Zobrazeno 1 - 10
of 153
pro vyhledávání: '"Kinga, Sałat"'
Publikováno v:
Molecules, Vol 29, Iss 18, p 4354 (2024)
Alzheimer’s disease (AD) is a neurodegenerative disorder, characterized by the formation of amyloid β and tau protein aggregates in the brain, neuroinflammation, impaired cholinergic neurotransmission, and oxidative stress, resulting in the gradua
Externí odkaz:
https://doaj.org/article/c236341de8064b2ab1ed28f95ca7edd4
Autor:
Damijan Knez, Daniel Diez-Iriepa, Mourad Chioua, Andrea Gottinger, Milica Denic, Fabien Chantegreil, Florian Nachon, Xavier Brazzolotto, Anna Skrzypczak-Wiercioch, Anže Meden, Anja Pišlar, Janko Kos, Simon Žakelj, Jure Stojan, Kinga Sałat, Julia Serrano, Ana Patricia Fernández, Aitana Sánchez-García, Ricardo Martínez-Murillo, Claudia Binda, Francisco López-Muñoz, Stanislav Gobec, José Marco-Contelles
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 5, Pp 2152-2175 (2023)
We describe the development of quinolylnitrones (QNs) as multifunctional ligands inhibiting cholinesterases (ChEs: acetylcholinesterase and butyrylcholinesterase–hBChE) and monoamine oxidases (hMAO-A/B) for the therapy of neurodegenerative diseases
Externí odkaz:
https://doaj.org/article/7f16c8ed45a64b12942b299889a26612
Publikováno v:
Molecules, Vol 28, Iss 23, p 7862 (2023)
Background: Neuropathic pain is drug-resistant to available analgesics and therefore novel treatment options for this debilitating clinical condition are urgently needed. Recently, two drug candidates, namely mirogabalin and cebranopadol have become
Externí odkaz:
https://doaj.org/article/4356fbe466b7478abf67e1626055386e
Autor:
Małgorzata Frankowska, Karolina Wydra, Agata Suder, Magdalena Zaniewska, Dawid Gawliński, Joanna Miszkiel, Anna Furgała-Wojas, Kinga Sałat, Małgorzata Filip, Christa E. Müller, Katarzyna Kieć-Kononowicz, Magdalena Kotańska
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 10, p 9046 (2023)
The lack of selective pharmacological tools has limited the full unraveling of G protein-coupled receptor 18 (GPR18) functions. The present study was aimed at discovering the activities of three novel preferential or selective GPR18 ligands, one agon
Externí odkaz:
https://doaj.org/article/4d952f28f5f14686af719815d48449b3
Autor:
Anna Skrzypczak-Wiercioch, Kinga Sałat
Publikováno v:
Molecules, Vol 27, Iss 17, p 5481 (2022)
Despite advances in antimicrobial and anti-inflammatory therapies, inflammation and its consequences still remain a significant problem in medicine. Acute inflammatory responses are responsible for directly life-threating conditions such as septic sh
Externí odkaz:
https://doaj.org/article/981cd78d44444685a612191952aee7a5
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 111, Iss , Pp 882-890 (2019)
Background and purpose: Chemotherapy-induced peripheral neuropathy (CIPN) is a pharmacoresistant neurological complication induced by some antitumor drugs. This study aimed to assess antiallodynic properties of aripiprazole and ceftriaxone used alone
Externí odkaz:
https://doaj.org/article/4ca2dc8dfa754546b81bea59742a1bd2
Autor:
Gniewomir Latacz, Kinga Sałat, Anna Furgała-Wojas, Adrian Martyniak, Agnieszka Olejarz-Maciej, Ewelina Honkisz-Orzechowska, Ewa Szymańska
Publikováno v:
Molecules, Vol 27, Iss 3, p 875 (2022)
Trying to meet the multitarget-directed ligands strategy, a series of previously described aryl-substituted phenylalanine derivatives, reported as competitive antagonists of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, were
Externí odkaz:
https://doaj.org/article/30c4052d21b04e6595507df4b292cee4
Autor:
Magdalena Kowalska, Łukasz Fijałkowski, Monika Kubacka, Kinga Sałat, Grzegorz Grześk, Jacek Nowaczyk, Alicja Nowaczyk
Publikováno v:
Molecules, Vol 26, Iss 12, p 3522 (2021)
Tiagabine is an antiepileptic drug used for the treatment of partial seizures in humans. Recently, this drug has been found useful in several non-epileptic conditions, including anxiety, chronic pain and sleep disorders. Since tachycardia—an impair
Externí odkaz:
https://doaj.org/article/fb506d4cf75f435fb676ac94ae02bc74
Publikováno v:
Molecules, Vol 26, Iss 12, p 3577 (2021)
The antitumor drug, oxaliplatin, induces neuropathic pain, which is resistant to available analgesics, and novel mechanism-based therapies are being evaluated for this debilitating condition. Since activated microglia, impaired serotonergic and norad
Externí odkaz:
https://doaj.org/article/ef96d6b8b5c84eb7aefcf68abaced5d2
Autor:
Kinga Sałat, Anna Furgała-Wojas
Publikováno v:
Molecules, Vol 26, Iss 8, p 2398 (2021)
Fibromyalgia is a disease characterized by lowered pain threshold, mood disorders, and decreased muscular strength. It results from a complex dysfunction of the nervous system and due to unknown etiology, its diagnosis, treatment, and prevention are
Externí odkaz:
https://doaj.org/article/4f4a3473e38a42dcbcd6118ac0602acb