Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Kinga K. Hosszu"'
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Genetic deficiency in C1q is a strong susceptibility factor for systemic lupus erythematosus (SLE). There are two major hypotheses that potentially explain the role of C1q in SLE. The first postulates that C1q deficiency abrogates apoptotic cell clea
Externí odkaz:
https://doaj.org/article/5a22f3eac8e54fb38584e634dcea26c7
Publikováno v:
Frontiers in Pediatrics, Vol 8 (2020)
Hematopoietic cell transplantation (HCT) is often a last resort, but potentially curative treatment option for children suffering from hematological malignancies and a variety of non-malignant disorders, such as bone marrow failure, inborn metabolic
Externí odkaz:
https://doaj.org/article/0f0d471dd4394bba828185db951e6400
Autor:
Jaap Jan Boelens, Renier J Brentjens, Young Park, Ruby Freeman, Sanam Shahid, Abdul G Khan, Serena C Mathew, Sydney Souness, Erin R Burns, Jasmine S Um, Kento Tanaka, Winson Cai, Sarah Yoo, Andrew Dunbar, Devin McAvoy, Kinga K Hosszu, Ross L Levine, Ivo C Lorenz, Anthony F Daniyan
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 5 (2024)
Background CD33 is a tractable target in acute myeloid leukemia (AML) for chimeric antigen receptor (CAR) T cell therapy, but clinical success is lacking.Methods We developed 3P14HLh28Z, a novel CD33-directed CD28/CD3Z-based CAR T cell derived from a
Externí odkaz:
https://doaj.org/article/b42d94a937d841e2987bd9a5c7486879
Autor:
Hana Andrlová, Oriana Miltiadous, Anastasia I. Kousa, Anqi Dai, Susan DeWolf, Sara Violante, Hee-Yon Park, Sudha Janaki-Raman, Rui Gardner, Sary El Daker, John Slingerland, Paul Giardina, Annelie Clurman, Antonio L. C. Gomes, Chi Nguyen, Marina Burgos da Silva, Gabriel K. Armijo, Nicole Lee, Roberta Zappasodi, Ronan Chaligne, Ignas Masilionis, Emily Fontana, Doris Ponce, Christina Cho, Amy Bush, Lauren Hill, Nelson Chao, Anthony D. Sung, Sergio Giralt, Esther H. Vidal, Kinga K. Hosszu, Sean M. Devlin, Jonathan U. Peled, Justin R. Cross, Miguel-Angel Perales, Dale I. Godfrey, Marcel R. M. van den Brink, Kate A. Markey
Publikováno v:
Sci Transl Med
Microbial diversity is associated with improved outcomes in recipients of allogeneic hematopoietic cell transplantation (allo-HCT), but the mechanism underlying this observation is unclear. In a cohort of 174 patients who underwent allo-HCT, we demon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27ba4e8238db708b8a855188874d6859
https://doi.org/10.1126/scitranslmed.abj2829
https://doi.org/10.1126/scitranslmed.abj2829
Publikováno v:
Frontiers in Immunology, Vol 5 (2014)
The ability of circulating blood monocytes to express C1q receptors (cC1qR and gC1qR)synthesize and secrete the classical pathway proteins C1q, C1r and C1s and their regulator, C1-INH is very well established. What is intriguing however is that, in a
Externí odkaz:
https://doaj.org/article/60b5eb81bc3a44ddb172dd4890a31b46
Publikováno v:
Frontiers in Pediatrics, Vol 8 (2020)
Frontiers in Pediatrics
Frontiers in Pediatrics
Hematopoietic cell transplantation (HCT) is often a last resort, but potentially curative treatment option for children suffering from hematological malignancies and a variety of non-malignant disorders, such as bone marrow failure, inborn metabolic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3e70c24c3ab8afccbb4b0229907f65f
https://www.frontiersin.org/article/10.3389/fped.2020.00454/full
https://www.frontiersin.org/article/10.3389/fped.2020.00454/full
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 11 (2020)
Frontiers in Immunology, Vol 11 (2020)
Genetic deficiency in C1q is a strong susceptibility factor for systemic lupus erythematosus (SLE). There are two major hypotheses that potentially explain the role of C1q in SLE. The first postulates that C1q deficiency abrogates apoptotic cell clea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bcb18efa554ff0dcf34009539152c49
https://pubmed.ncbi.nlm.nih.gov/33117397
https://pubmed.ncbi.nlm.nih.gov/33117397
Autor:
David J. Chung, Neha Korde, Jonathan Landa, Devanjan S. Sikder, Carlyn Tan, Malin Hultcrantz, Isabelle Riviere, Eric L. Smith, Ahmet Dogan, Heather Landau, Peter Kane, Claudia Diamonte, Renier J. Brentjens, Patrick Grant, Diana Frias, Urvi A Shah, Sean M. Devlin, Ola Landgren, Terence J. Purdon, Sham Mailankody, Vladimir P. Bermudez, Brigitte Senechal, Kinga K. Hosszu, Michael Scordo, Hani Hassoun, Gunjan L. Shah, Xiuyan Wang, Lisa Fitzgerald, Alexander M. Lesokhin, Mikhail Roshal, Justina Morgan, Sergio Giralt, Jae H. Park
Publikováno v:
Blood. 138:827-827
Background: BCMA targeted CAR T cell therapy has shown promising results in patients with relapsed/refractory multiple myeloma (RRMM), but relapses are common. Additional treatment options with novel therapeutic targets or mechanisms of action are ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f1ec7bdd5ace7386358c663604cb20d8
https://doi.org/10.1182/blood-2021-153204
https://doi.org/10.1182/blood-2021-153204
Publikováno v:
Molecular Immunology. 84:26-33
Most of the complement proteins in circulation are, by and large, synthesized in the liver. However data accumulated over the past several decades provide incontrovertible evidence that some if not most of the individual complement proteins are also
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70fc89642ae4284fc8328876ee821472
https://doi.org/10.1016/j.molimm.2016.11.003
https://doi.org/10.1016/j.molimm.2016.11.003
Autor:
Ellinor I.B. Peerschke, Mahalakshmi Ramadass, Adarsh Kadoor, Berhane Ghebrehiwet, Nithin Tumma, Lina Pednekar, Yan Ji, Richard R. Kew, Uday Kishore, Kinga K. Hosszu, Alisa Valentino, Christopher Valentino
Publikováno v:
Molecular Immunology. 74:18-26
A substantial body of evidence accumulated over the past 20 years supports the concept that gC1qR is a major pathogen-associated pattern recognition receptor (PRR). This conclusion is based on the fact that, a wide range of bacterial and viral ligand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20008dba082fcac7db609a3a7142d5c8
https://doi.org/10.1016/j.molimm.2016.03.016
https://doi.org/10.1016/j.molimm.2016.03.016