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pro vyhledávání: '"Kinghorn P"'
An open problem in artificial intelligence is how systems can flexibly learn discrete abstractions that are useful for solving inherently continuous problems. Previous work in computational neuroscience has considered this functional integration of d
Externí odkaz:
http://arxiv.org/abs/2409.01066
An open problem in artificial intelligence is how systems can flexibly learn discrete abstractions that are useful for solving inherently continuous problems. Previous work has demonstrated that a class of hybrid state-space model known as recurrent
Externí odkaz:
http://arxiv.org/abs/2408.10970
Active inference helps us simulate adaptive behavior and decision-making in biological and artificial agents. Building on our previous work exploring the relationship between active inference, well-being, resilience, and sustainability, we present a
Externí odkaz:
http://arxiv.org/abs/2406.07593
The ability to invent new tools has been identified as an important facet of our ability as a species to problem solve in dynamic and novel environments. While the use of tools by artificial agents presents a challenging task and has been widely iden
Externí odkaz:
http://arxiv.org/abs/2311.03893
Publikováno v:
Genetics Selection Evolution, Vol 56, Iss 1, Pp 1-9 (2024)
Abstract Background The objective of this study was to introduce a genome-wide association study (GWAS) in conjunction with segregation analysis on monogenic categorical traits. Genotype probabilities calculated from phenotypes, mode of inheritance a
Externí odkaz:
https://doaj.org/article/c49ff7ad9f3d4f65a9d9c1a36eb7a009
Autor:
Janet L. Oblinger, Jack Wang, Georgia D. Wetherell, Garima Agarwal, Tyler A. Wilson, Nicole R. Benson, Joelle M. Fenger, James R. Fuchs, A. Douglas Kinghorn, Long-Sheng Chang
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract Inhibition of translation initiation using eIF4A inhibitors like (−)-didesmethylrocaglamide [(−)-DDR] and (−)-rocaglamide [(−)-Roc] is a potential cancer treatment strategy as they simultaneously diminish multiple oncogenic drivers.
Externí odkaz:
https://doaj.org/article/9f51765470304068adff9d89398af258
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 3, Pp 102299- (2024)
Externí odkaz:
https://doaj.org/article/3ac9152dec7f4c4098b88f76b5bc0e47
Predictive Coding Networks (PCNs) aim to learn a generative model of the world. Given observations, this generative model can then be inverted to infer the causes of those observations. However, when training PCNs, a noticeable pathology is often obs
Externí odkaz:
http://arxiv.org/abs/2208.07114
Publikováno v:
Autophagy Reports, Vol 3, Iss 1 (2024)
Mutations in the GBA1 (glucosylceramidase beta 1) gene cause the most common lysosomal storage disorder, Gaucher disease (GD), characterized by the lysosomal accumulation of glucosylceramide and lysosomal dysfunction. Downstream of defects in lysosom
Externí odkaz:
https://doaj.org/article/f46664a91cfc481a9e24b29497b3b13b
Autor:
Stephen Winchester, Alex Castellarnau, Kashif Jabbar, Meera Nadir, Kapila Ranasinghe, Xavier Masramon, George R. Kinghorn, Isaac John, Jeremy R. A. Paull
Publikováno v:
Pharmaceutics, Vol 16, Iss 9, p 1173 (2024)
Background/Objectives: Dendrimer-based astodrimer sodium nasal spray was assessed for its ability to reduce SARS-CoV-2 load in outpatients with COVID-19, which remains a severe illness for vulnerable groups. Methods: This was a randomised, double-bli
Externí odkaz:
https://doaj.org/article/8328b88d31f24c06a1dcb7cc099e0bf0