Microglia Depletion Attenuates the Pro-Resolving Activity of the Formyl Peptide Receptor 2 Agonist AMS21 Related to Inhibition of Inflammasome NLRP3 Signalling Pathway: A Study of Organotypic Hippocampal Cultures

Autor: Kinga Tylek, Ewa Trojan, Monika Leśkiewicz, Imane Ghafir El Idrissi, Enza Lacivita, Marcello Leopoldo, Agnieszka Basta-Kaim

Publikováno v: Cells, Vol 12, Iss 21, p 2570 (2023)

Microglial cells have been demonstrated to be significant resident immune cells that maintain homeostasis under physiological conditions. However, prolonged or excessive microglial activation leads to disturbances in the resolution of inflammation (R

Externí odkaz: https://doaj.org/article/4f8a9ab872b44c05b7da50007e97f28f

Time-Dependent Protective and Pro-Resolving Effects of FPR2 Agonists on Lipopolysaccharide-Exposed Microglia Cells Involve Inhibition of NF-κB and MAPKs Pathways

Autor: Kinga Tylek, Ewa Trojan, Monika Leśkiewicz, Magdalena Regulska, Natalia Bryniarska, Katarzyna Curzytek, Enza Lacivita, Marcello Leopoldo, Agnieszka Basta-Kaim

Publikováno v: Cells, Vol 10, Iss 9, p 2373 (2021)

Prolonged or excessive microglial activation may lead to disturbances in the resolution of inflammation (RoI). The importance of specialized pro-resolving lipid mediators (SPMs) in RoI has been highlighted. Among them, lipoxins (LXA4) and aspirin-tri

Externí odkaz: https://doaj.org/article/26d2884d296f4d0fbb1fe7a110ee7d32

Time-Dependent Protective and Pro-Resolving Effects of FPR2 Agonists on Lipopolysaccharide-Exposed Microglia Cells Involve Inhibition of NF-κB and MAPKs Pathways

Autor: Monika Leśkiewicz, Kinga Tylek, Magdalena Regulska, Agnieszka Basta-Kaim, Natalia Bryniarska, Katarzyna Curzytek, Enza Lacivita, Marcello Leopoldo, Ewa Trojan

Publikováno v: Cells
Volume 10
Issue 9
Cells, Vol 10, Iss 2373, p 2373 (2021)

Prolonged or excessive microglial activation may lead to disturbances in the resolution of inflammation (RoI). The importance of specialized pro-resolving lipid mediators (SPMs) in RoI has been highlighted. Among them, lipoxins (LXA4) and aspirin-tri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4359b5eb2a5efb7f7037c2728f133388
https://pubmed.ncbi.nlm.nih.gov/34572022

The N-Formyl Peptide Receptor 2 (FPR2) Agonist MR-39 Exhibits Anti-Inflammatory Activity in LPS-Stimulated Organotypic Hippocampal Cultures

Autor: Marcello Leopoldo, Lars-Ove Brandenburg, Monika Leśkiewicz, Enza Lacivita, Agnieszka Basta-Kaim, Ewa Trojan, Kinga Tylek, Władysław Lasoń

Publikováno v: Cells : open access journal 10(6), 1524 (2021). doi:10.3390/cells10061524 special issue: "Special Issue "Studies around Neuroinflammation-Series 2" / Special Issue Editor: Dr. Lars Ove Brandenburg, Guest Editor"
Cells
Cells, Vol 10, Iss 1524, p 1524 (2021)
Volume 10
Issue 6

Accumulating evidence indicates a pivotal role for chronic inflammatory processes in the pathogenesis of neurodegenerative and psychiatric disorders. G protein-coupled formyl peptide receptor 2 (FPR2) mediates pro-inflammatory or anti-/pro-resolving

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4f28c341486761434f299a7ec610d09