Zobrazeno 1 - 10
of 968
pro vyhledávání: '"King Tan"'
Autor:
Sinan Xiong, Jianbiao Zhou, Tze King Tan, Tae-Hoon Chung, Tuan Zea Tan, Sabrina Hui-Min Toh, Nicole Xin Ning Tang, Yunlu Jia, Yi Xiang See, Melissa Jane Fullwood, Takaomi Sanda, Wee-Joo Chng
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Multiple myeloma is a hematological malignancy arising from immunoglobulin-secreting plasma cells. It remains poorly understood how chromatin rewiring of regulatory elements contributes to tumorigenesis and therapy resistance in myeloma. Her
Externí odkaz:
https://doaj.org/article/a72d588788c3426aa48efeac9ff0d625
Autor:
Robert Kridel, Fong Chun Chan, Anja Mottok, Merrill Boyle, Pedro Farinha, King Tan, Barbara Meissner, Ali Bashashati, Andrew McPherson, Andrew Roth, Karey Shumansky, Damian Yap, Susana Ben-Neriah, Jamie Rosner, Maia A Smith, Cydney Nielsen, Eva Giné, Adele Telenius, Daisuke Ennishi, Andrew Mungall, Richard Moore, Ryan D Morin, Nathalie A Johnson, Laurie H Sehn, Thomas Tousseyn, Ahmet Dogan, Joseph M Connors, David W Scott, Christian Steidl, Marco A Marra, Randy D Gascoyne, Sohrab P Shah
Publikováno v:
PLoS Medicine, Vol 13, Iss 12, p e1002197 (2016)
BackgroundFollicular lymphoma (FL) is an indolent, yet incurable B cell malignancy. A subset of patients experience an increased mortality rate driven by two distinct clinical end points: histological transformation and early progression after immuno
Externí odkaz:
https://doaj.org/article/cfa88ca4dd45448eacb1f85e9a67401d
Autor:
Gabriel Chew, Aaron Shengting Mai, John F. Ouyang, Yueyue Qi, Yinxia Chao, Qing Wang, Enrico Petretto, Eng-King Tan
Publikováno v:
npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-11 (2024)
Abstract Blood-based gene expression signatures could potentially be used as biomarkers for PD. However, it is unclear whether genetically-regulated transcriptomic signatures can provide novel gene candidates for use as PD biomarkers. We leveraged on
Externí odkaz:
https://doaj.org/article/9ff9d1d7fa4f4d8294c483c3b3fdaab4
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-10 (2024)
Abstract Passive immunotherapy with specific antibodies targeting Amyloid β (Aβ) peptide or tubulin-associated unit (tau) protein has emerged as a promising therapeutic approach in Alzheimer’s disease (AD). However, in a recent phase III clinical
Externí odkaz:
https://doaj.org/article/20bd9b6e59364637ba67ec11e9fc2554
Autor:
BaoLing Chen, Hang Zhou, XinZi Liu, Wanlin Yang, Yuqi Luo, Shuzhen Zhu, Jialing Zheng, Xiaobo Wei, Ling-Ling Chan, Eng-King Tan, Qing Wang
Publikováno v:
Neurobiology of Disease, Vol 201, Iss , Pp 106693- (2024)
Introduction: Peripheral cytokine levels may affect specific brain volumes. Few studies have examined this possible relationship. Objective: In a case–control study, we used magnetic resonance imaging (MRI) voxel-based morphological analysis techni
Externí odkaz:
https://doaj.org/article/4ebdc4d642834728aaaf3761f228d57d
Autor:
Thomas Welton, Septian Hartono, Weiling Lee, Peik Yen Teh, Wenlu Hou, Robert Chun Chen, Celeste Chen, Ee Wei Lim, Kumar M. Prakash, Louis C. S. Tan, Eng King Tan, Ling Ling Chan
Publikováno v:
Frontiers in Aging Neuroscience, Vol 16 (2024)
PurposeSusceptibility map weighted imaging (SMWI), based on quantitative susceptibility mapping (QSM), allows accurate nigrosome-1 (N1) evaluation and has been used to develop Parkinson’s disease (PD) deep learning (DL) classification algorithms. N
Externí odkaz:
https://doaj.org/article/846105a89b9f4c0d896133f5b74c9a35
Autor:
Ziguang Wang, Shuai Li, Sheng Zhang, Tianyu Zhang, Yujie Wu, Anqi Liu, Kui Wang, Xiaowen Ji, Haiqun Cao, Yinglao Zhang, Eng King Tan, Yongcheng Wang, Yirong Wang, Wei Liu
Publikováno v:
eLife, Vol 13 (2024)
Host-microbe interactions are virtually bidirectional, but how the host affects their microbiome is poorly understood. Here, we report that the host is a critical modulator to regulate the lifestyle switch and pathogenicity heterogeneity of the oppor
Externí odkaz:
https://doaj.org/article/bf8a5df4bc82416c8927c63ddcdc9691
Autor:
Teddy J. W. Tng, Barbara Wing Yan Wong, Esther H. Y. Sim, Eng King Tan, Wilson W. B. Goh, Kah-Leong Lim
Publikováno v:
Translational Medicine Communications, Vol 9, Iss 1, Pp 1-21 (2024)
Abstract Parkinson’s disease (PD) is a prevalent neurodegenerative disorder affecting millions of elderly individuals worldwide. Clinically, PD is diagnosed based on the presentation of motoric symptoms. Other methods such as F-DOPA PET scan or α-
Externí odkaz:
https://doaj.org/article/1f023a8c5dfc4c8085e7636fbddf049a
Autor:
Murni Tio, Rujing Wen, Cai Ning Choo, Jian Bin Tan, Aaron Chua, Bin Xiao, Jeyapriya Rajameenakshi Sundaram, Christine Hui Shan Chan, Eng-King Tan
Publikováno v:
Journal of Biomedical Science, Vol 31, Iss 1, Pp 1-23 (2024)
Abstract Background Mutations in CHCHD2 have been linked to Parkinson’s disease, however, their exact pathophysiologic roles are unclear. The p32 protein has been suggested to interact with CHCHD2, however, the physiological functions of such inter
Externí odkaz:
https://doaj.org/article/6b0c5e5c904f4378a64375f261a25084
Publikováno v:
Frontiers in Psychiatry, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/63f5d879fe864ad890f1d1cebcd49e0e