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Repurposing cetylpyridinium chloride and domiphen bromide as phosphoethanolamine transferase inhibitor to combat colistin-resistant Enterobacterales.

Autor: Xu C; Department of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang 212013, China; State Key Laboratory of Chemical Biology and Drug Discovery, Department of Food Science and Nutrition, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China; State Key Laboratory of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China., Cheng Q; State Key Laboratory of Chemical Biology and Drug Discovery, Department of Food Science and Nutrition, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China; State Key Laboratory of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China., Chen K; State Key Laboratory of Chemical Biology and Drug Discovery, Department of Food Science and Nutrition, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China., Kin So P; State Key Laboratory of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China., Jin W; State Key Laboratory of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China., Gu Y; State Key Laboratory of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China., Wong IL; State Key Laboratory of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China., Chan EWC; State Key Laboratory of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China., Wong KY; State Key Laboratory of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China., Chan KF; State Key Laboratory of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China. Electronic address: kf.chan@polyu.edu.hk., Chen S; State Key Laboratory of Chemical Biology and Drug Discovery, Department of Food Science and Nutrition, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China. Electronic address: sheng.chen@polyu.edu.hk.

Publikováno v: Microbiological research [Microbiol Res] 2024 Nov; Vol. 288, pp. 127879. Date of Electronic Publication: 2024 Aug 15.

Alveolar macrophage function is impaired following inhalation of berry e-cigarette vapor.

Autor: Kulle A; Department of Microbiology and Immunology, McGill University, Montréal, QC H3A 2B4, Canada., Li Z; Department of Pharmacology and Therapeutics, McGill University, Montréal, QC H3G 1Y6, Canada., Kwak A; Department of Microbiology and Immunology, McGill University, Montréal, QC H3A 2B4, Canada., Mancini M; Department of Microbiology and Immunology, McGill University, Montréal, QC H3A 2B4, Canada.; Dahdaleh Institute for Genomic Medicine, Montréal, QC H3A 0G1, Canada., Young D; Department of Physiology and Pharmacology, University of Calgary, Calgary, AB T2N 4N1, Canada., Avizonis DZ; Goodman Cancer Institute, McGill University, Montréal, QC H3A 1A3, Canada., Groleau M; Department of Microbiology and Immunology, McGill University, Montréal, QC H3A 2B4, Canada., Baglole CJ; Department of Pharmacology and Therapeutics, McGill University, Montréal, QC H3G 1Y6, Canada.; Meakins-Christie Laboratories, Research Institute of the McGill University Health Centre, Montréal, QC H4A 3J1, Canada., Behr MA; Department of Microbiology and Immunology, McGill University, Montréal, QC H3A 2B4, Canada., King IL; Department of Microbiology and Immunology, McGill University, Montréal, QC H3A 2B4, Canada.; Meakins-Christie Laboratories, Research Institute of the McGill University Health Centre, Montréal, QC H4A 3J1, Canada.; McGill Interdisciplinary Initiative in Infection and Immunity, Montréal, QC H3A 1Y2, Canada.; McGill Centre for Microbiome Research, Montréal, QC H4A 3J1, Canada., Divangahi M; Department of Microbiology and Immunology, McGill University, Montréal, QC H3A 2B4, Canada.; Meakins-Christie Laboratories, Research Institute of the McGill University Health Centre, Montréal, QC H4A 3J1, Canada., Langlais D; Department of Microbiology and Immunology, McGill University, Montréal, QC H3A 2B4, Canada.; Dahdaleh Institute for Genomic Medicine, Montréal, QC H3A 0G1, Canada.; Department of Human Genetics, McGill University, Montréal, QC H3A 0C7, Canada., Wang J; Department of Immunology and Microbiology, Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai 20025, China., Blagih J; Department of Obstetrics and Gynecology, University of Montréal, Montréal, QC H3C 3J7, Canada., Penz E; Department of Medicine, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada., Dufour A; Department of Physiology and Pharmacology, University of Calgary, Calgary, AB T2N 4N1, Canada., Thanabalasuriar A; Department of Microbiology and Immunology, McGill University, Montréal, QC H3A 2B4, Canada.; Department of Pharmacology and Therapeutics, McGill University, Montréal, QC H3G 1Y6, Canada.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Oct; Vol. 121 (40), pp. e2406294121. Date of Electronic Publication: 2024 Sep 23.

Genome-wide association studies with experimental validation identify a protective role for B lymphocytes against chronic post-surgical pain.

Autor: Parisien M; Faculty of Dental Medicine and Oral Health Sciences, Department of Anesthesia, Faculty of Medicine, Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC, Canada., van Reij RRI; Department of Anesthesiology and Pain Management, Maastricht University Medical Center+, School for Mental Health and Neuroscience (MHeNs), Faculty of Health, Medicine and Life Sciences, University of Maastricht, Maastricht, The Netherlands., Khoury S; Faculty of Dental Medicine and Oral Health Sciences, Department of Anesthesia, Faculty of Medicine, Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC, Canada., Koseli E; Department of Pharmacology and Toxicology and Translational Research Initiative for Pain and Neuropathy, Virginia Commonwealth University, Richmond, VA, USA., Karaky M; Faculty of Dental Medicine and Oral Health Sciences, Department of Anesthesia, Faculty of Medicine, Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC, Canada., Silva JR; Department of Anesthesiology, Faculty of Health Sciences, Queen's University, Kingston, ON, Canada; Department of Biomedical & Molecular Sciences, Faculty of Health Sciences, Queen's University, Kingston, ON, Canada; Centre for Neuroscience Studies, Queen's University, Kingston, ON, Canada., Taheri G; Department of Biomedical & Molecular Sciences, Faculty of Health Sciences, Queen's University, Kingston, ON, Canada; Centre for Neuroscience Studies, Queen's University, Kingston, ON, Canada., van den Hoogen NJ; Department of Anesthesiology and Pain Management, Maastricht University Medical Center+, School for Mental Health and Neuroscience (MHeNs), Faculty of Health, Medicine and Life Sciences, University of Maastricht, Maastricht, The Netherlands., Peng G; Department of Microbiology and Immunology, Meakins-Christie Laboratories, Research Institute of the McGill University Health Centre, Montreal, QC, Canada., Allegri M; Department of Pain Therapy, Ensemble Hospitalier de la Côte, Morges, Switzerland., De Gregori M; Pain Therapy Service, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy., Chelly JE; Department of Anesthesiology and Perioperative Medicine, University of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA, USA., Rakel BA; College of Nursing, University of Iowa, Iowa City, IA, USA., Aasvang EK; Department of Anesthesiology, Centre for Cancer and Organ Diseases, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark., Kehlet H; Section of Surgical Pathophysiology 7621, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark., Buhre WFFA; Department of Anesthesiology, Division of Anesthesiology, Emergency and Intensive Care Medicine, University Medical Center Utrecht, Utrecht, The Netherlands., Bryant CD; Center for Drug Discovery, Department of Pharmaceutical Sciences, Northeastern University, Boston, MA, USA., Damaj MI; Department of Pharmacology and Toxicology and Translational Research Initiative for Pain and Neuropathy, Virginia Commonwealth University, Richmond, VA, USA., King IL; Department of Microbiology and Immunology, Meakins-Christie Laboratories, Research Institute of the McGill University Health Centre, Montreal, QC, Canada; McGill Interdisciplinary Initiative in Infection and Immunity, McGill Centre for Microbiome Research, Montreal, QC, Canada., Ghasemlou N; Department of Anesthesiology, Faculty of Health Sciences, Queen's University, Kingston, ON, Canada; Department of Biomedical & Molecular Sciences, Faculty of Health Sciences, Queen's University, Kingston, ON, Canada; Centre for Neuroscience Studies, Queen's University, Kingston, ON, Canada., Mogil JS; Department of Psychology, Faculty of Science, Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC, Canada., Joosten EAJ; Department of Anesthesiology and Pain Management, Maastricht University Medical Center+, School for Mental Health and Neuroscience (MHeNs), Faculty of Health, Medicine and Life Sciences, University of Maastricht, Maastricht, The Netherlands., Diatchenko L; Faculty of Dental Medicine and Oral Health Sciences, Department of Anesthesia, Faculty of Medicine, Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC, Canada. Electronic address: luda.diatchenko@mcgill.ca.

Publikováno v: British journal of anaesthesia [Br J Anaesth] 2024 Aug; Vol. 133 (2), pp. 360-370. Date of Electronic Publication: 2024 Jun 10.

Worming into infancy: Exploring helminth-microbiome interactions in early life.

Autor: Bogza A; Department of Microbiology & Immunology, McGill University, Montreal, QC, Canada; McGill Centre for Microbiome Research, McGill University, Montreal, QC, Canada; Meakins-Christie Laboratories, Research Institute of the McGill University Health Centre, Montreal, QC, Canada; McGill University Research Centre on Complex Traits, Montreal, QC, Canada., King IL; Department of Microbiology & Immunology, McGill University, Montreal, QC, Canada; McGill Centre for Microbiome Research, McGill University, Montreal, QC, Canada; Meakins-Christie Laboratories, Research Institute of the McGill University Health Centre, Montreal, QC, Canada. Electronic address: irah.king@mcgill.ca., Maurice CF; Department of Microbiology & Immunology, McGill University, Montreal, QC, Canada; McGill Centre for Microbiome Research, McGill University, Montreal, QC, Canada; McGill University Research Centre on Complex Traits, Montreal, QC, Canada. Electronic address: corinne.maurice@mcgill.ca.

Publikováno v: Cell host & microbe [Cell Host Microbe] 2024 May 08; Vol. 32 (5), pp. 639-650.