Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Kingson Lin"'
Autor:
Kingson Lin, Susan E. Gueble, Ranjini K. Sundaram, Eric D. Huseman, Ranjit S. Bindra, Seth B. Herzon
Publikováno v:
Science
Approximately half of glioblastoma and more than two-thirds of grade II and III glioma tumors lack the DNA repair protein O 6 -methylguanine methyl transferase (MGMT). MGMT-deficient tumors respond initially to the DNA methylation agent temozolomide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea1ad10312c1794f87b4e8e72c86da1c
https://europepmc.org/articles/PMC9502022/
https://europepmc.org/articles/PMC9502022/
Autor:
Eric D. Huseman, Anna Lo, Olga Fedorova, Kingson Lin, Susan Gueble, Ranjini Sundaram, Anna M. Pyle, Ranjit S. Bindra, Seth Herzon
Publikováno v:
Cancer Research. 83:1568-1568
The DNA damage repair protein O6-methylguanine methyl transferase (MGMT) reverses O6-alkylguanine lesions via SN2 transfer of the alkyl lesion to an active site cysteine which restores DNA to its native state. MGMT is ubiquitously expressed in health
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98b5c0e4d43c92c63598186dff779af0
https://doi.org/10.1158/1538-7445.am2023-1568
https://doi.org/10.1158/1538-7445.am2023-1568
Publikováno v:
ACS Catalysis
The chemoselective functionalization of polyfunctional aryl linchpins is crucial for rapid diversification. Although well-explored for Csp2 and Csp nucleophiles, the chemoselective introduction of Csp3 groups remains notoriously difficult and is virt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6060fe058f5f9a47007287e60784d9be
https://doi.org/10.1021/acscatal.7b01773
https://doi.org/10.1021/acscatal.7b01773
Publikováno v:
Organic Syntheses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78d968bb29720604e43147040016a7de
https://doi.org/10.15227/orgsyn.094.0016
https://doi.org/10.15227/orgsyn.094.0016