Zobrazeno 1 - 10
of 22
pro vyhledávání: '"King L. Hung"'
Autor:
Adriana Gonzalez-Sandoval, Katja Pekrun, Shinnosuke Tsuji, Feijie Zhang, King L. Hung, Howard Y. Chang, Mark A. Kay
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract Recombinant adeno-associated viral vectors (rAAVs) are among the most commonly used vehicles for in vivo based gene therapies. However, it is hard to predict which AAV capsid will provide the most robust expression in human subjects due to t
Externí odkaz:
https://doaj.org/article/d62aaf6b8f6e41b794d5bf3b8b68ef81
Autor:
Rene Yu-Hong Cheng, King L. Hung, Tingting Zhang, Claire M. Stoffers, Andee R. Ott, Emmaline R. Suchland, Nathan D. Camp, Iram F. Khan, Swati Singh, Ying-Jen Yang, David J. Rawlings, Richard G. James
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Plasma B cells (PC) are a potential source for protein replacement as they could be engineered to secrete protein other than antibody. Here the authors engineer B cells to express exogenous proteins and demonstrate that these cells can persist long t
Externí odkaz:
https://doaj.org/article/a7a059db17ba4c239eb066542f930a81
Autor:
King L. Hung, Jens Luebeck, Siavash R. Dehkordi, Caterina I. Colón, Rui Li, Ivy Tsz-Lo Wong, Ceyda Coruh, Prashanthi Dharanipragada, Shirley H. Lomeli, Natasha E. Weiser, Gatien Moriceau, Xiao Zhang, Chris Bailey, Kathleen E. Houlahan, Wenting Yang, Rocío Chamorro González, Charles Swanton, Christina Curtis, Mariam Jamal-Hanjani, Anton G. Henssen, Julie A. Law, William J. Greenleaf, Roger S. Lo, Paul S. Mischel, Vineet Bafna, Howard Y. Chang
Publikováno v:
Nature genetics, vol 54, iss 11
Extrachromosomal DNA (ecDNA) is a common mode of oncogene amplification but is challenging to analyze. Here, we adapt CRISPR-CATCH, in vitro CRISPR-Cas9 treatment and pulsed field gel electrophoresis of agarose-entrapped genomic DNA, previously devel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe1d24056e03472a95c8b1515921aefc
https://doi.org/10.1038/s41588-022-01190-0
https://doi.org/10.1038/s41588-022-01190-0
Autor:
Rocío Chamorro González, Thomas Conrad, Maja C. Stöber, Robin Xu, Mădălina Giurgiu, Elias Rodriguez-Fos, Katharina Kasack, Lotte Brückner, Eric van Leen, Konstantin Helmsauer, Heathcliff Dorado Garcia, Maria E. Stefanova, King L. Hung, Yi Bei, Karin Schmelz, Marco Lodrini, Stefan Mundlos, Howard Y. Chang, Hedwig E. Deubzer, Sascha Sauer, Angelika Eggert, Johannes H. Schulte, Roland F. Schwarz, Kerstin Haase, Richard P. Koche, Anton G. Henssen
Extrachromosomal DNAs (ecDNAs) are common in cancer, but many questions about their origin, structural dynamics and impact on intratumor heterogeneity are still unresolved. Here we describe single-cell extrachromosomal circular DNA and transcriptome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc99ed2c6257eafccfbc8313ccf81a41
http://edoc.mdc-berlin.de/23342/2/23342suppl.zip
http://edoc.mdc-berlin.de/23342/2/23342suppl.zip
Autor:
Monte M. Winslow, Charles Swanton, Dmitri A. Petrov, Christopher D. McFarland, Le Cong, Christian A. Kunder, Wen-Yang Lin, Maryam Yousefi, Shi Ya C. Lee, Leo C. Chen, King L. Hung, Rui Tang, Emily L. Ashkin, Emily G. Shuldiner, Nicholas W. Hughes, Christopher W. Murray, Laura Andrejka, Min K. Tsai, Chuan Li, Su Kit Chew, Hongchen Cai
(Updated, with minor text changes and rearrangements.) Figure S1-S4 (related to Figure 1) provide details on the selected genes and method. Figure S5 (related to Figure 2) shows the percentiles of all sgRNAs. Figure S6-S8 (related to Figure 3) presen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb999fe9b53b0a94ffbad60dec52b16e
https://doi.org/10.1158/2159-8290.22540429
https://doi.org/10.1158/2159-8290.22540429
Autor:
Monte M. Winslow, Charles Swanton, Dmitri A. Petrov, Christopher D. McFarland, Le Cong, Christian A. Kunder, Wen-Yang Lin, Maryam Yousefi, Shi Ya C. Lee, Leo C. Chen, King L. Hung, Rui Tang, Emily L. Ashkin, Emily G. Shuldiner, Nicholas W. Hughes, Christopher W. Murray, Laura Andrejka, Min K. Tsai, Chuan Li, Su Kit Chew, Hongchen Cai
Cancer genotyping has identified a large number of putative tumor suppressor genes. Carcinogenesis is a multistep process, but the importance and specific roles of many of these genes during tumor initiation, growth, and progression remain unknown. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1b404e969247084e511f71eff4ac10a
https://doi.org/10.1158/2159-8290.c.6549376
https://doi.org/10.1158/2159-8290.c.6549376
Autor:
Monte M. Winslow, Charles Swanton, Dmitri A. Petrov, Christopher D. McFarland, Le Cong, Christian A. Kunder, Wen-Yang Lin, Maryam Yousefi, Shi Ya C. Lee, Leo C. Chen, King L. Hung, Rui Tang, Emily L. Ashkin, Emily G. Shuldiner, Nicholas W. Hughes, Christopher W. Murray, Laura Andrejka, Min K. Tsai, Chuan Li, Su Kit Chew, Hongchen Cai
Table S2. The information of sgRNA vectors in the high content Lenti-sgTS102/Cre pool.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bd3cce0b27516cffd3dcfa9479b7b40
https://doi.org/10.1158/2159-8290.22540423
https://doi.org/10.1158/2159-8290.22540423
Publikováno v:
Cancer Discov
Summary: Extrachromosomal DNA circles (ecDNA) are a common mechanism for oncogene amplification and are associated with worse clinical outcomes compared with other types of oncogene amplification. Several recent discoveries of ecDNA hubs—local cong
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f78885da86f24f5a9d03e9bc4e2b37e6
https://doi.org/10.1158/2159-8290.cd-22-0076
https://doi.org/10.1158/2159-8290.cd-22-0076
Autor:
Adriana Gonzalez-Sandoval, Shinnosuke Tsuji, Feijie Zhang, King L. Hung, Howard Y. Chang, Katja Pekrun, Mark A. Kay
SummaryRecombinant adeno-associated viral vectors (rAAVs) are among the most commonly used vehicles for in vivo based gene therapies. However, it is hard to predict which AAV capsid will provide the most robust expression in human subjects due to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2afc5f19319580a17325b00e92022021
https://doi.org/10.1101/2022.10.06.511169
https://doi.org/10.1101/2022.10.06.511169
Publikováno v:
Nat Struct Mol Biol
Oncogene amplification on extrachromosomal DNA (ecDNA) is prevalent in human cancer and is associated with poor outcomes. Clonal, megabase-sized circular ecDNAs in cancer are distinct from nonclonal, small sub-kilobase-sized DNAs that may arise durin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c821aae1fb9971840d9c9dfd0686b0dc
https://pubmed.ncbi.nlm.nih.gov/35948767
https://pubmed.ncbi.nlm.nih.gov/35948767