A humanized Caenorhabditis elegans model of hereditary spastic paraplegia-associated variants in KLC4

Autor: Selin Gümüşderelioğlu, Lauren Resch, Trisha Brock, Undiagnosed Diseases Network, G. W. Gant Luxton, Heidi Cope, Queenie K.-G. Tan, Christopher Hopkins, Daniel A. Starr

Publikováno v: Disease Models & Mechanisms, Vol 16, Iss 8 (2023)

Externí odkaz: https://doaj.org/article/be8772a0c6b144fab06a4befcf2a6fd9

Kinesin light chain-1 serine-460 phosphorylation is altered in Alzheimer’s disease and regulates axonal transport and processing of the amyloid precursor protein

Autor: Gábor M. Mórotz, Elizabeth B. Glennon, Jenny Greig, Dawn H. W. Lau, Nishita Bhembre, Francesca Mattedi, Nadine Muschalik, Wendy Noble, Alessio Vagnoni, Christopher C. J. Miller

Publikováno v: Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-13 (2019)

Abstract Damage to axonal transport is an early pathogenic event in Alzheimer’s disease. The amyloid precursor protein (APP) is a key axonal transport cargo since disruption to APP transport promotes amyloidogenic processing of APP. Moreover, alter

Externí odkaz: https://doaj.org/article/98c195ce202446dca910c86e79b79ccb

Defective Kinesin Heavy Chain Behavior in Mouse Kinesin Light Chain Mutants

Autor: Rahman, Amena, Kamal, Adeela, Roberts, Elizabeth A.

Publikováno v: The Journal of Cell Biology, 1999 Sep . 146(6), 1277-1287.

Externí odkaz: https://www.jstor.org/stable/1619513

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Kinesin light chain-1 serine-460 phosphorylation is altered in Alzheimer's disease and regulates axonal transport and processing of the amyloid precursor protein

Autor: Nadine Muschalik, Dawn H. W. Lau, Jenny Greig, Gábor M. Mórotz, Elizabeth B. Glennon, Francesca Mattedi, Alessio Vagnoni, Wendy Noble, Nishita Bhembre, Christopher C.J. Miller

Publikováno v: Mórotz, G M, Glennon, E B, Greig, J, Lau, D H W, Bhembre, N, Mattedi, F, Muschalik, N, Noble, W, Vagnoni, A & Miller, C C J 2019, ' Kinesin light chain-1 serine-460 phosphorylation is altered in Alzheimer's disease and regulates axonal transport and processing of the amyloid precursor protein ', Acta Neuropathologica Communications, vol. 7, no. 1, 200 . https://doi.org/10.1186/s40478-019-0857-5
Acta Neuropathologica Communications
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-13 (2019)

Damage to axonal transport is an early pathogenic event in Alzheimer’s disease. The amyloid precursor protein (APP) is a key axonal transport cargo since disruption to APP transport promotes amyloidogenic processing of APP. Moreover, altered APP pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28c59c7dcaad7bf991f2fddb1941fd4a
https://kclpure.kcl.ac.uk/ws/files/148224846/Kinesin_light_chain_1_serine_460_VAGNONI_Publishedonline5December2019_GOLD_VoR_CC_BY_.pdf