Zobrazeno 1 - 10
of 104
pro vyhledávání: '"King-Ho Cheung"'
Autor:
Ashok Iyaswamy, Abhimanyu Thakur, Xin-Jie Guan, Senthilkumar Krishnamoorthi, Tsz Yan Fung, Kejia Lu, Isha Gaurav, Zhijun Yang, Cheng-Fu Su, Kwok-Fai Lau, Kui Zhang, Roy Chun-Laam Ng, Qizhou Lian, King-Ho Cheung, Keqiang Ye, Huanhuan Joyce Chen, Min Li
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-14 (2023)
Abstract Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by the predominant impairment of neurons in the hippocampus and the formation of amyloid plaques, hyperphosphorylated tau protein, and neurofibrillary tangles in the br
Externí odkaz:
https://doaj.org/article/6b764bb85ea2452a913aa80974bdc655
Autor:
Alexis Shiying Huang, Benjamin Chun-Kit Tong, Harry Chun-Hin Hung, Aston Jiaxi Wu, Olivia Ka-Yi Ho, Anna Hau-Yee Kong, Maggie Ming-Ki Leung, Jingxuan Bai, Xiuqiong Fu, Zhiling Yu, Min Li, Ting Fan Leung, Judith Choi-Wo Mak, George Pak-Heng Leung, King-Ho Cheung
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 164, Iss , Pp 114935- (2023)
Asthma is a chronic inflammatory disease characterized by airway hypersensitivity and remodeling. The current treatments provide only short-term benefits and may have undesirable side effects; thus, alternative or supplementary therapy is needed. Bec
Externí odkaz:
https://doaj.org/article/1d41626c403a46bab74ee0dfc62cae41
Autor:
Benjamin Chun-Kit Tong, Alexis Shiying Huang, Aston Jiaxi Wu, Ashok Iyaswamy, Olivia Ka-Yi Ho, Anna Hau-Yee Kong, Sravan Gopalkrishnashetty Sreenivasmurthy, Zhou Zhu, Chengfu Su, Jia Liu, Juxian Song, Min Li, King-Ho Cheung
Publikováno v:
Journal of Biomedical Science, Vol 29, Iss 1, Pp 1-19 (2022)
Abstract Background Tauopathies are neurodegenerative diseases that are associated with the pathological accumulation of tau-containing tangles in the brain. Tauopathy can impair cognitive and motor functions and has been observed in Alzheimer’s di
Externí odkaz:
https://doaj.org/article/6edbad36a8ed4f1cb6143dc98ca27f33
Autor:
Sravan Gopalkrishnashetty Sreenivasmurthy, Ashok Iyaswamy, Senthilkumar Krishnamoorthi, Rambabu N. Reddi, Ananth Kumar Kammala, Karthick Vasudevan, Sanjib Senapati, Zhou Zhu, Cheng-Fu Su, Jia Liu, Xin-Jie Guan, Ka-Kit Chua, King-Ho Cheung, Hubiao Chen, Hong-Jie Zhang, Yuan Zhang, Ju-Xian Song, Siva Sundara Kumar Durairajan, Min Li
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Emerging evidence from Alzheimer’s disease (AD) patients suggests that reducing tau pathology can restore cognitive and memory loss. To reduce tau pathology, it is critical to find brain-permeable tau-degrading small molecules that are safe and eff
Externí odkaz:
https://doaj.org/article/ad4864ffb5f248789897756ed41a5785
Autor:
Anna Hau-Yee Kong, Aston Jiaxi Wu, Olivia Ka-Yi Ho, Maggie Ming-Ki Leung, Alexis Shiying Huang, Yuanyuan Yu, Ge Zhang, Aiping Lyu, Min Li, King-Ho Cheung
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 14, p 11780 (2023)
Neuroinflammation is the precursor for several neurodegenerative diseases (NDDs), such as Alzheimer’s disease (AD), Parkinson’s disease (PD), and multiple sclerosis (MS). Targeting neuroinflammation has emerged as a promising strategy to address
Externí odkaz:
https://doaj.org/article/679e41956e4b4ba78081b0c857f2904f
Autor:
Ashok Iyaswamy, Xueli Wang, Senthilkumar Krishnamoorthi, Venkatapathy Kaliamoorthy, Sravan G. Sreenivasmurthy, Siva Sundara Kumar Durairajan, Ju-Xian Song, Benjamin Chun-kit Tong, Zhou Zhu, Cheng-Fu Su, Jia Liu, King-Ho Cheung, Jia-Hong Lu, Jie-Qiong Tan, Hung Wing Li, Man Shing Wong, Min Li
Publikováno v:
Redox Biology, Vol 51, Iss , Pp 102280- (2022)
Accumulation of amyloid-β (Aβ) oligomers and phosphorylated Tau aggregates are crucial pathological events or factors that cause progressive neuronal loss, and cognitive impairments in Alzheimer's disease (AD). Current medications for AD have faile
Externí odkaz:
https://doaj.org/article/17aea313beb2415fa02ef3251a86296c
Autor:
Xinjie Guan, Ashok Iyaswamy, Sravan Gopalkrishnashetty Sreenivasmurthy, Chengfu Su, Zhou Zhu, Jia Liu, Yuxuan Kan, King-Ho Cheung, Jiahong Lu, Jieqiong Tan, Min Li
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 7, p 3609 (2022)
Eukaryotic cells possess a plethora of regulatory mechanisms to maintain homeostasis and ensure proper biochemical functionality. Autophagy, a central, conserved self-consuming process of the cell, ensures the timely degradation of damaged cellular c
Externí odkaz:
https://doaj.org/article/b87c64edb5e04a949c4751be10f1a6a8
Autor:
Chuanbin Yang, Zhou Zhu, Benjamin Chun-Kit Tong, Ashok Iyaswamy, Wen-Jian Xie, Yu Zhu, Sravan Gopalkrishnashetty Sreenivasmurthy, Krishnamoorthi Senthilkumar, King-Ho Cheung, Ju-Xian Song, Hong-Jie Zhang, Min Li
Publikováno v:
Redox Biology, Vol 32, Iss , Pp - (2020)
TFEB (transcription factor EB) and TFE3 (transcription factor E3) are “master regulators” of autophagy and lysosomal biogenesis. The stress response p38 mitogen-activated protein (MAP) kinases affect multiple intracellular responses including inf
Externí odkaz:
https://doaj.org/article/c04ef8a7b81a484cbf678263a4064a0f
Autor:
Long Yang, Wenwen Gu, King-Ho Cheung, Lan Yan, Benjamin Chun-Kit Tong, Yuanying Jiang, Jun Yang
Publikováno v:
BMC Biology, Vol 16, Iss 1, Pp 1-16 (2018)
Abstract Background Candida albicans (C. albicans) invasion triggers antifungal innate immunity, and the elevation of cytoplasmic Ca2+ levels via the inositol 1,4,5-trisphosphate receptor (InsP3R) plays a critical role in this process. However, the m
Externí odkaz:
https://doaj.org/article/13ced7af04d2487e94921a4bcf5c1df8
Autor:
Long Yang, Wenwen Gu, King-Ho Cheung, Lan Yan, Benjamin Chun-Kit Tong, Yuanying Jiang, Jun Yang
Publikováno v:
BMC Biology, Vol 18, Iss 1, Pp 1-2 (2020)
An amendment to this paper has been published and can be accessed via the original article.
Externí odkaz:
https://doaj.org/article/32d4c6ec33d04bc4bd35246e261988f5