Výsledky vyhledávání - "Kinga Szekely Szucs"

P21Cip1 Is a Critical Mediator of the Cytotoxic Action of Thymidylate Synthase Inhibitors in Colorectal Carcinoma Cells

Autor: James I. Geller, Belinda T. Doyle, István Peták, Kinga Szekely-Szucs, Janet A. Houghton

Publikováno v: Cancer Research. 64:6296-6303

We have demonstrated previously that interferon (IFN)-γ sensitizes human colon carcinoma cell lines to the cytotoxic effects of 5-fluorouracil combined with leucovorin and to the thymidylate synthase inhibitor, ZD9331, dependent on thymineless stres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3416796b5c8919423a7d052d5ec3a35d
https://doi.org/10.1158/0008-5472.can-04-0863

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A caspase-8-independent component in TRAIL/Apo-2L-induced cell death in human rhabdomyosarcoma cells

Autor: M. Anozie, Kinga Szekely Szucs, Darren C. Phillips, David M. Tillman, Leslie Douglas, István Peták, Janet A. Houghton, Reka Vernes, Kamel Izeradjene

Publikováno v: Cell Death & Differentiation. 10:729-739

Tumor necrosis factor related apoptosis inducing ligand (TRAIL) belongs to the Tumor necrosis factor (TNF) family of death-inducing ligands, and signaling downstream of TRAIL ligation to its receptor(s) remains to be fully elucidated. Components of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aead2c0170923411916260d52202bd6c
https://doi.org/10.1038/sj.cdd.4401232

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Cyclooxygenase-2 Inhibition Sensitizes Human Colon Carcinoma Cells to TRAIL-Induced Apoptosis through Clustering of DR5 and Concentrating Death-Inducing Signaling Complex Components into Ceramide-Enriched Caveolae

Autor: Janet A. Houghton, Darren C. Phillips, Fabienne Desmots, Lynda Elghazi, Kinga Szekely-Szucs, Sophie Martin

Publikováno v: Cancer Research
Cancer Research, 2005, 65 (24), pp.11447-11458. ⟨10.1158/0008-5472.CAN-05-1494⟩
Cancer Research, American Association for Cancer Research, 2005, 65 (24), pp.11447-11458. ⟨10.1158/0008-5472.CAN-05-1494⟩

Cyclooxygenase-2 (COX-2) is up-regulated in human colon carcinomas, and its inhibition is associated with a reduction in tumorigenesis and a promotion of apoptosis. However, the mechanisms responsible for the antitumor effects of COX-2 inhibitors and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0258b9f1302a5cb551b1bdee03885e8d
https://hal.science/hal-02463124

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Interferon-gamma-induced sensitization of colon carcinomas to ZD9331 targets caspases, downstream of Fas, independent of mitochondrial signaling and the inhibitor of apoptosis survivin

Autor: James, Geller, Istvan, Petak, Kinga Szekely, Szucs, Katalin, Nagy, David M, Tillman, Janet A, Houghton

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 9(17)

We have demonstrated previously a Fas-dependent component in thymineless death of human colon carcinoma cells. Importantly, the cytotoxic effects of thymidine deprivation induced by 5-fluorouracil (FUra) combined with leucovorin (LV) was enhanced by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9049df8a883b4f05d1a409744d7aee9a
https://pubmed.ncbi.nlm.nih.gov/14695155

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Rottlerin sensitizes colon carcinoma cells to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis via uncoupling of the mitochondria independent of protein kinase C

Autor: David M, Tillman, Kamel, Izeradjene, Kinga Szekely, Szucs, Leslie, Douglas, Janet A, Houghton

Publikováno v: Cancer research. 63(16)

Signaling pathways involved in survival responses may attenuate the apoptotic response to the cytotoxic tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in human colon carcinomas. In six lines examined, three were sensitive (GC(3)/c1,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::29c522b1754d679468ffcb82eda821da
https://pubmed.ncbi.nlm.nih.gov/12941843

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