Zobrazeno 1 - 10
of 109
pro vyhledávání: '"King C Chan"'
Autor:
Cheng-Hsin Wei, Lu Huang, Blair Kreh, Xiuxia Liu, Liliya Tyutyunyk-Massey, Masanori Kawakami, Zibo Chen, Mi Shi, Serguei Kozlov, King C. Chan, Thorkell Andresson, Mary Carrington, Vidyasagar Vuligonda, Martin E. Sanders, Amir Horowitz, Patrick Hwu, Weiyi Peng, Ethan Dmitrovsky, Xi Liu
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract All-trans-retinoic acid (ATRA), the retinoic acid receptors (RARs) agonist, regulates cell growth, differentiation, immunity, and survival. We report that ATRA-treatment repressed cancer growth in syngeneic immunocompetent, but not immunodef
Externí odkaz:
https://doaj.org/article/3a6d32daebaf4a6c91b60abe62aa93bd
Autor:
Xiuxiu Lu, Venkata R. Sabbasani, Vasty Osei-Amponsa, Christine N. Evans, Julianna C. King, Sergey G. Tarasov, Marzena Dyba, Sudipto Das, King C. Chan, Charles D. Schwieters, Sulbha Choudhari, Caroline Fromont, Yongmei Zhao, Bao Tran, Xiang Chen, Hiroshi Matsuo, Thorkell Andresson, Raj Chari, Rolf E. Swenson, Nadya I. Tarasova, Kylie J. Walters
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Rpn13 is a substrate receptor of the 26S proteasome and an anti-cancer drug target. Here, the authors identify and characterize XL5, a lead compound that binds to the N-terminal Pru domain of human Rpn13 (hRpn13), solve the NMR structure of XL5-ligat
Externí odkaz:
https://doaj.org/article/08204c7dee354ca7ab5e0c3b7e0c28d6
Autor:
Charles D. Schwieters, Xiuxiu Lu, Vasty Osei-Amponsa, Julianna C. King, Thorkell Andresson, Caroline Fromont, Rolf E. Swenson, Bao Tran, Xiang Chen, Kylie J. Walters, Yongmei Zhao, Nadya I. Tarasova, Hiroshi Matsuo, Marzena A. Dyba, Sulbha Choudhari, Raj Chari, Venkata R. Sabbasani, Sergey G. Tarasov, Christine N. Evans, King C. Chan
Proteasome substrate receptor hRpn13 is a promising anti-cancer target. By integrated in silico and biophysical screening, we identified a chemical scaffold that binds hRpn13 with non-covalent interactions that mimic the proteasome and a weak electro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb1579d6d5f0d3b01c43733af2d66184
https://doi.org/10.1101/2021.07.16.452547
https://doi.org/10.1101/2021.07.16.452547
Autor:
Eric E. Simanek, Josip Blonder, King C. Chan, Ankit Shah, Marina A. Dobrovolskaia, Anna Ilinskaya, Alan E. Enciso, Jan A. Kaczmarczyk
Publikováno v:
Nanomedicine: Nanotechnology, Biology and Medicine. 17:266-275
The complement system plays an essential role in both innate and adaptive immunity. The traditional understanding of this system comes from studies investigating complement proteins produced by the liver and present in plasma to “complement” the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86b6f03053f9c703aa3345295cee7f1d
https://doi.org/10.1016/j.nano.2019.02.002
https://doi.org/10.1016/j.nano.2019.02.002
Autor:
Maxwell P. Lee, King C. Chan, Navdeep Malik, Hualong Yan, Yunlong He, Yu-Chou Tseng, Huaitian Liu, Jing Huang, Mangmang Li, Waseem Alzamzami, Joe T Nguyen, Beverly A. Mock, Wendy Dubois, Tyler J Peat, Thorkell Andresson, Lino Tessarollo, Gamze Ayaz, Young-Im Kim
Publikováno v:
EMBO Rep
Metabolic regulation is critical for the maintenance of pluripotency and the survival of embryonic stem cells (ESCs). The transcription factor Tfcp2l1 has emerged as a key factor for the naive pluripotency of ESCs. Here, we report an unexpected role
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfc4511d612e3b320237d05747599494
https://europepmc.org/articles/PMC8183408/
https://europepmc.org/articles/PMC8183408/
Autor:
Rhonda R. Roberts, Brian T. Luke, Carly M Van Wagoner, Jan Kaczmarczyk, Colantonio Simona, Robin A. Felder, Richard G. Saul, King C Chan, Josip Blonder
Publikováno v:
Oncotarget
Background: Lung cancer is the leading cause of cancer-related deaths in the USA and worldwide. Yet, about 95% of new drug candidates validated in preclinical phase eventually fail in clinical trials. Such a high attrition rate is attributed mostly t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1006c8eb7d3140ea7925addca94b3fac
https://doi.org/10.21203/rs.3.rs-72194/v1
https://doi.org/10.21203/rs.3.rs-72194/v1
Autor:
Heidi Varner, Lindsay L. Peterson, Kent Armeson, Michael B. Lilly, Marvella E. Ford, Mathew J. Gregoski, Kendrea D. Knight, Lourdes M. Nogueira, David P. Turner, Marian H. Taylor, Stefan Ambs, Rita Kramer, Tonya F. Turner, Van Phan, Bradley A. Krisanits, Laura Spruill, Jaime Uribarri, Gayenell S. Magwood, King C. Chan, Katherine R. Walter, Mark J. Clair, Shweta Singh, Andrea M. Abbott, Victoria J. Findlay, Elizabeth Garrett-Mayer, Amanda C. La Rue, Ebony J. Hilton
Publikováno v:
Breast Cancer Research and Treatment
Purpose Lifestyle factors associated with personal behavior can alter tumor-associated biological pathways and thereby increase cancer risk, growth, and disease recurrence. Advanced glycation end products (AGEs) are reactive metabolites produced endo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::198076e84d1f2e6af020befc0034553c
https://doi.org/10.1007/s10549-018-4992-7
https://doi.org/10.1007/s10549-018-4992-7
Autor:
Katherine R. Walter, David P. Turner, Laura Spruill, King C. Chan, Ebony J. Hilton, Amanda C. La Rue, Michael B. Lilly, Kendrea D. Knight, Elizabeth Garrett-Mayer, Mathew J. Gregoski, Shweta Singh, Rita Kramer, Lourdes M. Nogueira, Gayenell S. Magwood, Victoria J. Findlay, Tonya F. Turner, Jaime Uribarri, Bradley A. Krisanits, Mark J. Clair, Stefan Ambs, Kent Armeson, Marian H. Taylor, Lindsay L. Peterson, Heidi Varner, Ford E. Ford
Publikováno v:
Cancer Epidemiology, Biomarkers & Prevention. 29:C024-C024
Lifestyle factors associated with personal behavior can alter tumor-associated biologic pathways and thereby increase cancer risk, growth and disease recurrence. Advanced glycation end products (AGEs) are reactive metabolites produced endogenously as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f7ded5b2a07b8e21714927dc78429a0c
https://doi.org/10.1158/1538-7755.disp18-c024
https://doi.org/10.1158/1538-7755.disp18-c024
Autor:
Xu Zhang, Tapan K Maity, Abhilash Venugopalan, Daniel R. Crooks, Vikram Misra, Nitin Roper, Andrew N. Lane, Andresson Thorkell, King C. Chan, W. Marston Linehan, Udayan Guha, Khoa Dang Nguyen, Constance M. Cultraro, Yue Qi, Matthew Lynberg
Publikováno v:
The FASEB Journal. 34:1-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d2bef9c83be16f48f0940750cc3ae42
https://doi.org/10.1096/fasebj.2020.34.s1.00602
https://doi.org/10.1096/fasebj.2020.34.s1.00602
Autor:
Abisola Abisoye-Ogunniyan, Jesse M. Jaynes, Clayton Yates, Xia Xu, Zachary Knotts, Theresa Guerin, Jerome J. Schlomer, King C. Chan, Dandan Li, Jeffrey W. Cary, Serguei Kozlov, Maura O'Neill, Kanniah Rajasekaran, Udo Rudloff, Thorkell Andresson
Publikováno v:
J Pharm Biomed Anal
Synthetic host defense peptides (HDP) are a new class of promising therapeutic agents with potential application in a variety of diseases. RP-182 is a 10mer synthetic HDP design, which selectively reduces M2-like tumor associated macrophages via enga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::938fcbc4f86032c318722258362b7041
https://doi.org/10.1016/j.jpba.2020.113093
https://doi.org/10.1016/j.jpba.2020.113093