here the authors show how circadian rhythms modulate the T cell response to vaccination via regulation of dendritic cell metabolism.
Externí odkaz:
https://doaj.org/article/4caf147bafa74b10bfcfd8fe7b6234a5
Autor:
Tristram A. J. Ryan, Alexander Hooftman, Aisling M. Rehill, Matt D. Johansen, Eóin C. O’ Brien, Juliana E. Toller-Kawahisa, Mieszko M. Wilk, Emily A. Day, Hauke J. Weiss, Pourya Sarvari, Emilio G. Vozza, Fabian Schramm, Christian G. Peace, Alessia Zotta, Stefan Miemczyk, Christina Nalkurthi, Nicole G. Hansbro, Gavin McManus, Laura O’Doherty, Siobhan Gargan, Aideen Long, Jean Dunne, Clíona Ní Cheallaigh, Niall Conlon, Michael Carty, Padraic G. Fallon, Kingston H. G. Mills, Emma M. Creagh, James S. O’ Donnell, Paul J. Hertzog, Philip M. Hansbro, Rachel M. McLoughlin, Małgorzata Wygrecka, Roger J. S. Preston, Zbigniew Zasłona, Luke A. J. O’Neill
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/3b72cd72017f45ae91810eb4f3826d16
Autor:
Zbigniew Zasłona, Ewelina Flis, Mieszko M. Wilk, Richard G. Carroll, Eva M. Palsson-McDermott, Mark M. Hughes, Ciana Diskin, Kathy Banahan, Dylan G. Ryan, Alexander Hooftman, Alicja Misiak, Jay Kearney, Gunter Lochnit, Wilhelm Bertrams, Timm Greulich, Bernd Schmeck, Oliver J. McElvaney, Kingston H. G. Mills, Ed C. Lavelle, Małgorzata Wygrecka, Emma M. Creagh, Luke A. J. O’Neill
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Caspase 11 activation involves transcriptional upregulation and proteolytic cleavage. Here the authors show that prostaglandin E2 prevents caspase-11-mediated pyroptosis, blocking caspase-11 mRNA and protein upregulation in macrophages and in vivo, a
Externí odkaz:
https://doaj.org/article/f9f58905287b4fe39d8a26ba82a9f274
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The burgeoning field of innate immune training, also called trained immunity, has given immunologists new insights into the role of innate responses in protection against infection and in modulating inflammation. Moreover, it has led to a paradigm sh
Externí odkaz:
https://doaj.org/article/79faa6f0729148bb9a3bcd3eea50b45e
Autor:
Mieszko M. Wilk, Lisa Borkner, Alicja Misiak, Lucy Curham, Aideen C. Allen, Kingston H. G. Mills
Publikováno v:
Emerging Microbes and Infections, Vol 8, Iss 1, Pp 169-185 (2019)
ABSTRACTProtective immunity wanes rapidly after immunization of children with acellular pertussis (aP) vaccines and these vaccines do not prevent nasal colonization or transmission of Bordetella pertussis in baboons. In this study, we examined the ro
Externí odkaz:
https://doaj.org/article/eb82c501985e43288f8b359db511a1c3
Autor:
Caroline E. Sutton, Conor M. Finlay, Mathilde Raverdeau, James O. Early, Joseph DeCourcey, Zbigniew Zaslona, Luke A. J. O’Neill, Kingston H. G. Mills, Annie M. Curtis
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Circadian controls of immune responses by the molecular clock have been reported, but the underlying mechanisms are unclear. Here the authors show that the master circadian gene, Bmal1, is essential for modulating the homeostasis of myeloid cells to
Externí odkaz:
https://doaj.org/article/4eaabe1ffd9242d6a2d583bbb9b1dc73
Autor:
Ivan P. Nascimento, Dunia Rodriguez, Carina C. Santos, Eduardo P. Amaral, Henrique K. Rofatto, Ana P. Junqueira-Kipnis, Eduardo D. C. Gonçalves, Maria R. D’Império-Lima, Mario H. Hirata, Celio L. Silva, Nathalie Winter, Brigitte Gicquel, Kingston H. G. Mills, Mariagrazia Pizza, Rino Rappuoli, Luciana C. C. Leite
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract In order to develop an improved BCG vaccine against tuberculosis we have taken advantage of the adjuvant properties of a non-toxic derivative of Escherichia coli heat labile enterotoxin (LT), LTAK63. We have constructed rBCG strains expressi
Externí odkaz:
https://doaj.org/article/df9d3306cb574c71b46f4ee32a1a4202
Autor:
Shauna M. Quinn, Kyle Cunningham, Mathilde Raverdeau, Robert J. Walsh, Lucy Curham, Anna Malara, Kingston H. G. Mills
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Recent studies have suggested that the innate immune system can display characteristics of immunological memory and this has been called “innate immune memory” or “trained immunity.” Certain fungal products have been shown to induce epigeneti
Externí odkaz:
https://doaj.org/article/54554074f01a40b1b3aad8b2ec152b8e