Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Kinga Szigeti"'
Autor:
Kinga Szigeti, Ivanna Ihnatovych, Emily Notari, Ryu P. Dorn, Ivan Maly, Muye He, Barbara Birkaya, Shreyas Prasad, Robin Schwartz Byrne, Dinesh C. Indurthi, Erik Nimmer, Yuna Heo, Kolos Retfalvi, Lee Chaves, Norbert Sule, Wilma A. Hofmann, Anthony Auerbach, Gregory Wilding, Yongho Bae, Jessica Reynolds
Publikováno v:
EBioMedicine, Vol 103, Iss , Pp 105093- (2024)
Summary: Background: Human restricted genes contribute to human specific traits in the immune system. CHRFAM7A, a uniquely human fusion gene, is a negative regulator of the α7 nicotinic acetylcholine receptor (α7 nAChR), the highest Ca2+ conductor
Externí odkaz:
https://doaj.org/article/253d4e81484540ca907db9935ccfbe93
Autor:
Dejan Jakimovski, Ryu P. Dorn, Megan Del Regno, Alexander Bartnik, Niels Bergsland, Murali Ramanathan, Michael G. Dwyer, Ralph H. B. Benedict, Robert Zivadinov, Kinga Szigeti
Publikováno v:
Frontiers in Neuroscience, Vol 18 (2024)
IntroductionCHRFAM7A, a uniquely human fusion gene, has been associated with neuropsychiatric disorders including Alzheimer’s disease, schizophrenia, anxiety, and attention deficit disorder. Understanding the physiological function of CHRFAM7A in t
Externí odkaz:
https://doaj.org/article/493eeae30ec648188dbf9fbac2508561
Autor:
Kinga Szigeti, Ivanna Ihnatovych, Nicolás Rosas, Ryu P. Dorn, Emily Notari, Eduardo Cortes Gomez, Muye He, Ivan Maly, Shreyas Prasad, Erik Nimmer, Yuna Heo, Beata Fuchsova, David A. Bennett, Wilma A. Hofmann, Arnd Pralle, Yongho Bae, Jianmin Wang
Publikováno v:
EBioMedicine, Vol 95, Iss , Pp 104725- (2023)
Summary: Background: While advancements in imaging techniques have led to major strides in deciphering the human brain, successful interventions are elusive and represent some of the most persistent translational gaps in medicine. Human restricted CH
Externí odkaz:
https://doaj.org/article/031ba2cc9b5342909306c7402cd8c79a
Autor:
John Gillies, Lauren Olson, Riam Almukhtar, Andy Strohmeier, Kinga Szigeti, David Schretlen, Renee Cadzow, Ralph Benedict
Publikováno v:
Journal of Clinical and Translational Science, Vol 7 (2023)
Externí odkaz:
https://doaj.org/article/3845d0fbffb7405b934debc59b3e6d85
Autor:
Mallory Ziegler, Alexandrea Adams, Jingtao Zhu, Allison Case, Natalie Argueta, Ashley Regling, Gregory Wilding, Kinga Szigeti
Publikováno v:
Journal of Clinical and Translational Science, Vol 7, Pp 54-55 (2023)
OBJECTIVES/GOALS: Minoritized populations experience a large burden of Alzheimer’s Disease; interventions are often delayed and underrepresented communities’ participation in clinical trial research is low. Lack of information has been proposed a
Externí odkaz:
https://doaj.org/article/16b71c962502449dbfd4ece48ee547f8
Autor:
Andy Strohmeier, Lauren Olson, Riam Almukhtar, Kinga Szigeti, David Schretlen, Renee Cadzow, Ralph Benedict
Publikováno v:
Journal of Clinical and Translational Science, Vol 7, Pp 64-65 (2023)
OBJECTIVES/GOALS: Language is the main barrier to equitable access of neuropsychological resources. In our preliminary study, using an Arabic translation of the Global Neuropsychological Assessment (GNA), we assessed 27 Arabic-speaking participants a
Externí odkaz:
https://doaj.org/article/1a2a097cfb1e46b9bb2f71d56a86784d
Autor:
Kinga Szigeti, Ivanna Ihnatovych, Barbara Birkaya, Ziqiang Chen, Aya Ouf, Dinesh C. Indurthi, Jonathan E. Bard, Julien Kann, Alexandrea Adams, Lee Chaves, Norbert Sule, Joan S. Reisch, Valory Pavlik, Ralph H.B. Benedict, Anthony Auerbach, Gregory Wilding
Publikováno v:
EBioMedicine, Vol 59, Iss , Pp 102892- (2020)
Background: Cholinergic neuronal loss is one of the hallmarks of AD related neurodegeneration; however, preclinical promise of α7 nAChR drugs failed to translate into humans. CHRFAM7A, a uniquely human fusion gene, is a negative regulator of α7 nAC
Externí odkaz:
https://doaj.org/article/6f7ea999104a48eb91f60c5ad0633972
Autor:
Dejan Jakimovski, Bianca Weinstock-Guttman, Shumita Roy, Michael Jaworski, Laura Hancock, Alissa Nizinski, Pavitra Srinivasan, Tom A. Fuchs, Kinga Szigeti, Robert Zivadinov, Ralph H. B. Benedict
Publikováno v:
Frontiers in Aging Neuroscience, Vol 11 (2019)
BackgroundIncreasingly favorable mortality prognosis in multiple sclerosis (MS) raises questions regarding MS-specific cognitive aging and the presence of comorbidities such as Alzheimer’s disease (AD).ObjectiveTo assess elderly with MS (EwMS) and
Externí odkaz:
https://doaj.org/article/9314eb8ff2064fda96b0bfd5c9c95838
Publikováno v:
Stem Cells International, Vol 2018 (2018)
In vitro differentiation of human pluripotent stem cell into relevant cell types is a desirable model system that has the human biological context, is a renewable source, and is scalable. GABA interneurons and basal forebrain cholinergic neurons, der
Externí odkaz:
https://doaj.org/article/9cf3750eb60c4c7aba7b9285a66f07f2
Autor:
Anthony Antonellis, Megan Y Dennis, Grzegorz Burzynski, Jimmy Huynh, Valerie Maduro, Chani J Hodonsky, Mehrdad Khajavi, Kinga Szigeti, Sandeep Mukkamala, Seneca L Bessling, William J Pavan, Andrew S McCallion, James R Lupski, Eric D Green, NISC Comparative Sequencing Program
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e14346 (2010)
Myelin protein zero (MPZ) is a critical structural component of myelin in the peripheral nervous system. The MPZ gene is regulated, in part, by the transcription factors SOX10 and EGR2. Mutations in MPZ, SOX10, and EGR2 have been implicated in demyel
Externí odkaz:
https://doaj.org/article/0911ef5b476045b4ab4871b2f20a088a