Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Kinase suppressor of Ras"'
Autor:
Vladimir Girik, Larissa van Ek, Isabelle Dentand Quadri, Maral Azam, María Cruz Cobo, Marion Mandavit, Isabelle Riezman, Howard Riezman, Anne-Claude Gavin, Paula Nunes-Hasler
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 5, p 2996 (2024)
Ceramides regulate phagocytosis; however, their exact function remains poorly understood. Here, we sought (1) to develop genetically encoded fluorescent tools for imaging ceramides, and (2) to use them to examine ceramide dynamics during phagocytosis
Externí odkaz:
https://doaj.org/article/1ec9866cbcd74d599126b507202cf623
Akademický článek
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Autor:
Humair S. Quadri, Taylor J. Aiken, Michael Allgaeuer, Radim Moravec, Sean Altekruse, S. Perwez Hussain, Markku M. Miettinen, Stephen M. Hewitt, Udo Rudloff
Publikováno v:
BMC Cancer, Vol 17, Iss 1, Pp 1-12 (2017)
Abstract Background Despite the near universal occurrence of activating codon 12 KRAS somatic variants in pancreatic cancer, there is considerable heterogeneity in the molecular make-up, MAPK/ERK pathway activation states, and clinical outcome in thi
Externí odkaz:
https://doaj.org/article/527d1c81c4c049e59ebf15cc5b16be79
Autor:
Ying Yan, Chitra Palanivel, Charles A. Enke, Geoffrey A. Talmon, Nichole D. Brandquist, Keith R. Johnson, Lepakshe S. V. Madduri, Michael J. Baine, Sumin Zhou, Michel M. Ouellette
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 12, Pp 1192-1203 (2021)
Neoplasia (New York, N.Y.)
Neoplasia (New York, N.Y.)
We have previously reported an important role of PR55α, a regulatory subunit of PP2A Ser/Thr phosphatase, in the support of critical oncogenic pathways required for oncogenesis and the malignant phenotype of pancreatic cancer. The studies in this re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f832db5958c0092cf4988a30bef03318
http://www.sciencedirect.com/science/article/pii/S1476558621000877
http://www.sciencedirect.com/science/article/pii/S1476558621000877
Publikováno v:
Taiwanese Journal of Obstetrics & Gynecology, Vol 45, Iss 2, Pp 107-113 (2006)
The protein product of nm23-H1 gene has activity of nucleoside diphosphate (NDP) kinase, which catalyzes the phosphorylation of nucleoside diphosphates to the corresponding nucleoside triphosphates. Reductions in nm23 expression have been significant
Externí odkaz:
https://doaj.org/article/1cd66dd672c84a9bac05bfc3b01e2c02
Autor:
Peter D. Mace, James M. Murphy
Publikováno v:
The Journal of Biological Chemistry
Protein kinases are present in all domains of life and play diverse roles in cellular signaling. Whereas the impact of substrate phosphorylation by protein kinases has long been appreciated, it is becoming increasingly clear that protein kinases also
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::347bb969af6393a9dbd36972faefed95
https://doi.org/10.1016/j.jbc.2021.100705
https://doi.org/10.1016/j.jbc.2021.100705
Publikováno v:
FEBS Open Bio, Vol 4, Iss C, Pp 420-425 (2014)
FEBS Open Bio
FEBS Open Bio
Highlights • A truncated kinase suppressor of Ras 2 (T-KSR2) mRNA was identified. • T-KSR2 is expressed exclusively in mouse testes and sperm. • Analysis of T-KSR2 may enhance understanding of spermatogenesis and fertility.
The kinase supp
The kinase supp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4b6ced0b95425d61d2246924e590891
https://doi.org/10.1016/j.fob.2014.04.004
https://doi.org/10.1016/j.fob.2014.04.004
Autor:
Sivanandy Palanisamy, Dhananjayan Karthik, Kalathil Khairunnisa, Varsha Venugopal, Pulak Majumder
Publikováno v:
Bioinformation
Kinase Suppressor of Ras (KSR) is a molecular scaffold that interacts with the core kinase components of the ERK cascade, Raf, MEK, ERK to provide spatial and temporal regulation of Ras-dependent ERK cascade signaling. Interruption of this mechanism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b327bf04209bf64070c9dc3bfd95c015
https://doi.org/10.6026/97320630010580
https://doi.org/10.6026/97320630010580
RAF family kinases are central components of the Ras-RAF-MEK-ERK cascade. Dimerization is a key mechanism of RAF activation in response to physiological, pathological and pharmacological signals. It is mediated by a dimer interface region in the RAF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5124341cc5f590ff79ba9e91770abca
Autor:
Krisztina Takács-Vellai
Publikováno v:
Journal of Molecular Signaling; Vol 9 (2014); Art. 4
Journal of Molecular Signaling
Journal of Molecular Signaling
NM23-H1 (also known as NME1) was the first identified metastasis suppressor, which displays a nucleoside diphosphate kinase (NDPK) and histidine protein kinase activity. NDPKs are linked to many processes, such as cell migration, proliferation, diffe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6459925c4edc87b0e214c4e0f53fef1b
http://www.jmolecularsignaling.com/jms/article/view/1750-2187-9-4
http://www.jmolecularsignaling.com/jms/article/view/1750-2187-9-4