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Impact of copy number variant and single nucleotide polymorphism of the programmed death-ligand 1 gene, programmed death-ligand 1 protein expression and therapy regimens on overall survival in a large group of Caucasian patients with non-small cell lung carcinoma

Autor: Kinga Lew, Paweł Krawczyk, Aleksandra Szczesna, Andrzej Sieracki, Kinga Krukowska, Tomasz Kucharczyk, Bożena Jarosz, Rodryg Ramlau, Robert Kieszko, Andrzej Kazarnowicz, Jan Siwiec, Justyna Błach, Daria Świniuch, Piotr Serwatowski, Tomasz Grodzki, Sebastian Fidler, Iwona Paśnik, Janusz Milanowski, Izabela Chmielewska, Katarzyna Stencel, Aleksandra Bożyk, Michał Gil, Jarosław Buczkowski, Katarzyna Reszka, Tomasz Kubiatowski, Juliusz Pankowski, Anna Grenda

Publikováno v: Oncology Letters

Anti-programmed death-1 or anti-programmed death-ligand 1 (PD-L1) blockade may be ineffective in some patients with non-small cell lung cancer (NSCLC) with high percentage of tumor cells with PD-L1 expression. In addition, immunotherapy may provide g

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