Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Kingsley King-Gee Tam"'
Autor:
Ketema Tafess, Timothy Ting-Leung Ng, Kingsley King-Gee Tam, Kenneth Siu-Sing Leung, Jake Siu-Lun Leung, Lam-Kwong Lee, Hiu Yin Lao, Chloe Toi-Mei Chan, Wing-Cheong Yam, Samson Sai Yin Wong, Terrence Chi-Kwong Lau, Gilman Kit-Hang Siu
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 4 (2024)
ABSTRACTThe incidence of isoniazid (INH) resistant Mycobacterium tuberculosis is increasing globally. This study aimed to identify the molecular mechanisms behind the development of INH resistance in M. tuberculosis strains collected from the same pa
Externí odkaz:
https://doaj.org/article/3ffa64bb1abf4ad388be8732347d351c
Autor:
Junhao Su, Wui Wang Lui, YanLam Lee, Zhenxian Zheng, Gilman Kit-Hang Siu, Timothy Ting-Leung Ng, Tong Zhang, Tommy Tsan-Yuk Lam, Hiu-Yin Lao, Wing-Cheong Yam, Kingsley King-Gee Tam, Kenneth Siu-Sing Leung, Tak-Wah Lam, Amy Wing-Sze Leung, Ruibang Luo
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Sensitive detection of Mycobacterium tuberculosis (TB) in small percentages in metagenomic samples is essential for microbial classification and drug resistance prediction. However, traditional methods, such as bacterial culture and microsco
Externí odkaz:
https://doaj.org/article/46b50dd1fbe14e5bbb82aa3778b2cfaf
Autor:
Kenneth Siu-Sing Leung, Kingsley King-Gee Tam, Timothy Ting-Leung Ng, Hiu-Yin Lao, Raymond Chiu-Man Shek, Oliver Chiu Kit Ma, Shi-Hui Yu, Jing-Xian Chen, Qi Han, Gilman Kit-Hang Siu, Wing-Cheong Yam
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
An in-house-developed target amplicon sequencing by next-generation sequencing technology (TB-NGS) enables simultaneous detection of resistance-related mutations in Mycobacterium tuberculosis (MTB) against 8 anti-tuberculosis drug classes. In this mu
Externí odkaz:
https://doaj.org/article/6efecdc1def946778444523c01ef14b7
Autor:
Kenneth Siu-Sing Leung, Timothy Ting-Leung Ng, Alan Ka-Lun Wu, Miranda Chong-Yee Yau, Hiu-Yin Lao, Ming-Pan Choi, Kingsley King-Gee Tam, Lam-Kwong Lee, Barry Kin-Chung Wong, Alex Yat Man Ho, Kam-Tong Yip, Kwok-Cheung Lung, Raymond Wai-To Liu, Eugene Yuk-Keung Tso, Wai-Shing Leung, Man-Chun Chan, Yuk-Yung Ng, Kit-Man Sin, Kitty Sau-Chun Fung, Sandy Ka-Yee Chau, Wing-Kin To, Tak-Lun Que, David Ho-Keung Shum, Shea Ping Yip, Wing Cheong Yam, Gilman Kit-Hang Siu
Publikováno v:
Emerging Infectious Diseases, Vol 27, Iss 1, Pp 196-204 (2021)
Initial cases of coronavirus disease in Hong Kong were imported from mainland China. A dramatic increase in case numbers was seen in February 2020. Most case-patients had no recent travel history, suggesting the presence of transmission chains in the
Externí odkaz:
https://doaj.org/article/9edf4aa73a2d47e994555d785faa68a7
Autor:
Gilman Kit-Hang Siu, Lam-Kwong Lee, Kenneth Siu-Sing Leung, Jake Siu-Lun Leung, Timothy Ting-Leung Ng, Chloe Toi-Mei Chan, Kingsley King-Gee Tam, Hiu-Yin Lao, Alan Ka-Lun Wu, Miranda Chong-Yee Yau, Yvette Wai-Man Lai, Kitty Sau-Chun Fung, Sandy Ka-Yee Chau, Barry Kin-Chung Wong, Wing-Kin To, Kristine Luk, Alex Yat-Man Ho, Tak-Lun Que, Kam-Tong Yip, Wing Cheong Yam, David Ho-Keung Shum, Shea Ping Yip
Publikováno v:
Emerging Microbes and Infections, Vol 9, Iss 1, Pp 2497-2500 (2020)
Externí odkaz:
https://doaj.org/article/9d17b7af308a4b93bee42e497c57cd1f
Autor:
Li Zhu, Annie Wing-Tung Lee, Kelvin Ka-Lok Wu, Peng Gao, Kingsley King-Gee Tam, Rahim Rajwani, Galata Chala Chaburte, Timothy Ting-Leung Ng, Chloe Toi-Mei Chan, Hiu Yin Lao, Wing Cheong Yam, Richard Yi-Tsun Kao, Gilman Kit Hang Siu
Publikováno v:
Antibiotics, Vol 11, Iss 3, p 369 (2022)
The emergence of multidrug-resistant strains and hyper-virulent strains of Mycobacterium tuberculosis are big therapeutic challenges for tuberculosis (TB) control. Repurposing bioactive small-molecule compounds has recently become a new therapeutic a
Externí odkaz:
https://doaj.org/article/423ff6ac35df4bd99875f98dd272bdc1
Autor:
Kenneth Siu-Sing Leung, Gilman Kit-Hang Siu, Kingsley King-Gee Tam, Sabrina Wai-Chi To, Rahim Rajwani, Pak-Leung Ho, Samson Sai-Yin Wong, Wei W. Zhao, Oliver Chiu-Kit Ma, Wing-Cheong Yam
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 7 (2017)
Background: Multidrug-resistant tuberculosis (MDR-TB) is posing a major threat to global TB control. In this study, we focused on two consecutive MDR-TB isolated from the same patient before and after the initiation of anti-TB treatment. To better un
Externí odkaz:
https://doaj.org/article/6ad7f07fc52c457f831ae561a09afcca
Autor:
Rahim Rajwani, Chala Galata, Annie Wing Tung Lee, Pui-Kin So, Kenneth Siu Sing Leung, Kingsley King Gee Tam, Sheeba Shehzad, Timothy Ting Leung Ng, Li Zhu, Hiu Yin Lao, Chloe Toi-Mei Chan, Jake Siu-Lun Leung, Lam-Kwong Lee, Kin Chung Wong, Wing Cheong Yam, Gilman Kit-Hang Siu
Publikováno v:
Virulence. 13:1088-1100
Clinical manifestations of tuberculosis range from asymptomatic infection to a life-threatening disease such as tuberculous meningitis (TBM). Recent studies showed that the spectrum of disease severity could be related to genetic diversity among clin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::591fd0765f37d2b29dce6387edabfb42
https://doi.org/10.1080/21505594.2022.2087304
https://doi.org/10.1080/21505594.2022.2087304
Autor:
Junhao Su, Wui Wang Lui, YanLam Lee, Zhenxian Zheng, Gilman Kit-Hang Siu, Timothy Ting-Leung Ng, Tong Zhang, Tommy Tsan-Yuk Lam, Hiu-Yin Lao, Wing-Cheong Yam, Kingsley King-Gee Tam, Kenneth Siu-Sing Leung, Tak-Wah Lam, Amy Wing-Sze Leung, Ruibang Luo
Sensitive detection ofMycobacterium Tuberculosis(TB) in small percentages in metagenomic samples is essential for microbial classification and drug resistance prediction, and assisting in diagnosis and treatment planning. However, traditional methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::80138fc09a275aa7ab9a261d7a04e32a
https://doi.org/10.1101/2022.12.17.520855
https://doi.org/10.1101/2022.12.17.520855
Autor:
Ketema Tafess, Kingsley King Gee Tam, Chalom Sayada, Hiu Yin Lao, Gobena Ameni, Timothy Ting-Leung Ng, Wing Cheong Yam, Gilman Kit Hang Siu, Oliver Chiu Kit Ma, Kenneth Siu Sing Leung, Corey Mang Kiu Chu, Belete Haile Nega, Lily Pui Ki Ho, Dimitri Gonzalez, Sarah Tsz Yan Tam, Rahim Rajwani
Publikováno v:
Clinical Chemistry. 66:809-820
Background The emergence of Mycobacterium tuberculosis with complex drug resistance profiles necessitates a rapid and comprehensive drug susceptibility test for guidance of patient treatment. We developed two targeted-sequencing workflows based on Il
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b4921e0e08ee87ad64e3774068a3e65
https://doi.org/10.1093/clinchem/hvaa092
https://doi.org/10.1093/clinchem/hvaa092