Regulation of GLI1 by cis DNA elements and epigenetic marks

Autor: David J. Robbins, Robert L. Taylor, Kathrine B. Sylvestersen, Stephen Iannaccone, Ronnie Childs, King Fu Leong, Joon Won Yoon, David O. Walterhouse, Jun Long, Philip M. Iannaccone, Michael L. Nielsen

Publikováno v: Taylor, R, Long, J, Yoon, J W, Childs, R, Sylvestersen, K B, Nielsen, M L, Leong, K-F, Iannaccone, S, Walterhouse, D O, Robbins, D J & Iannaccone, P 2019, ' Regulation of GLI1 by cis DNA elements and epigenetic marks ', DNA Repair, vol. 79, pp. 10-21 . https://doi.org/10.1016/j.dnarep.2019.04.011
DNA repair

GLI1 is one of three transcription factors (GLI1, GLI2 and GLI3) that mediate the Hedgehog signal transduction pathway and play important roles in normal development. GLI1 and GLI2 form a positive-feedback loop and function as human oncogenes. The mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5f513f01ed19892e9a068d8432c2d4d
https://doi.org/10.1016/j.dnarep.2019.04.011

Suppressor of cytokine signaling 1 interacts with oncogenic lymphocyte-specific protein tyrosine kinase

Autor: Srividya Venkitachalam, Fu-Yu Chueh, King-Fu Leong, Chao-Lan Yu, Samantha Pabich

Publikováno v: Oncology Reports. 25

Lymphocyte-specific protein tyrosine kinase (Lck) plays a key role in T cell signal transduction and is tightly regulated by phosphorylation and dephosphorylation. Lck can function as an oncoprotein when overexpressed or constantly activated by mutat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcbd112b4f5bd0369b01cb5abf02acb6
https://doi.org/10.3892/or.2011.1144

Abstract 3245: Targeted inhibition of Hedgehog (HH) signal transduction in rhabdomyosarcoma (RMS) reduces cell survival in vitro and tumor growth in vivo

Autor: Stephen Iannaccone, David O. Walterhouse, Gregory U. Taborn, Philip M. Iannaccone, Marilyn L. G. Lamm, Christopher M. Chandler, King-Fu Leong, Joon Won Yoon

Publikováno v: Cancer Research. 75:3245-3245

RMS is the most common sarcoma of childhood. Approximately 60% of embryonal RMS (ERMS) and more rarely alveolar RMS (ARMS) express HH pathway components. However, roles for the HH signal transduction pathway in RMS biology and as a therapeutic target

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::95ac819d69c20d04c37383c78d2e3f73
https://doi.org/10.1158/1538-7445.am2015-3245

Abstract 4259: Active hedgehog (HH) signal transduction in rhabdomyosarcoma (RMS)

Autor: David O. Walterhouse, Stephen Iannaccone, Philip M. Iannaccone, Joon Won Yoon, Marilyn Lamm, King-Fu Leong

Publikováno v: Cancer Research. 73:4259-4259

RMS is the most common sarcoma of childhood. The majority of embryonal RMS (ERMS) and a minority of alveolar RMS (ARMS) express HH pathway components. However, a role for the HH signal transduction pathway is incompletely defined in RMS. Co-regulatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e1c3fffb4ad2609bf430cdcd7bd4ae8b
https://doi.org/10.1158/1538-7445.am2013-4259

Abstract LB-24: Nuclear localization of PDC-E2, a mitochondrial enzyme, and its role in STAT5-dependent gene transcription

Autor: Fu-Shin Chueh, Fu-Yu Chueh, King-Fu Leong, Samantha Pabich, Chao-Lan Yu, Srividya Venkitachalam

Publikováno v: Cancer Research. 70:LB-24

STAT (signal transducer and activator of transcription) proteins play a critical role in cellular response to a wide variety of cytokine and growth factors by regulating specific nuclear genes. Many STAT-target genes are involved in cell proliferatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4c18e658794c76cb02b2fdb441196409
https://doi.org/10.1158/1538-7445.am10-lb-24